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S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury. |
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Sphingosine-1-phosphate (S1P) activates STAT3 to protect against de novo acute heart failure (AHF). |
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Life Sci. |
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S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. |
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Science |
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Sphingolipid metabolism in cancer signalling and therapy. |
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Nat. Rev. Cancer |
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Sphingosine-1-Phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche. |
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Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients. |
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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia. |
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S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization. |
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Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis. |
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Respirology |
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Eur. J. Clin. Invest. |
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Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. |
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Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. |
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Gastroenterology |
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A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma. |
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Cancer |
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The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period. |
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Chemosphere |
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Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. |
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Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism. |
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Med Res Rev |
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SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. |
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Autophagy |
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Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. |
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Pleiotropic effects of sphingosine-1-phosphate signaling to control human chorionic mesenchymal stem cell physiology. |
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Cell Death Dis |
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Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. |
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Bone |
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Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. |
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Mol Oncol |
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Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. |
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Front Immunol |
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Targeting sphingosine-1-phosphate signaling for cancer therapy. |
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Sci China Life Sci |
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Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. |
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Proc. Natl. Acad. Sci. U.S.A. |
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J. Atheroscler. Thromb. |
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Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. |
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Neuropharmacology |
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The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. |
2017 |
CNS Neurol Disord Drug Targets |
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High-Resolution Expression Profiling of Peripheral Blood CD8 Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. |
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Mol. Neurobiol. |
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Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. |
2017 |
Nature |
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The balance between Gα-Cdc42/Rac and Gα/-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. |
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Mol. Biol. Cell |
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Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. |
2017 |
BMC Genomics |
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A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation. |
2017 |
Int J Mol Sci |
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Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow. |
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Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. |
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Int J Mol Sci |
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Angiogenesis Model of Cornea to Understand the Role of Sphingosine 1-Phosphate. |
2017 |
Methods Mol. Biol. |
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Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes. |
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PLoS ONE |
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Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. |
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Thromb. Res. |
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Evaluation of plasma sphingosine 1-phosphate, hepcidin and cardiovascular damage biomarkers (cardiac troponin I and homocysteine) in rats infected with brucellosis and vaccinated (Rev-1, RB-51). |
2017 |
Microb. Pathog. |
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Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. |
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Mol. Pharmacol. |
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DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion. |
2017 |
Cell Commun. Signal |
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Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling. |
2017 |
Oncotarget |
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Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation. |
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The sphingosine 1-phosphate breakdown product, (2)-hexadecenal, forms protein adducts and glutathione conjugates in vitro. |
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J. Lipid Res. |
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Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. |
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Adv Biol Regul |
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The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis. |
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PLoS ONE |
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Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. |
2017 |
Front Biosci (Landmark Ed) |
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The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. |
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Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation. |
2017 |
Exp. Dermatol. |
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HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. |
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J. Mol. Med. |
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Epithelial cell extrusion: Pathways and pathologies. |
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Semin. Cell Dev. Biol. |
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Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway. |
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Cell. Physiol. Biochem. |
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Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. |
2017 |
Mol. Immunol. |
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Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. |
2017 |
PLoS ONE |
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Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. |
2017 |
Diabetes |
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Fas/S1P crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis. |
2017 |
Biochem. Biophys. Res. Commun. |
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β-Blockade Prevents Post-Ischemic Myocardial Decompensation Via βAR-Dependent Protective Sphingosine-1 Phosphate Signaling. |
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J. Am. Coll. Cardiol. |
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Punsawad C and Viriyavejakul P |
Reduction in serum sphingosine 1-phosphate concentration in malaria. |
2017 |
PLoS ONE |
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The effects of berberine on a murine model of multiple sclerosis and the SPHK1/S1P signaling pathway. |
2017 |
Biochem. Biophys. Res. Commun. |
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Sphingosine-1-Phosphate as the Lymphocyte's Ticket to Ride and Survive. |
2017 |
Dev. Cell |
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Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3β Phosphorylation. |
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Arch. Med. Res. |
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Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology. |
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Crit. Rev. Biochem. Mol. Biol. |
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Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. |
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J. Immunol. |
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High-Density Lipoprotein Regulation of Mitochondrial Function. |
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Adv. Exp. Med. Biol. |
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Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa. |
2017 |
J. Am. Acad. Dermatol. |
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Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. |
2017 |
Nature |
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A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. |
2017 |
Dev. Cell |
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Sphingosine 1-phosphate signaling in bone remodeling: multifaceted roles and therapeutic potential. |
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Expert Opin. Ther. Targets |
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Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy. |
2017 |
Invest. Ophthalmol. Vis. Sci. |
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Sphingosine 1-phosphate - A double edged sword in the brain. |
2017 |
Biochim. Biophys. Acta |
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A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. |
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J Pharm Biomed Anal |
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Sphingosine-1-phosphate induces Ca signaling and CXCL1 release via TRPC6 channel in astrocytes. |
2017 |
Glia |
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Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P) Agonists and Future Perspectives. |
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J. Med. Chem. |
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Sphingosine-1-Phosphate Signaling in Inflammatory Bowel Disease. |
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Trends Mol Med |
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Modulation of sphingosine-1-phosphate in inflammatory bowel disease. |
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Autoimmun Rev |
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Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate. |
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J. Immunol. |
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Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles. |
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J. Steroid Biochem. Mol. Biol. |
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FTY720 Attenuates Angiotensin II-Induced Podocyte Damage via Inhibiting Inflammatory Cytokines. |
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Mediators Inflamm. |
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Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. |
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PLoS Biol. |
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Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. |
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J. Pathol. |
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Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice. |
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Eur. J. Immunol. |
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Sphingosine 1-phosphate signaling axis mediates fibroblast growth factor 2-induced proliferation and survival of murine auditory neuroblasts. |
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Biochim. Biophys. Acta |
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Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients. |
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J. Lipid Res. |
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ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs. |
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J. Physiol. Biochem. |
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HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium. |
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Lipids Health Dis |
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Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. |
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Hum. Mol. Genet. |
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Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. |
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Diabetes |
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Shear stress induces Gα activation independently of G protein-coupled receptor activation in endothelial cells. |
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Am. J. Physiol., Cell Physiol. |
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The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice. |
2017 |
Aging Cell |
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Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes. |
2017 |
Cancer Invest. |
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Involvement of CETP (Cholesteryl Ester Transfer Protein) in the Shift of Sphingosine-1-Phosphate Among Lipoproteins and in the Modulation of its Functions. |
2017 |
Arterioscler. Thromb. Vasc. Biol. |
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