Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

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Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Lung Neoplasms D008175 171 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Authors Title Published Journal PubMed Link
Radi ZA and Vogel MW Gastric parietal cell atrophy and depletion after administration of a sphingosine-1-phosphate 1 inhibitor. 2014 Toxicol Pathol pmid:24178572
Yu Y et al. Phospholipid transfer protein deficiency decreases the content of S1P in HDL via the loss of its transfer capability. 2014 Lipids pmid:24158769
Giannouli CC et al. Visualizing S1P-directed cellular egress by intravital imaging. 2014 Biochim. Biophys. Acta pmid:24090699
Zhang Y et al. Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. 2014 J. Clin. Invest. pmid:24837436
Kurano M et al. Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate. 2014 Biochim. Biophys. Acta pmid:24814049
Arya D et al. Sphingosine-1-phosphate promotes the differentiation of adipose-derived stem cells into endothelial nitric oxide synthase (eNOS) expressing endothelial-like cells. 2014 J. Biomed. Sci. pmid:24898615
Maceyka M and Spiegel S Sphingolipid metabolites in inflammatory disease. 2014 Nature pmid:24899305
Nagata Y et al. Sphingosine-1-phosphate mediates epidermal growth factor-induced muscle satellite cell activation. 2014 Exp. Cell Res. pmid:24960577
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Moxon JV et al. Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease. 2014 Circ Cardiovasc Genet pmid:24448739
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Kang JW and Lee SM Impaired expression of caveolin-1 contributes to hepatic ischemia and reperfusion injury. 2014 Biochem. Biophys. Res. Commun. pmid:24997335
Ohotski J et al. Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4. 2014 Cell. Signal. pmid:24486401
Snider AJ et al. Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease. 2014 PLoS ONE pmid:25460165
Takeo T et al. Investigations of motility and fertilization potential in thawed cryopreserved mouse sperm from cold-stored epididymides. 2014 Cryobiology pmid:24201107
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Nakanaga K et al. Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo. 2014 J. Biochem. pmid:24451492
Langeslag M et al. Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons. 2014 Mol Pain pmid:25431213
Tibboel J et al. Sphingolipids in lung growth and repair. 2014 Chest pmid:24394822
Kim YI et al. An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. 2014 Mol. Cell. Biol. pmid:25312644
Huang K et al. AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose. 2014 Cell. Signal. pmid:24342046
Slattum G et al. Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P. 2014 Curr. Biol. pmid:24361067
Wang F and Ye P Improving heart function by modulating myocardiocyte autophagy: a possible novel mechanism for cardiovascular protection of high-density lipoprotein. 2014 Lipids Health Dis pmid:25339382
Keller J et al. Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts. 2014 Nat Commun pmid:25333900
Lepletier A et al. Early double-negative thymocyte export in Trypanosoma cruzi infection is restricted by sphingosine receptors and associated with human chagas disease. 2014 PLoS Negl Trop Dis pmid:25330249
Bradley E et al. Critical role of Spns2, a sphingosine-1-phosphate transporter, in lung cancer cell survival and migration. 2014 PLoS ONE pmid:25330231
Xu H et al. Sphingosine-1-phosphate receptor agonist, FTY720, restores coronary flow reserve in diabetic rats. 2014 Circ. J. pmid:25319164
Park K et al. The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. 2014 J. Nutr. Biochem. pmid:24768661
Fukui H et al. S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. 2014 Dev. Cell pmid:25313964
Obinata H et al. Individual variation of human S1P₁ coding sequence leads to heterogeneity in receptor function and drug interactions. 2014 J. Lipid Res. pmid:25293589
Fernández-Pisonero I et al. Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells. 2014 PLoS ONE pmid:25275309
Sassoli C et al. Mesenchymal stromal cell secreted sphingosine 1-phosphate (S1P) exerts a stimulatory effect on skeletal myoblast proliferation. 2014 PLoS ONE pmid:25264785
Silva VR et al. Hypothalamic S1P/S1PR1 axis controls energy homeostasis. 2014 Nat Commun pmid:25255053
Li F et al. Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death. 2014 Hum. Reprod. pmid:24221908
Hirata N et al. Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. 2014 Nat Commun pmid:25254944
Bigaud M et al. Second generation S1P pathway modulators: research strategies and clinical developments. 2014 Biochim. Biophys. Acta pmid:24239768
Iino J et al. Platelet-derived sphingosine 1-phosphate induces migration of Jurkat T cells. 2014 Lipids Health Dis pmid:25253303
Huang YL et al. Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells. 2014 Cell. Signal. pmid:24333325
Emery SM et al. Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells. 2014 J. Pharmacol. Exp. Ther. pmid:24259678
Adamson RH et al. Albumin modulates S1P delivery from red blood cells in perfused microvessels: mechanism of the protein effect. 2014 Am. J. Physiol. Heart Circ. Physiol. pmid:24531813
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Hanson MA and Peach R Structural biology of the S1P1 receptor. 2014 Curr. Top. Microbiol. Immunol. pmid:24728592
Cahalan SM Chemical and genetic tools to explore S1P biology. 2014 Curr. Top. Microbiol. Immunol. pmid:24728593
Arnon TI and Cyster JG Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen. 2014 Curr. Top. Microbiol. Immunol. pmid:24728595
Oldstone MB and Rosen H Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule. 2014 Curr. Top. Microbiol. Immunol. pmid:24728596
Martin R and Sospedra M Sphingosine-1 phosphate and central nervous system. 2014 Curr. Top. Microbiol. Immunol. pmid:24728597
Shayegi N et al. CXCR4 blockade and sphingosine-1-phosphate activation facilitate engraftment of haematopoietic stem and progenitor cells in a non-myeloablative transplant model. 2014 Br. J. Haematol. pmid:24180707
Ogle ME et al. Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. 2014 Acta Biomater pmid:25128750
Bi Y et al. Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth. 2014 Am. J. Pathol. pmid:25111230
Ishitsuka A et al. FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression. 2014 Int. J. Mol. Med. pmid:25109763
Xiong H et al. SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling. 2014 Oncol. Rep. pmid:25109605
Rolin J and Maghazachi AA Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis. 2014 J. Leukoc. Biol. pmid:24493826
Zhao X et al. Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. 2014 J. Mol. Cell. Cardiol. pmid:25106095
Li MH et al. Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma. 2014 J. Pediatr. Surg. pmid:25092091
Awojoodu AO et al. Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD. 2014 Blood pmid:25075126
Belvitch P et al. Proline-rich region of non-muscle myosin light chain kinase modulates kinase activity and endothelial cytoskeletal dynamics. 2014 Microvasc. Res. pmid:25072537
Mendes-da-Cruz DA et al. Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. 2014 PLoS ONE pmid:25068647
Moon MH et al. Sphingosine-1-phosphate inhibits the adipogenic differentiation of 3T3-L1 preadipocytes. 2014 Int. J. Mol. Med. pmid:25050633
Wakashima T et al. Dual functions of the trans-2-enoyl-CoA reductase TER in the sphingosine 1-phosphate metabolic pathway and in fatty acid elongation. 2014 J. Biol. Chem. pmid:25049234
Marfia G et al. Autocrine/paracrine sphingosine-1-phosphate fuels proliferative and stemness qualities of glioblastoma stem cells. 2014 Glia pmid:25042636
Schwalm S et al. Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. 2014 Basic Clin. Pharmacol. Toxicol. pmid:23789924
Tsai YC et al. Antiapoptotic agent sphingosine-1-phosphate protects vitrified murine ovarian grafts. 2014 Reprod Sci pmid:23793475
Xiong Y and Hla T S1P control of endothelial integrity. 2014 Curr. Top. Microbiol. Immunol. pmid:24728594
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Rahman MM et al. Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids. 2014 PLoS ONE pmid:24647471
Park SM et al. Sphingosine-1-phosphate lyase is expressed by CD68+ cells on the parenchymal side of marginal reticular cells in human lymph nodes. 2014 Eur. J. Immunol. pmid:24825162
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Chawla S et al. Exogenous sphingosine-1-phosphate boosts acclimatization in rats exposed to acute hypobaric hypoxia: assessment of haematological and metabolic effects. 2014 PLoS ONE pmid:24887065
Janes K et al. The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. 2014 J. Biol. Chem. pmid:24876379
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Couttas TA et al. Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis. 2014 Acta Neuropathol Commun pmid:24456642
Gassowska M et al. Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells. 2014 Neurochem. Res. pmid:24452756
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Fujii K et al. Sphingosine 1-phosphate increases an intracellular Ca(2+) concentration via S1P3 receptor in cultured vascular smooth muscle cells. 2014 J. Pharm. Pharmacol. pmid:24450400
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Gil-Ortega M et al. Ex vivo microperfusion system of the adipose organ: a new approach to studying the mobilization of adipose cell populations. 2014 Int J Obes (Lond) pmid:24357852
Maeda Y et al. S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1. 2014 Int. Immunol. pmid:24343820
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Abu El-Asrar AM et al. Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy. 2014 Lipids Health Dis pmid:25496321
Zeng Y et al. Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding. 2014 Am. J. Physiol. Heart Circ. Physiol. pmid:24285115
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Nagahashi M et al. Sphingosine-1-phosphate in chronic intestinal inflammation and cancer. 2014 Adv Biol Regul pmid:24210073
Ratajczak MZ et al. The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and cancer cells. 2014 Expert Opin. Ther. Targets pmid:24188167
Chawla S et al. Exogenous sphingosine 1-phosphate protects murine splenocytes against hypoxia-induced injury. 2014 Lipids pmid:24190514