MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sattler K and Levkau B | Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection. | 2009 | Cardiovasc. Res. | pmid:19233866 |
Igarashi J and Michel T | Sphingosine-1-phosphate and modulation of vascular tone. | 2009 | Cardiovasc. Res. | pmid:19233865 |
Garcia JG | Concepts in microvascular endothelial barrier regulation in health and disease. | 2009 | Microvasc. Res. | pmid:19232241 |
Gellings Lowe N et al. | Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts. | 2009 | Cardiovasc. Res. | pmid:19228708 |
Rodgers A et al. | Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells. | 2009 | Stem Cells Dev. | pmid:19228106 |
Bedia C et al. | Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity. | 2009 | Chembiochem | pmid:19226506 |
Choi SK et al. | Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery. | 2009 | Cardiovasc. Res. | pmid:19218288 |
Salinas NR et al. | Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720. | 2009 | Pathol. Oncol. Res. | pmid:19214784 |
Thathiah A et al. | The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. | 2009 | Science | pmid:19213921 |
Hla T and Im DS | Cell biology. The ABCs of lipophile transport. | 2009 | Science | pmid:19213902 |
Gillies L et al. | The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. | 2009 | Cell. Signal. | pmid:19211033 |
Zhang ZY et al. | FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis. | 2009 | Neuropathol. Appl. Neurobiol. | pmid:19207263 |
Ishii M et al. | Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. | 2009 | Nature | pmid:19204730 |
Reines I et al. | Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration. | 2009 | J. Invest. Dermatol. | pmid:19194476 |
Sensken SC and Gräler MH | [Sphingolipids and their medical impact]. | 2009 | Dtsch. Med. Wochenschr. | pmid:19180419 |
Kuehnel MP et al. | Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumen. | 2009 | J. Cell. Sci. | pmid:19174471 |
Kuehnel MP et al. | Sphingosine-1-phosphate receptors stimulate macrophage plasma-membrane actin assembly via ADP release, ATP synthesis and P2X7R activation. | 2009 | J. Cell. Sci. | pmid:19174470 |
Wadgaonkar R et al. | Differential regulation of sphingosine kinases 1 and 2 in lung injury. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19168577 |
Benamer N et al. | Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts. | 2009 | J. Mol. Cell. Cardiol. | pmid:19166858 |
Gaengel K et al. | Endothelial-mural cell signaling in vascular development and angiogenesis. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19164813 |
Liao JJ et al. | Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor. | 2009 | FASEB J. | pmid:19158154 |
Frias MA et al. | Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate. | 2009 | Cardiovasc. Res. | pmid:19151362 |
Yonesu K et al. | Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog. | 2009 | Biochem. Pharmacol. | pmid:19150609 |
Young N et al. | Sphingosine-1-phosphate regulates glioblastoma cell invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61. | 2009 | Mol. Cancer Res. | pmid:19147534 |
Gérard A et al. | The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration. | 2009 | Blood | pmid:19139083 |
Li MH et al. | S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. | 2009 | Cancer Lett. | pmid:19131156 |
Weis N et al. | Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants. | 2009 | Mol. Biol. Cell | pmid:19129475 |
Vogel P et al. | Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. | 2009 | PLoS ONE | pmid:19119317 |
Berdyshev EV et al. | FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. | 2009 | J. Biol. Chem. | pmid:19119142 |
Bergelin N et al. | Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2. | 2009 | Endocrinology | pmid:19116345 |
Jang C et al. | Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19112163 |
Whetzel AM et al. | Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19091959 |
Lagadari M et al. | Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling. | 2009 | Int. J. Oncol. | pmid:19082500 |
Evindar G et al. | Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19081720 |
Roztocil E et al. | Mechanisms of sphingosine-1-phosphate-induced akt-dependent smooth muscle cell migration. | 2009 | Surgery | pmid:19081473 |
Pederson L et al. | Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19075223 |
Kawahara A et al. | The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. | 2009 | Science | pmid:19074308 |
Kirby RJ et al. | Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19073640 |
Kennedy S et al. | Targeting sphingosine-1-phosphate signalling for cardioprotection. | 2009 | Curr Opin Pharmacol | pmid:19070545 |
Brindley DN and Pilquil C | Lipid phosphate phosphatases and signaling. | 2009 | J. Lipid Res. | pmid:19066402 |
Osborne N et al. | The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. | 2008 | Curr. Biol. | pmid:19062281 |
Padmanabhan S et al. | Constitutively active GPR6 is located in the intracellular compartments. | 2009 | FEBS Lett. | pmid:19059244 |
Chung FY et al. | Signaling mechanisms of sphingosine 1-phosphate-induced ERK1/2 activation in cultured feline esophageal smooth muscle cells. | 2008 | Arch. Pharm. Res. | pmid:19023540 |
Hashimoto T et al. | Sphingosine kinase is induced in mouse 3T3-L1 cells and promotes adipogenesis. | 2009 | J. Lipid Res. | pmid:19020339 |
Lai WQ et al. | Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis. | 2008 | J. Immunol. | pmid:19017993 |
Bansal G et al. | RGS13 controls g protein-coupled receptor-evoked responses of human mast cells. | 2008 | J. Immunol. | pmid:19017978 |
Karliner JS | Sphingosine kinase regulation and cardioprotection. | 2009 | Cardiovasc. Res. | pmid:19017750 |
Foster DJ et al. | Muscarinic receptor regulation of osmosensitive taurine transport in human SH-SY5Y neuroblastoma cells. | 2009 | J. Neurochem. | pmid:19012745 |
Lee JF et al. | Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature. | 2009 | Am. J. Physiol. Heart Circ. Physiol. | pmid:19011048 |
Szczepaniak WS et al. | Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo. | 2008 | Transl Res | pmid:19010292 |
Maeurer C et al. | Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM. | 2009 | Cell. Signal. | pmid:19000755 |
Severinson E | WASp stings mature lymphocytes. | 2008 | Blood | pmid:18988873 |
Maceyka M et al. | Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling. | 2009 | J. Lipid Res. | pmid:18987387 |
Kimura T et al. | Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. | 2008 | J. Immunol. | pmid:18981156 |
Asada S et al. | Downregulation of Dicer expression by serum withdrawal sensitizes human endothelial cells to apoptosis. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18978195 |
Michaelson LV et al. | Functional characterization of a higher plant sphingolipid Delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis. | 2009 | Plant Physiol. | pmid:18978071 |
Wang L and Dudek SM | Regulation of vascular permeability by sphingosine 1-phosphate. | 2009 | Microvasc. Res. | pmid:18973762 |
Jo SK et al. | Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. | 2009 | Kidney Int. | pmid:18971925 |
Ranty ML et al. | Ceramide production associated with retinal apoptosis after retinal detachment. | 2009 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:18958490 |
Nicol GD | Nerve growth factor, sphingomyelins, and sensitization in sensory neurons. | 2008 | Sheng Li Xue Bao | pmid:18958367 |
Ikeda H et al. | Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. | 2009 | J. Lipid Res. | pmid:18955732 |
Satoh Y et al. | Regulation by sphingolipids of the fate of FRTL-5 cells. | 2009 | J. Biochem. | pmid:18953023 |
Hinkovska-Galcheva V et al. | The role of sphingosine-1-phosphate and ceramide-1-phosphate in calcium homeostasis. | 2008 | Curr Opin Investig Drugs | pmid:18951299 |
Rohatagi S et al. | Use of an exposure-response model to aid early drug development of an oral sphingosine 1-phosphate receptor modulator. | 2009 | J Clin Pharmacol | pmid:18948412 |
Estrada R et al. | Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells. | 2009 | Histochem. Cell Biol. | pmid:18936953 |
Chien CC et al. | Activation of telomerase and cyclooxygenase-2 in PDGF and FGF inhibition of C2-ceramide-induced apoptosis. | 2009 | J. Cell. Physiol. | pmid:18932216 |
van der Giet M et al. | Relevance and potential of sphingosine-1-phosphate in vascular inflammatory disease. | 2008 | Biol. Chem. | pmid:18925828 |
Ohuchi H et al. | Expression patterns of the lysophospholipid receptor genes during mouse early development. | 2008 | Dev. Dyn. | pmid:18924241 |
Li MH et al. | Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. | 2008 | Mol. Cancer Res. | pmid:18922980 |
Tauseef M et al. | Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells. | 2008 | Circ. Res. | pmid:18849324 |
Kawamori T et al. | Role for sphingosine kinase 1 in colon carcinogenesis. | 2009 | FASEB J. | pmid:18824518 |
Bryan L et al. | Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness. | 2008 | Mol. Cancer Res. | pmid:18819934 |
Roelofsen T et al. | Sphingosine-1-phosphate acts as a developmental stage specific inhibitor of platelet-derived growth factor-induced chemotaxis of osteoblasts. | 2008 | J. Cell. Biochem. | pmid:18819098 |
Snider AJ et al. | A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. | 2009 | FASEB J. | pmid:18815359 |
Kang H et al. | Fluid shear stress modulates endothelial cell invasion into three-dimensional collagen matrices. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18805898 |
Coste O et al. | Sphingosine 1-phosphate modulates spinal nociceptive processing. | 2008 | J. Biol. Chem. | pmid:18805787 |
Rivera J et al. | The alliance of sphingosine-1-phosphate and its receptors in immunity. | 2008 | Nat. Rev. Immunol. | pmid:18787560 |
Xie B et al. | Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization. | 2009 | J. Cell. Physiol. | pmid:18781584 |
Zebol JR et al. | The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1. | 2009 | Int. J. Biochem. Cell Biol. | pmid:18775504 |
Westerberg LS et al. | WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function. | 2008 | Blood | pmid:18772454 |
Rivera J et al. | New insights on mast cell activation via the high affinity receptor for IgE. | 2008 | Adv. Immunol. | pmid:18772004 |
Jessup W | Lipid metabolism: sources and stability of plasma sphingosine-1-phosphate. | 2008 | Curr. Opin. Lipidol. | pmid:18769238 |
Pyne S et al. | Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. | 2009 | Cell. Signal. | pmid:18768158 |
Ryser MF et al. | S1P(1) overexpression stimulates S1P-dependent chemotaxis of human CD34+ hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homing. | 2008 | Mol. Immunol. | pmid:18760838 |
Kimura A et al. | Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain. | 2008 | Stroke | pmid:18757288 |
Okajima F et al. | Anti-atherogenic actions of high-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor class B type I. | 2009 | Endocr. J. | pmid:18753704 |
Billich A and Baumruker T | Sphingolipid metabolizing enzymes as novel therapeutic targets. | 2008 | Subcell. Biochem. | pmid:18751924 |
Saddoughi SA et al. | Roles of bioactive sphingolipids in cancer biology and therapeutics. | 2008 | Subcell. Biochem. | pmid:18751921 |
Lucki NC and Sewer MB | Multiple roles for sphingolipids in steroid hormone biosynthesis. | 2008 | Subcell. Biochem. | pmid:18751920 |
Serrano-Sanchez M et al. | Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of cyclooxygenase 2. | 2008 | Endocrinology | pmid:18723875 |
Caballero S et al. | Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization. | 2009 | Exp. Eye Res. | pmid:18723015 |
Huang WR et al. | [SphK-1/S1P signal pathway in CML cells]. | 2008 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:18718048 |
Vessey DA et al. | Combined sphingosine, S1P and ischemic postconditioning rescue the heart after protracted ischemia. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18706887 |
Ohama T et al. | Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18703638 |
Shida D et al. | Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. | 2008 | Cancer Res. | pmid:18701480 |
Okada T et al. | Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system. | 2009 | Cell. Signal. | pmid:18694820 |
Zeidan YH et al. | Molecular targeting of acid ceramidase: implications to cancer therapy. | 2008 | Curr Drug Targets | pmid:18691012 |
Swaney JS et al. | Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye. | 2008 | Exp. Eye Res. | pmid:18687328 |
Alvero AB et al. | Anti-tumor activity of phenoxodiol: from bench to clinic. | 2008 | Future Oncol | pmid:18684059 |
Tanaka R et al. | Cell-culture-dependent change of Ca2+ response of rat aortic myocytes to sphingosine-1-phosphate. | 2008 | J. Pharmacol. Sci. | pmid:18678983 |