MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Berdyshev EV et al. | Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal. | 2011 | Anal. Biochem. | pmid:20804717 |
Berdyshev EV et al. | Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. | 2011 | PLoS ONE | pmid:21304987 |
Schuchardt M et al. | Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system. | 2011 | Br. J. Pharmacol. | pmid:21309759 |
Morris MA et al. | Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells. | 2011 | Autoimmunity | pmid:20695767 |
Lépine S et al. | Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. | 2011 | Cell Death Differ. | pmid:20798685 |
Kim MG et al. | CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury. | 2011 | Nephrol. Dial. Transplant. | pmid:20702533 |
Eichner A and Sixt M | Setting the clock for recirculating lymphocytes. | 2011 | Sci Signal | pmid:22067458 |
Okamoto Y et al. | [Cardiovascular function of sphingosine 1-phosphate signaling]. | 2011 | Seikagaku | pmid:21800684 |
Siow D and Wattenberg B | The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism. | 2011 | Crit. Rev. Biochem. Mol. Biol. | pmid:21864225 |
Adyshev DM et al. | Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement. | 2011 | Cell. Signal. | pmid:21864676 |
Selim S et al. | Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions. | 2011 | Clin. Sci. | pmid:21749329 |
Kim DS et al. | Sphingosine-1-phosphate decreases melanin synthesis via microphthalmia-associated transcription factor phosphorylation through the S1P3 receptor subtype. | 2011 | J. Pharm. Pharmacol. | pmid:21749389 |
Kojima K and Inouye K | Activation of matriptase zymogen. | 2011 | J. Biochem. | pmid:21737400 |
AL-Shawaf E et al. | GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels. | 2011 | Cell Calcium | pmid:21742378 |
Bautista-Pérez R et al. | Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats. | 2011 | Diabetes Res. Clin. Pract. | pmid:21775010 |
Cho MC et al. | Involvement of sphingosine-1-phosphate/RhoA/Rho-kinase signaling pathway in corporal fibrosis following cavernous nerve injury in male rats. | 2011 | J Sex Med | pmid:21143420 |
Murakami M et al. | Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription. | 2011 | J. Cell. Biochem. | pmid:21769916 |
Li C et al. | Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. | 2011 | J. Hepatol. | pmid:21145832 |
Zhao Y et al. | Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21148740 |
Lai WQ et al. | Sphingosine kinase and sphingosine 1-phosphate in asthma. | 2011 | Biosci. Rep. | pmid:21091442 |
Sabbadini RA | Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration. | 2011 | Br. J. Pharmacol. | pmid:21091645 |
Lee YS et al. | Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G(2) /M phase arrest. | 2011 | Cell Prolif. | pmid:21645154 |
Zhao Z et al. | Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions. | 2011 | J. Biomed. Sci. | pmid:21645412 |
Kim ES et al. | Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Gαq coupling. | 2011 | J. Cell. Sci. | pmid:21652634 |
Lim KG et al. | (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. | 2011 | Cell. Signal. | pmid:21620961 |
Egom EE et al. | Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21705677 |
Yangyuoru PM et al. | Determination of sphingosine kinase 2 activity using fluorescent sphingosine by capillary electrophoresis. | 2011 | Electrophoresis | pmid:21706498 |
Kawahara A | [Genetic dissection of cardiac morphogenesis in zebrafish]. | 2011 | Seikagaku | pmid:21706872 |
Burns TA and Luberto C | Sphingolipid metabolism and leukemia: a potential for novel therapeutic approaches. | 2011 | Anticancer Agents Med Chem | pmid:21707485 |
Blaho VA and Hla T | Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. | 2011 | Chem. Rev. | pmid:21939239 |
Schulze T et al. | Sphingosine-1-phospate receptor 4 (S1Pâ‚„) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model. | 2011 | FASEB J. | pmid:21825036 |
Huwiler A et al. | A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. | 2011 | PLoS ONE | pmid:21829623 |
Liu D et al. | Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21734188 |
Li MH et al. | Sphingolipid modulation of angiogenic factor expression in neuroblastoma. | 2011 | Cancer Prev Res (Phila) | pmid:21576349 |
Bréart B et al. | Lipid phosphate phosphatase 3 enables efficient thymic egress. | 2011 | J. Exp. Med. | pmid:21576386 |
Gu Y et al. | Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway. | 2011 | J. Cell Biol. | pmid:21555463 |
Oo ML et al. | Engagement of S1Pâ‚-degradative mechanisms leads to vascular leak in mice. | 2011 | J. Clin. Invest. | pmid:21555855 |
Baranowski M et al. | Exercise increases plasma levels of sphingoid base-1 phosphates in humans. | 2011 | Acta Physiol (Oxf) | pmid:21535416 |
Kanno T and Nishizaki T | Endogenous sphingosine 1-phosphate regulates spontaneous glutamate release from mossy fiber terminals via S1P(3) receptors. | 2011 | Life Sci. | pmid:21683714 |
Kumar A et al. | S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. | 2011 | Cell Death Dis | pmid:21368890 |
Schröder M et al. | The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. | 2011 | Mol. Immunol. | pmid:21435724 |
Kujjo LL et al. | Chemotherapy-induced late transgenerational effects in mice. | 2011 | PLoS ONE | pmid:21437292 |
Bandhuvula P et al. | S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21335477 |
Jenkins RW et al. | Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. | 2011 | J. Biol. Chem. | pmid:21335555 |
Pinschewer DD et al. | Impact of sphingosine 1-phosphate modulation on immune outcomes. | 2011 | Neurology | pmid:21339486 |
Mehling M et al. | Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis. | 2011 | Neurology | pmid:21339487 |
Hla T and Brinkmann V | Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. | 2011 | Neurology | pmid:21339489 |
Soliven B et al. | The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. | 2011 | Neurology | pmid:21339490 |
Pyne S and Pyne NJ | Translational aspects of sphingosine 1-phosphate biology. | 2011 | Trends Mol Med | pmid:21514226 |
Strub GM et al. | Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. | 2011 | FASEB J. | pmid:20959514 |
Sekine Y et al. | HDL and sphingosine-1-phosphate activate stat3 in prostate cancer DU145 cells via ERK1/2 and S1P receptors, and promote cell migration and invasion. | 2011 | Prostate | pmid:20979115 |
Noguchi K and Chun J | Roles for lysophospholipid S1P receptors in multiple sclerosis. | 2011 | Crit. Rev. Biochem. Mol. Biol. | pmid:20979571 |
Becker S et al. | Follicular fluid high-density lipoprotein-associated sphingosine 1-phosphate (S1P) promotes human granulosa lutein cell migration via S1P receptor type 3 and small G-protein RAC1. | 2011 | Biol. Reprod. | pmid:20980685 |
Barra V et al. | Apoptotic cell-derived factors induce arginase II expression in murine macrophages by activating ERK5/CREB. | 2011 | Cell. Mol. Life Sci. | pmid:20949368 |
Bouma HR et al. | Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21245336 |
Aarthi JJ et al. | Dissecting the role of the S1P/S1PR axis in health and disease. | 2011 | J. Dent. Res. | pmid:21248363 |
Sumida GM and Stamer WD | S1Pâ‚‚ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21289286 |
Sensken SC et al. | Local inactivation of sphingosine 1-phosphate in lymph nodes induces lymphopenia. | 2011 | J. Immunol. | pmid:21289303 |
Lee SY et al. | Sphingosine-1-phosphate reduces hepatic ischaemia/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice. | 2011 | Nephrology (Carlton) | pmid:21272128 |
Allende ML et al. | Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. | 2011 | J. Biol. Chem. | pmid:21173151 |
Jeffery DR et al. | Fingolimod for the treatment of relapsing multiple sclerosis. | 2011 | Expert Rev Neurother | pmid:21158700 |
Chi H | Sphingosine-1-phosphate and immune regulation: trafficking and beyond. | 2011 | Trends Pharmacol. Sci. | pmid:21159389 |
Jee BC et al. | Dose-dependent effect of sphingosine-1-phosphate in mouse oocyte maturation medium on subsequent embryo development. | 2011 | Gynecol. Obstet. Invest. | pmid:21160167 |
Kim YM et al. | G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21212405 |
Kharel Y et al. | A rapid assay for assessment of sphingosine kinase inhibitors and substrates. | 2011 | Anal. Biochem. | pmid:21216217 |
Gaveglio VL et al. | Metabolic pathways for the degradation of phosphatidic acid in isolated nuclei from cerebellar cells. | 2011 | Arch. Biochem. Biophys. | pmid:21216221 |
Ter Braak M et al. | Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator. | 2011 | Biochem. Pharmacol. | pmid:21163254 |
Markiewicz M et al. | Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells. | 2011 | Microcirculation | pmid:21166920 |
Fenger M et al. | Genetics of the ceramide/sphingosine-1-phosphate rheostat in blood pressure regulation and hypertension. | 2011 | BMC Genet. | pmid:21569466 |
Separovic D et al. | Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21545791 |
Spiegel S and Milstien S | The outs and the ins of sphingosine-1-phosphate in immunity. | 2011 | Nat. Rev. Immunol. | pmid:21546914 |
Argraves KM et al. | S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease. | 2011 | Lipids Health Dis | pmid:21554699 |
Soleimani R et al. | Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. | 2011 | PLoS ONE | pmid:21559342 |
Finney CA et al. | S1P is associated with protection in human and experimental cerebral malaria. | 2011 | Mol. Med. | pmid:21556483 |
Bradley ME et al. | The in vitro metabolism of sphingosine-1-phosphate: identification; inhibition and pharmacological implications. | 2011 | Eur. J. Pharmacol. | pmid:21970805 |
Kartal M et al. | Resveratrol triggers apoptosis through regulating ceramide metabolizing genes in human K562 chronic myeloid leukemia cells. | 2011 | Nutr Cancer | pmid:21500096 |
Serebrov VIu et al. | [Activity of the sphingomyelin cycle enzymes and concentration of products of sphingomyelin degradation in the rat liver in the course of acute toxic hepatitis]. | 2010 Mar-Apr | Biomed Khim | pmid:21341516 |
Bektas M et al. | Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. | 2010 | J. Biol. Chem. | pmid:20097939 |
Riccio A | New endogenous regulators of class I histone deacetylases. | 2010 | Sci Signal | pmid:20051592 |
Brown M et al. | Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium. | 2010 | Microvasc. Res. | pmid:20053363 |
Fletcher JI et al. | ABC transporters in cancer: more than just drug efflux pumps. | 2010 | Nat. Rev. Cancer | pmid:20075923 |
Brakch N et al. | Evidence for a role of sphingosine-1 phosphate in cardiovascular remodelling in Fabry disease. | 2010 | Eur. Heart J. | pmid:19773225 |
Nishimura B et al. | The influences of sphingolipid metabolites on gentamicin-induced hair cell loss of the rat cochlea. | 2010 | Neurosci. Lett. | pmid:20709153 |
Swan DJ et al. | Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation. | 2010 | J. Cell. Mol. Med. | pmid:20716131 |
Blachnio-Zabielska A et al. | Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle. | 2010 | J. Cell. Physiol. | pmid:20568228 |
Qi X et al. | Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice. | 2010 | Eur. J. Pharmacol. | pmid:20206620 |
Xu R et al. | Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes. | 2010 | FASEB J. | pmid:20207939 |
Hu WM et al. | Effect of S1P5 on proliferation and migration of human esophageal cancer cells. | 2010 | World J. Gastroenterol. | pmid:20397263 |
Kanno T et al. | Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus. | 2010 | Neuroscience | pmid:20950672 |
Browne CD et al. | SHEP1 partners with CasL to promote marginal zone B-cell maturation. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20956287 |
Zhang N et al. | FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy. | 2010 | Autophagy | pmid:20935520 |
Mair KM et al. | Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. | 2010 | Br. J. Pharmacol. | pmid:20718749 |
Park SW et al. | Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. | 2010 | Lab. Invest. | pmid:20458275 |
Itoh R et al. | Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells. | 2010 | J. Bone Miner. Metab. | pmid:20458606 |
Yoshida T et al. | Therapeutic angiogenesis by implantation of a capillary structure constituted of human adipose tissue microvascular endothelial cells. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20431071 |
Long JS et al. | Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells. | 2010 | Mol. Cell. Biol. | pmid:20516217 |
Seo YJ et al. | Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity. | 2010 | J. Virol. | pmid:20519401 |
Lee MH et al. | HDL3, but not HDL2, stimulates plasminogen activator inhibitor-1 release from adipocytes: the role of sphingosine-1-phosphate. | 2010 | J. Lipid Res. | pmid:20522601 |
Blom T et al. | An autocrine sphingosine-1-phosphate signaling loop enhances NF-kappaB-activation and survival. | 2010 | BMC Cell Biol. | pmid:20573281 |
Zabielski P et al. | The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20599517 |