MeSH term | MeSH ID | Detail |
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Farber Lipogranulomatosis | D055577 | 1 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Mastrandrea LD et al. | Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines. | 2005 | Diabetes | pmid:15855330 |
Kim KS et al. | GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. | 2005 | FASEB J. | pmid:15857892 |
Katsuma S et al. | Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells. | 2005 | FEBS Lett. | pmid:15862293 |
Halin C et al. | The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. | 2005 | Blood | pmid:15870184 |
Wu WT et al. | Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells. | 2005 | Endocrinology | pmid:15878967 |
Takeshita A et al. | Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells. | 2005 | J Oral Sci | pmid:15881228 |
Sauer B et al. | Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat. | 2005 | Pharmazie | pmid:15881612 |
Ma Y et al. | Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. | 2005 | J. Biol. Chem. | pmid:15883165 |
Pettus BJ et al. | The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. | 2005 | Mol. Pharmacol. | pmid:15900018 |
Takashiro Y et al. | Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells. | 2005 | Biochem. Pharmacol. | pmid:15907808 |
Yin F and Watsky MA | LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:15914605 |
Pfaff M et al. | Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. | 2005 | Respir. Res. | pmid:15927078 |
Kariya Y et al. | Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis. | 2005 | Genes Cells | pmid:15938718 |
Osawa Y et al. | Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. | 2005 | J. Biol. Chem. | pmid:15946935 |
Ledent C et al. | Premature ovarian aging in mice deficient for Gpr3. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15956199 |
Long J et al. | Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. | 2005 | Biochem. J. | pmid:15960610 |
Li Z et al. | Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15967165 |
Karliner JS | Off the shelf but not mass produced. | 2005 | Chem. Biol. | pmid:15975506 |
Jo E et al. | S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. | 2005 | Chem. Biol. | pmid:15975516 |
Clemens JJ et al. | Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15982878 |
Zaslavsky A et al. | Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells. | 2005 | FEBS Lett. | pmid:15987639 |
Chae SS and Hla T | Inhibition of gene expression in vivo using multiplex siRNA. | 2005 | Methods Mol. Biol. | pmid:15990401 |
Johnstone ED et al. | Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a G(i)-coupled receptor response. | 2005 | J. Lipid Res. | pmid:15995175 |
Rosen H and Goetzl EJ | Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. | 2005 | Nat. Rev. Immunol. | pmid:15999095 |
Abbey-Hosch SE et al. | Differential regulation of NPR-B/GC-B by protein kinase c and calcium. | 2005 | Biochem. Pharmacol. | pmid:16005434 |
Malchinkhuu E et al. | Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells. | 2005 | Oncogene | pmid:16007180 |
Butter JJ et al. | A rapid and validated HPLC method to quantify sphingosine 1-phosphate in human plasma using solid-phase extraction followed by derivatization with fluorescence detection. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16023899 |
Maguire JJ and Davenport AP | Regulation of vascular reactivity by established and emerging GPCRs. | 2005 | Trends Pharmacol. Sci. | pmid:16054240 |
Tani M et al. | Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. | 2005 | J. Lipid Res. | pmid:16061940 |
Pébay A et al. | Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells. | 2005 Nov-Dec | Stem Cells | pmid:16081668 |
Kharel Y et al. | Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. | 2005 | J. Biol. Chem. | pmid:16093248 |
Maceyka M et al. | Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099387 |
Chun J | Lysophospholipids in the nervous system. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099390 |
Rosen H | Chemical approaches to the lysophospholipid receptors. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099402 |
Yopp AC et al. | Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells. | 2005 | J. Immunol. | pmid:16116177 |
Czeloth N et al. | Sphingosine-1-phosphate mediates migration of mature dendritic cells. | 2005 | J. Immunol. | pmid:16116182 |
Bandhuvula P et al. | The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. | 2005 | J. Biol. Chem. | pmid:16118221 |
Foss FW et al. | Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16125386 |
Tani M et al. | Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu. | 2005 | J. Biol. Chem. | pmid:16126722 |
Huang WR et al. | [Effects of sphingosine 1-phosphate on functions of T cell - review]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:16129068 |
Hughes SK et al. | Fluid shear stress modulates cell migration induced by sphingosine 1-phosphate and vascular endothelial growth factor. | 2005 | Ann Biomed Eng | pmid:16133909 |
Kihara A et al. | [Function and metabolism of the bioactive lipid molecule sphingosine 1-phosphate]. | 2005 | Tanpakushitsu Kakusan Koso | pmid:16146193 |
Fieger CB et al. | Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines. | 2005 | FASEB J. | pmid:16148028 |
Hla T | Immunology. Dietary factors and immunological consequences. | 2005 | Science | pmid:16150998 |
Schwab SR et al. | Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. | 2005 | Science | pmid:16151014 |
Hemmings DG et al. | Sphingosine-1-phosphate acts via rho-associated kinase and nitric oxide to regulate human placental vascular tone. | 2006 | Biol. Reprod. | pmid:16162874 |
Armulik A et al. | Endothelial/pericyte interactions. | 2005 | Circ. Res. | pmid:16166562 |
Yamashita H et al. | Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation. | 2006 | J. Surg. Res. | pmid:16183075 |
Sparkman L et al. | Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16183668 |
Urata Y et al. | Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase. | 2005 | Kobe J Med Sci | pmid:16199931 |