Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

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Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

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What functions are associated with Sphingosine 1-phosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Authors Title Published Journal PubMed Link
Japtok L et al. Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2. 2015 FASEB J. pmid:25911610
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Kang H et al. The Therapeutic Effects of Human Mesenchymal Stem Cells Primed with Sphingosine-1 Phosphate on Pulmonary Artery Hypertension. 2015 Stem Cells Dev. pmid:25761906
Oskeritzian CA et al. The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses. 2015 J. Allergy Clin. Immunol. pmid:25512083
Kurano M et al. LDL receptor and ApoE are involved in the clearance of ApoM-associated sphingosine 1-phosphate. 2015 J. Biol. Chem. pmid:25505264
Pan HY et al. Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis. 2015 Int Endod J pmid:24931601
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Kim ES et al. A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells. 2015 Chem. Biol. Interact. pmid:25980589
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Snider AJ et al. Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease. 2014 PLoS ONE pmid:25460165
Nakanaga K et al. Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo. 2014 J. Biochem. pmid:24451492
Langeslag M et al. Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons. 2014 Mol Pain pmid:25431213
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Guo S et al. Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen. 2014 Biochim. Biophys. Acta pmid:24603322
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Hamidi S et al. TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts. 2014 Biochim. Biophys. Acta pmid:24440818
Xu H et al. Sphingosine-1-phosphate receptor agonist, FTY720, restores coronary flow reserve in diabetic rats. 2014 Circ. J. pmid:25319164
Park K et al. The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. 2014 J. Nutr. Biochem. pmid:24768661
Schaper K et al. Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells. 2014 Mol. Immunol. pmid:24434636
Fukui H et al. S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. 2014 Dev. Cell pmid:25313964
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Fernández-Pisonero I et al. Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells. 2014 PLoS ONE pmid:25275309
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Sassoli C et al. Mesenchymal stromal cell secreted sphingosine 1-phosphate (S1P) exerts a stimulatory effect on skeletal myoblast proliferation. 2014 PLoS ONE pmid:25264785
Liu M et al. Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein. 2014 J. Biol. Chem. pmid:24318881
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Hirata N et al. Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. 2014 Nat Commun pmid:25254944
Iino J et al. Platelet-derived sphingosine 1-phosphate induces migration of Jurkat T cells. 2014 Lipids Health Dis pmid:25253303
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Xiong H et al. SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling. 2014 Oncol. Rep. pmid:25109605
Zhao X et al. Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. 2014 J. Mol. Cell. Cardiol. pmid:25106095
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Awojoodu AO et al. Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD. 2014 Blood pmid:25075126
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Brizuela L et al. Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells. 2014 Mol Oncol pmid:24768038
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Xia JY et al. The adipokine/ceramide axis: key aspects of insulin sensitization. 2014 Biochimie pmid:23969158
Albinet V et al. Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. 2014 Oncogene pmid:23893239