MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hardin C et al. | Glassy dynamics, cell mechanics, and endothelial permeability. | 2013 | J Phys Chem B | pmid:23638866 |
Wang H et al. | Potential serum biomarkers from a metabolomics study of autism. | 2016 | J Psychiatry Neurosci | pmid:26395811 |
Surya VN et al. | Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress. | 2016 | J R Soc Interface | pmid:27974574 |
Jiang H et al. | Application of ultra-performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription. | 2012 | J Sep Sci | pmid:22282408 |
Cho MC et al. | Involvement of sphingosine-1-phosphate/RhoA/Rho-kinase signaling pathway in corporal fibrosis following cavernous nerve injury in male rats. | 2011 | J Sex Med | pmid:21143420 |
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Zhang BL et al. | Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors. | 2012 | J Zhejiang Univ Sci B | pmid:22761247 |
Price MM et al. | A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. | 2013 | J. Allergy Clin. Immunol. | pmid:22939756 |
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Dany M and Elston D | Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa. | 2017 | J. Am. Acad. Dermatol. | pmid:28551069 |
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Abuhusain HJ et al. | A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis. | 2013 | J. Biol. Chem. | pmid:24265321 |
Dudek SM et al. | Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase. | 2004 | J. Biol. Chem. | pmid:15056655 |
Gorshkova I et al. | Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1. | 2008 | J. Biol. Chem. | pmid:18296444 |
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Leclercq TM et al. | Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity. | 2008 | J. Biol. Chem. | pmid:18263879 |
Nakamura H et al. | Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells. | 1998 | J. Biol. Chem. | pmid:9624115 |
Su SC et al. | Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity. | 2010 | J. Biol. Chem. | pmid:20947498 |
Fujiwara Y et al. | Identification of the hydrophobic ligand binding pocket of the S1P1 receptor. | 2007 | J. Biol. Chem. | pmid:17114791 |
Lee JF et al. | Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. | 2006 | J. Biol. Chem. | pmid:16891661 |
Park ES et al. | Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction. | 2015 | J. Biol. Chem. | pmid:25716317 |
Ki SH et al. | Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha. | 2007 | J. Biol. Chem. | pmid:17098744 |
Usui S et al. | Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. | 2004 | J. Biol. Chem. | pmid:14711826 |
Liu M et al. | Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles. | 2015 | J. Biol. Chem. | pmid:25627684 |
Zeidan YH et al. | Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. | 2006 | J. Biol. Chem. | pmid:16803890 |
Paik JH et al. | Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. | 2001 | J. Biol. Chem. | pmid:11150298 |
Xia P et al. | Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. | 1999 | J. Biol. Chem. | pmid:10567432 |
Im DS et al. | Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. | 2000 | J. Biol. Chem. | pmid:10799507 |
Cantrell Stanford J et al. | Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells. | 2012 | J. Biol. Chem. | pmid:22389505 |
van Meeteren LA et al. | Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. | 2005 | J. Biol. Chem. | pmid:15769751 |
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Cuvillier O et al. | Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes. | 1998 | J. Biol. Chem. | pmid:9446602 |
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