MeSH term | MeSH ID | Detail |
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Farber Lipogranulomatosis | D055577 | 1 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cuvillier O | Sphingosine in apoptosis signaling. | 2002 | Biochim. Biophys. Acta | pmid:12531549 |
Osada M et al. | Modulation of sphingosine 1-phosphate/EDG signaling by tumor necrosis factor-alpha in vascular endothelial cells. | 2002 | Thromb. Res. | pmid:12590954 |
Auge N et al. | Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12482824 |
Nava VE et al. | Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. | 2002 | Exp. Cell Res. | pmid:12441135 |
Benaud CM et al. | Deregulated activation of matriptase in breast cancer cells. | 2002 | Clin. Exp. Metastasis | pmid:12498394 |
Baumruker T and Prieschl EE | Sphingolipids and the regulation of the immune response. | 2002 | Semin. Immunol. | pmid:11884231 |
Weiner OD | Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. | 2002 | Curr. Opin. Cell Biol. | pmid:11891119 |
Meacci E et al. | Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors. | 2002 | Biochem. J. | pmid:11853542 |
Lee M and Han SS | Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras--phosphatidylinositol-3-kinase pathway. | 2002 | Cell. Signal. | pmid:11858945 |
English D | Do platelet-released phospholipids play a role in cardiovascular malformations and heritable coangulopathies? | 2002 | Teratology | pmid:11877771 |
Boguslawski G et al. | Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response. | 2002 | Exp. Cell Res. | pmid:11900487 |
Hanafusa N et al. | Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. | 2002 | Nephrol. Dial. Transplant. | pmid:11917049 |
Idzko M et al. | Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. | 2002 | FASEB J. | pmid:11919175 |
Mandala S et al. | Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. | 2002 | Science | pmid:11923495 |
Ancellin N et al. | Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. | 2002 | J. Biol. Chem. | pmid:11741921 |
Benaud C et al. | Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. | 2002 | J. Biol. Chem. | pmid:11792696 |
Birbes H et al. | Mitochondria and ceramide: intertwined roles in regulation of apoptosis. | 2002 | Adv. Enzyme Regul. | pmid:12123710 |
Johnson KR et al. | PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). | 2002 | J. Biol. Chem. | pmid:12124383 |
Thamilselvan V et al. | Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism. | 2002 | In Vitro Cell. Dev. Biol. Anim. | pmid:12197778 |
Coussin F et al. | Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction. | 2002 | Circ. Res. | pmid:12142348 |
Wang L et al. | Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells. | 2002 | Biochem. J. | pmid:12149127 |
Kveberg L et al. | Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases. | 2002 | Eur. J. Immunol. | pmid:12115604 |
Spiegel S and Kolesnick R | Sphingosine 1-phosphate as a therapeutic agent. | 2002 | Leukemia | pmid:12200669 |
Paris F et al. | Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. | 2002 | Nat. Med. | pmid:12205432 |
Davaille J et al. | Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts. | 2002 | J. Biol. Chem. | pmid:12138095 |
Okazaki T and Ito M | [Signal transduction of ceramide]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915339 |
Igarashi Y | [Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915345 |
Okajima F | [Distribution of sphingosine 1-phosphate in plasma lipoproteins and its role in the regulation of the vascular cell functions]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915346 |
Yatomi Y et al. | [Sphingosine 1-phosphate and vascular endothelial cells]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915347 |
Takuwa Y | [Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915348 |
Tsukahara T et al. | [Molecular diversity of sphingosine kinase]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915350 |
Rikitake Y et al. | Involvement of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:11788469 |
Graeler M et al. | Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate. | 2002 | J. Immunol. | pmid:12370333 |
Siehler S and Manning DR | Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069815 |
Takuwa Y | Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069818 |
Pyne S and Pyne NJ | Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069819 |
Okajima F | Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator? | 2002 | Biochim. Biophys. Acta | pmid:12069820 |
Meyer zu Heringdorf D et al. | Sphingosylphosphorylcholine-biological functions and mechanisms of action. | 2002 | Biochim. Biophys. Acta | pmid:12069827 |
Panetti TS | Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells. | 2002 | Biochim. Biophys. Acta | pmid:12069828 |
Siess W | Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate. | 2002 | Biochim. Biophys. Acta | pmid:12069830 |
Karliner JS | Lysophospholipids and the cardiovascular system. | 2002 | Biochim. Biophys. Acta | pmid:12069831 |
English D et al. | Lipid mediators of angiogenesis and the signalling pathways they initiate. | 2002 | Biochim. Biophys. Acta | pmid:12069833 |
Spiegel S et al. | Sphingosine 1-phosphate signaling: providing cells with a sense of direction. | 2002 | Trends Cell Biol. | pmid:12062172 |
Kohno T et al. | N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. | 2002 | FASEB J. | pmid:12087059 |
Wang S et al. | Two forms of membrane-bound sphingosine kinase in Tetrahymena and activity changes during growth and the cell cycle. | 2002 Jul-Aug | J. Eukaryot. Microbiol. | pmid:12188220 |
Young KW and Nahorski SR | Sphingosine 1-phosphate: a Ca2+ release mediator in the balance. | 2002 Nov-Dec | Cell Calcium | pmid:12543093 |
Dantas AP et al. | Sphingosine 1-phosphate and control of vascular tone. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12742827 |
Dziak R et al. | Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591009 |
Perry DK and Kolesnick RN | Ceramide and sphingosine 1-phosphate in anti-cancer therapies. | 2003 | Cancer Treat. Res. | pmid:12613204 |
Johnson KR et al. | Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. | 2003 | J. Biol. Chem. | pmid:12815058 |
Deroanne C et al. | EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. | 2003 | J. Cell. Sci. | pmid:12615978 |
Fueller M et al. | Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate. | 2003 | Cell. Signal. | pmid:12618211 |
Niedernberg A et al. | Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. | 2003 | Cell. Signal. | pmid:12618218 |
Honig SM et al. | FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. | 2003 | J. Clin. Invest. | pmid:12618517 |
Meyer zu Heringdorf D et al. | Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors. | 2003 | FEBS Lett. | pmid:14623109 |
Dolezalova H et al. | Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. | 2003 | J. Cell. Biochem. | pmid:12577307 |
Jeng YJ et al. | Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids. | 2003 | Endocrinology | pmid:12488330 |
Malchinkhuu E et al. | Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function. | 2003 | Biochem. J. | pmid:12470300 |
Rosenfeldt HM et al. | Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. | 2003 | FASEB J. | pmid:14519658 |
Kohno T et al. | Sphingosine 1-phosphate promotes cell migration through the activation of Cdc42 in Edg-6/S1P4-expressing cells. | 2003 | Genes Cells | pmid:12875654 |
Worrall D et al. | Sphingolipids, new players in plant signaling. | 2003 | Trends Plant Sci. | pmid:12878015 |
Deutschman DH et al. | Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate. | 2003 | Am. Heart J. | pmid:12851609 |
Burnett C and Howard K | Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo. | 2003 | EMBO Rep. | pmid:12856002 |
Laychock SG et al. | Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. | 2003 | Diabetes | pmid:12882914 |
Sauer B et al. | Antiapoptotic action of 1alpha,25-dihydroxyvitamin D3 in primary human melanocytes. | 2003 | Melanoma Res. | pmid:12883359 |
Pettus BJ et al. | The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. | 2003 | FASEB J. | pmid:12890694 |
Gratzinger D et al. | Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. | 2003 | FASEB J. | pmid:12890700 |
Muraki K and Imaizumi Y | A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. | 2003 | J. Pharmacol. Sci. | pmid:12890891 |
Annabi B et al. | Matrix metalloproteinase regulation of sphingosine-1-phosphate-induced angiogenic properties of bone marrow stromal cells. | 2003 | Exp. Hematol. | pmid:12842709 |
Kihara A et al. | Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. | 2003 | J. Biol. Chem. | pmid:12584204 |
Berg C et al. | Platelets induce reactive oxygen species-dependent growth of human skin fibroblasts. | 2003 | Eur. J. Cell Biol. | pmid:14703013 |
Bencini C et al. | Effects of sphingosine 1-phosphate on excitation-contraction coupling in mammalian skeletal muscle. | 2003 | J. Muscle Res. Cell. Motil. | pmid:14870969 |
Brailoiu E et al. | Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). | 2003 | Biochem. J. | pmid:12749764 |
Bernatchez PN et al. | Sphingosine 1-phosphate effect on endothelial cell PAF synthesis: role in cellular migration. | 2003 | J. Cell. Biochem. | pmid:14587028 |
Clair T et al. | Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. | 2003 | Cancer Res. | pmid:14500380 |
Dorsam G et al. | Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor. | 2003 | J. Immunol. | pmid:14500646 |
Facchinetti MM et al. | Differential branching of the sphingolipid metabolic pathways with the stage of development. Involvement of sphingosine kinase. | 2003 | Biol. Neonate | pmid:14504448 |
Clemens JJ et al. | Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14505636 |
Shikata Y et al. | Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT. | 2003 | FASEB J. | pmid:14656986 |
Niedernberg A et al. | Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. | 2003 | J Biomol Screen | pmid:14567777 |
Rao TS et al. | Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. | 2003 | Brain Res. | pmid:14568343 |
Sorensen SD et al. | Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. | 2003 | Mol. Pharmacol. | pmid:14573770 |
Spiegel S and Milstien S | Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways. | 2003 | Biochem. Soc. Trans. | pmid:14641029 |
Banno Y et al. | Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells. | 2003 | Biochem. J. | pmid:12385647 |
Högback S et al. | Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. | 2003 | Biochem. J. | pmid:12416995 |
Frohnert PW et al. | Lysophosphatidic acid promotes the proliferation of adult Schwann cells isolated from axotomized sciatic nerve. | 2003 | J. Neuropathol. Exp. Neurol. | pmid:12769191 |
Vogler R et al. | Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. | 2003 | J. Invest. Dermatol. | pmid:12648236 |
Bollag WB | Paradoxical effects of sphingosine-1-phosphate. | 2003 | J. Invest. Dermatol. | pmid:12648243 |
Uhlenbrock K et al. | Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. | 2003 | Cell. Physiol. Biochem. | pmid:12649592 |
Gómez-Muñoz A et al. | Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages. | 2003 | FEBS Lett. | pmid:12650926 |
Kimura T et al. | High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12775579 |
Duan HF et al. | [Progress in the study of physiological function of sphingosine 1-phosphate]. | 2003 | Sheng Li Ke Xue Jin Zhan | pmid:12778803 |
Salomone S et al. | S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate. | 2003 | Eur. J. Pharmacol. | pmid:12782194 |
Graeler MH et al. | Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes. | 2003 | J. Biol. Chem. | pmid:12782628 |
Van Brocklyn JR et al. | Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells. | 2003 | Cancer Lett. | pmid:12963123 |
Olivera A et al. | Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. | 2003 | J. Biol. Chem. | pmid:12963721 |
Rosen H and Liao J | Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. | 2003 | Curr Opin Chem Biol | pmid:12941420 |
Fegley AJ et al. | Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation. | 2003 | J. Surg. Res. | pmid:12943808 |
Lu X et al. | Total synthesis of two photoactivatable analogues of the growth-factor-like mediator sphingosine 1-phosphate: differential interaction with protein targets. | 2003 | J. Org. Chem. | pmid:12946147 |
zu Heringdorf DM et al. | Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1). | 2003 | Cell. Signal. | pmid:12742228 |