| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pyne NJ et al. | Sphingosine 1-phosphate signalling in cancer. | 2012 | Biochem. Soc. Trans. | pmid:22260672 |
| Jin YX et al. | A strategy for enrichment of the bioactive sphingoid base-1-phosphates produced by Hypericum perforatum L. in a balloon type airlift reactor. | 2012 | Bioresour. Technol. | pmid:22940331 |
| Snider AJ et al. | Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22940715 |
| Moon MH et al. | Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes. | 2012 | Int. J. Mol. Med. | pmid:22992945 |
| Wang S et al. | A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression. | 2012 | Int. J. Biol. Macromol. | pmid:22197795 |
| Armstrong SM et al. | Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac. | 2012 | Am. J. Pathol. | pmid:22203054 |
| Bode C and Gräler MH | Immune regulation by sphingosine 1-phosphate and its receptors. | 2012 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:22159476 |
| Cyster JG and Schwab SR | Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs. | 2012 | Annu. Rev. Immunol. | pmid:22149932 |
| Kurata H et al. | Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22153936 |
| Calise S et al. | Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors. | 2012 | Biochim. Biophys. Acta | pmid:22178384 |
| Balczerski B et al. | Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors. | 2012 | Dev. Biol. | pmid:22185793 |
| Witt W et al. | Sphingosine-1-phosphate induces contraction of valvular interstitial cells from porcine aortic valves. | 2012 | Cardiovasc. Res. | pmid:22232739 |
| Madhunapantula SV et al. | Targeting sphingosine kinase-1 to inhibit melanoma. | 2012 | Pigment Cell Melanoma Res | pmid:22236408 |
| Che W et al. | Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells. | 2012 | Biochim. Biophys. Acta | pmid:22743041 |
| Testai FD et al. | Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage. | 2012 | Stroke | pmid:22713492 |
| GarcÃa-Merino JA and Sánchez AJ | [Basic mechanisms of action of fingolimod in relation to multiple sclerosis]. | 2012 | Rev Neurol | pmid:22718407 |
| Hisano Y et al. | Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells. | 2012 | PLoS ONE | pmid:22723910 |
| Chiba K and Yoshii N | [Pharmacological properties and clinical efficacy of fingolimod hydrochloride (Imusera®/Gilenya®) for the treatment of multiple sclerosis]. | 2012 | Nippon Yakurigaku Zasshi | pmid:22728990 |
| Linke B et al. | Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22732087 |
| Yokoyama K et al. | Decrease of serum sphingosine-1-phosphate levels in hemodialysis patients with secondary hyperparathyroidism treated with cinacalcet. | 2012 | Clin. Nephrol. | pmid:22732343 |
| Sun DF et al. | Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression. | 2012 | Cancer Lett. | pmid:22261335 |
| Park SW et al. | Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury. | 2012 | J. Am. Soc. Nephrol. | pmid:22095950 |
| Duru EA et al. | Role of S-1-P receptors and human vascular smooth muscle cell migration in diabetes and metabolic syndrome. | 2012 | J. Surg. Res. | pmid:22480845 |
| Moberly JB et al. | Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients. | 2012 | J. Neuroimmunol. | pmid:22465063 |
| Li Q et al. | The reduction of allograft arteriosclerosis in intestinal transplant is associated with sphingosine kinase 1/sphingosine-1-phosphate signaling after fish oil treatment. | 2012 | Transplantation | pmid:22466786 |
| von Bismarck P et al. | IKK NBD peptide inhibits LPS induced pulmonary inflammation and alters sphingolipid metabolism in a murine model. | 2012 | Pulm Pharmacol Ther | pmid:22469869 |
| El-Shewy HM et al. | Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells. | 2012 | Mol. Endocrinol. | pmid:22422617 |
| Eisenhoffer GT et al. | Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. | 2012 | Nature | pmid:22504183 |
| Peng P et al. | [Effect of sphingosine-1-phosphate on chemotherapy-induced ovarian damage and on the efficacy of chemotherapy in mice bearing S180 tumor]. | 2012 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:22445989 |
| Podbielska M et al. | Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis. | 2012 | Neurochem. Res. | pmid:22451227 |
| Altay O et al. | Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice. | 2012 | Crit. Care Med. | pmid:22488000 |
| Tian YL et al. | [Research progress of the selective sphingosine-1-phosphate receptor 1 agonists]. | 2012 | Yao Xue Xue Bao | pmid:22493799 |
| Makino Y et al. | Role of sphingosine-1-phosphate inβ-adrenoceptor desensitization via Ca(2+) sensitization in airway smooth muscle. | 2012 | Allergol Int | pmid:22441633 |
| Shi Y et al. | Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. | 2012 | J. Hepatol. | pmid:21756852 |
| Spiegel S et al. | Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy. | 2012 | Oncogene | pmid:21725353 |
| Krishna SM et al. | Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model. | 2012 | Am. J. Pathol. | pmid:22698985 |
| Lee SH et al. | Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humans. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22679064 |
| Kim CH et al. | Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors. | 2012 | Leukemia | pmid:21769103 |
| Obinata H and Hla T | Sphingosine 1-phosphate in coagulation and inflammation. | 2012 | Semin Immunopathol | pmid:21805322 |
| Tencé M et al. | Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists. | 2012 | Cell. Signal. | pmid:21872657 |
| Beech DJ | Integration of transient receptor potential canonical channels with lipids. | 2012 | Acta Physiol (Oxf) | pmid:21624095 |
| Kipp M and Amor S | FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination. | 2012 | Mult. Scler. | pmid:22383435 |
| Fujii Y et al. | Blocking S1P interaction with S1Pâ‚ receptor by a novel competitive S1Pâ‚-selective antagonist inhibits angiogenesis. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22387544 |
| Cantrell Stanford J et al. | Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells. | 2012 | J. Biol. Chem. | pmid:22389505 |
| Liu W et al. | S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition. | 2012 | Exp. Cell Res. | pmid:22406263 |
| Fukuhara S et al. | The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. | 2012 | J. Clin. Invest. | pmid:22406534 |
| Yang F et al. | Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis. | 2012 | Cancer Biol. Ther. | pmid:22406995 |
| Kwak HI et al. | Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation. | 2012 | Angiogenesis | pmid:22407449 |
| Singh AT et al. | Sphingosine-sphingosine-1-phosphate pathway regulates trophoblast differentiation and syncytialization. | 2012 | Reprod. Biomed. Online | pmid:22197131 |
| Pitman MR et al. | Molecular targets of FTY720 (fingolimod). | 2012 | Curr. Mol. Med. | pmid:22834825 |
| Karmouty-Quintana H et al. | Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:22287614 |
| Curry FE et al. | Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22865384 |
| Masuko K et al. | Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis. | 2012 | Int J Rheum Dis | pmid:22898216 |
| Schmitz EI et al. | Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P₃. | 2012 | Mol. Cell. Biochem. | pmid:22899173 |
| Egom EE | A therapeutic approach to hyperglycaemia in the setting of acute myocardial infarction: spotlight on glucagon-like peptide 1. | 2012 | Ther Adv Cardiovasc Dis | pmid:22902834 |
| Liu Q et al. | Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. | 2012 | PLoS ONE | pmid:22848628 |
| Bassoy EY and Baran Y | Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells. | 2012 | Biomed. Pharmacother. | pmid:22326625 |
| Asghar MY et al. | Sphingosine 1-phosphate and human ether-a'-go-go-related gene potassium channels modulate migration in human anaplastic thyroid cancer cells. | 2012 | Endocr. Relat. Cancer | pmid:22889737 |
| Beckham TH et al. | Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. | 2012 | Int. J. Cancer | pmid:22322590 |
| Törnquist K | Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells. | 2012 | Acta Physiol (Oxf) | pmid:21338471 |
| Babahosseini H et al. | Roles of bioactive sphingolipid metabolites in ovarian cancer cell biomechanics. | 2012 | Conf Proc IEEE Eng Med Biol Soc | pmid:23366417 |
| Salata D et al. | [Sphingosine-1-phosphate--molecular maestro]. | 2012 | Postepy Biochem. | pmid:23373414 |
| Japtok L et al. | Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype. | 2012 | PLoS ONE | pmid:23145172 |
| Härmä V et al. | Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models. | 2012 | Oncogene | pmid:21996742 |
| Bieberich E | It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation. | 2012 | Neurochem. Res. | pmid:22246226 |
| Bhattacharya M et al. | IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:22561460 |
| Spohr TC et al. | Sphingosine 1-phosphate-primed astrocytes enhance differentiation of neuronal progenitor cells. | 2012 | J. Neurosci. Res. | pmid:22588662 |
| Parrill AL et al. | Structure of the first sphingosine 1-phosphate receptor. | 2012 | Sci Signal | pmid:22623751 |
| Cuvillier O | [Sphingosine 1-phosphate receptors: from biology to physiopathology]. | 2012 | Med Sci (Paris) | pmid:23171898 |
| Patel SA et al. | Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity. | 2012 | Endocrinology | pmid:22989629 |
| Fernández-Pisonero I et al. | Lipopolysaccharide and sphingosine-1-phosphate cooperate to induce inflammatory molecules and leukocyte adhesion in endothelial cells. | 2012 | J. Immunol. | pmid:23089395 |
| Ma Y et al. | Sphingosine-1-phosphate (S1P) mediates darkness-induced stomatal closure through raising cytosol pH and hydrogen peroxide (Hâ‚‚Oâ‚‚) levels in guard cells in Vicia faba. | 2012 | Sci China Life Sci | pmid:23090064 |
| Taniguchi M et al. | Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway. | 2012 | J. Biol. Chem. | pmid:23035115 |
| Kawashima T et al. | Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts. | 2012 | Eur. J. Pharmacol. | pmid:23041148 |
| Sorci-Thomas MG and Thomas MJ | High density lipoprotein biogenesis, cholesterol efflux, and immune cell function. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:23077142 |
| Yonesu K and Nara F | [Anti-angiogenic effect of bioactive lipid antagonists]. | 2012 | Nippon Rinsho | pmid:23513926 |
| Bieberich E | Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation. | 2012 | Methods Mol. Biol. | pmid:22528448 |
| Callihan P and Hooks SB | Sphingosine-1-phosphate signaling in neural progenitors. | 2012 | Methods Mol. Biol. | pmid:22528449 |
| Su SC and Bayless KJ | Utilizing sphingosine-1-phosphate to stimulate sprouting angiogenesis. | 2012 | Methods Mol. Biol. | pmid:22528450 |
| Lim M et al. | The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries. | 2012 | PLoS ONE | pmid:22532844 |
| Lynch KR | Building a better sphingosine kinase-1 inhibitor. | 2012 | Biochem. J. | pmid:22533672 |
| Mann DL | Sphingosine 1-phosphate as a therapeutic target in heart failure: more questions than answers. | 2012 | Circulation | pmid:22534620 |
| Reina E et al. | Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry. | 2012 | Chem. Phys. Lipids | pmid:22265672 |
| Meissner A et al. | Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure. | 2012 | Circulation | pmid:22534621 |
| Callihan P et al. | Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. | 2012 | Neuropharmacology | pmid:22016110 |
| Maceyka M et al. | Sphingosine-1-phosphate signaling and its role in disease. | 2012 | Trends Cell Biol. | pmid:22001186 |
| Gupta VK et al. | Focus on molecules: Sphingosine 1 Phosphate (S1P). | 2012 | Exp. Eye Res. | pmid:22001715 |
| Lim KG et al. | Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival. | 2012 | Br. J. Pharmacol. | pmid:22251058 |
| Shannon LA et al. | CCR7/CCL19 controls expression of EDG-1 in T cells. | 2012 | J. Biol. Chem. | pmid:22334704 |
| Nunes J et al. | Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection. | 2012 | Br. J. Cancer | pmid:22315056 |
| Shimizu T et al. | Sphingosine-1-phosphate receptor 3 promotes neointimal hyperplasia in mouse iliac-femoral arteries. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22308044 |
| Canals D et al. | Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase. | 2012 | J. Biol. Chem. | pmid:22311981 |
| Knapp M et al. | Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure. | 2012 | Adv Med Sci | pmid:22296975 |
| Nagahashi M et al. | Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. | 2012 | Cancer Res. | pmid:22298596 |
| Ratajczak J et al. | A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient. | 2012 | Leukemia | pmid:22343521 |
| Mascall KS et al. | Sphingosine-1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis. | 2012 | J. Cell. Sci. | pmid:22344262 |
| Hsu A et al. | Sphingosine-1-phosphate receptor-3 signaling up-regulates epidermal growth factor receptor and enhances epidermal growth factor receptor-mediated carcinogenic activities in cultured lung adenocarcinoma cells. | 2012 | Int. J. Oncol. | pmid:22344462 |
| Ruiz-Medina J et al. | GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception. | 2011 Jul-Aug | Neuropharmacology | pmid:21352831 |
| Wang L et al. | FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl. | 2011 | Eur. Respir. J. | pmid:21071472 |
| Highkin MK et al. | High-throughput screening assay for sphingosine kinase inhibitors in whole blood using RapidFire® mass spectrometry. | 2011 | J Biomol Screen | pmid:21297110 |