| MeSH term | MeSH ID | Detail |
|---|---|---|
| Peripheral Arterial Disease | D058729 | 7 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Morozov VI et al. | Sphingosine-1-phosphate: distribution, metabolism and role in the regulation of cellular functions. | 2013 Jan-Feb | Ukr Biokhim Zh (1999) | pmid:23534286 |
| Matheu MP et al. | Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. | 2013 | PLoS ONE | pmid:23533579 |
| Arce FT et al. | Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. | 2013 | Nanomedicine | pmid:23523769 |
| Wallington-Beddoe CT et al. | Oncogenic properties of sphingosine kinases in haematological malignancies. | 2013 | Br. J. Haematol. | pmid:23521541 |
| Yonesu K and Nara F | [Anti-angiogenic effect of bioactive lipid antagonists]. | 2012 | Nippon Rinsho | pmid:23513926 |
| Barth BM et al. | Gaucher's disease and cancer: a sphingolipid perspective. | 2013 | Crit Rev Oncog | pmid:23510065 |
| Bendall LJ and Basnett J | Role of sphingosine 1-phosphate in trafficking and mobilization of hematopoietic stem cells. | 2013 | Curr. Opin. Hematol. | pmid:23507960 |
| Loetscher E et al. | Assay to measure the secretion of sphingosine-1-phosphate from cells induced by S1P lyase inhibitors. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23499842 |
| Tran-Dinh A et al. | HDL and endothelial protection. | 2013 | Br. J. Pharmacol. | pmid:23488589 |
| Yang L et al. | Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis. | 2013 | J. Hepatol. | pmid:23466305 |
| Erkhembaatar LO et al. | Increased expression of sphingosine kinase in the amnion during labor. | 2013 | Placenta | pmid:23462226 |
| Natarajan V et al. | Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23449739 |
| Reichardt P et al. | A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes. | 2013 | EMBO J. | pmid:23443048 |
| Gaveglio VL et al. | Phosphatidic acid metabolism in rat liver cell nuclei. | 2013 | FEBS Lett. | pmid:23439070 |
| Kusch A et al. | Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury. | 2013 | Acta Physiol (Oxf) | pmid:23432924 |
| Kawahara S et al. | Sphingosine kinase 1 plays a role in the upregulation of CD44 expression through extracellular signal-regulated kinase signaling in human colon cancer cells. | 2013 | Anticancer Drugs | pmid:23426175 |
| Camacho L et al. | Acid ceramidase as a therapeutic target in metastatic prostate cancer. | 2013 | J. Lipid Res. | pmid:23423838 |
| Mudd JC et al. | Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes. | 2013 | Blood | pmid:23422746 |
| Ono Y et al. | Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration. | 2013 | Lipids Health Dis | pmid:23418753 |
| Dusaban SS et al. | Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23401561 |
| Southern C et al. | Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. | 2013 | J Biomol Screen | pmid:23396314 |
| CamprubÃ-Robles M et al. | Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor. | 2013 | J. Neurosci. | pmid:23392686 |
| Yangyuoru PM et al. | Fluorescent lipids as probes for sphingosine kinase activity by capillary electrophoresis. | 2013 | Methods Mol. Biol. | pmid:23386355 |
| Lee YJ et al. | Sphingosine-1-phosphate protects against bisphosphonate‑induced HUVEC cell death via regulation of c-Jun‑N‑terminal kinase signaling. | 2013 | Int. J. Mol. Med. | pmid:23381659 |
| Chang CH et al. | Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro. | 2013 | Acta Pharmacol. Sin. | pmid:23377549 |
| Salata D et al. | [Sphingosine-1-phosphate--molecular maestro]. | 2012 | Postepy Biochem. | pmid:23373414 |
| Finley A et al. | Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. | 2013 | PLoS ONE | pmid:23372844 |
| Babahosseini H et al. | Roles of bioactive sphingolipid metabolites in ovarian cancer cell biomechanics. | 2012 | Conf Proc IEEE Eng Med Biol Soc | pmid:23366417 |
| Tong X et al. | High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate. | 2013 | Cardiovasc Diabetol | pmid:23360427 |
| Dillahunt SE et al. | Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined. | 2013 | J. Immunol. | pmid:23359503 |
| Sharma N et al. | Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells. | 2013 | J. Leukoc. Biol. | pmid:23345392 |
| Cortez-Retamozo V et al. | Angiotensin II drives the production of tumor-promoting macrophages. | 2013 | Immunity | pmid:23333075 |
| Yasuo M et al. | Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate. | 2013 | PLoS ONE | pmid:23326540 |
| Lotinun S et al. | Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation. | 2013 | J. Clin. Invest. | pmid:23321671 |
| Tibolla G et al. | Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis. | 2013 | PLoS ONE | pmid:23320105 |
| Salvemini D et al. | Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain. | 2013 | Trends Pharmacol. Sci. | pmid:23318139 |
| Huang LS et al. | Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis. | 2013 | FASEB J. | pmid:23315259 |
| Watson DG et al. | The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. | 2013 | Cell. Signal. | pmid:23314175 |
| Kim YD et al. | Effects of sphingosine-1-phosphate on pacemaker activity of interstitial cells of Cajal from mouse small intestine. | 2013 | Mol. Cells | pmid:23307289 |
| Osawa Y et al. | Liver acid sphingomyelinase inhibits growth of metastatic colon cancer. | 2013 | J. Clin. Invest. | pmid:23298833 |
| Heffernan-Stroud LA and Obeid LM | Sphingosine kinase 1 in cancer. | 2013 | Adv. Cancer Res. | pmid:23290781 |
| Alshaker H et al. | Therapeutic potential of targeting SK1 in human cancers. | 2013 | Adv. Cancer Res. | pmid:23290780 |
| Cuvillier O et al. | Hypoxia, therapeutic resistance, and sphingosine 1-phosphate. | 2013 | Adv. Cancer Res. | pmid:23290779 |
| Karapetyan AV et al. | Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction. | 2013 | Stem Cells Dev. | pmid:23282236 |
| Liang J et al. | Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. | 2013 | Cancer Cell | pmid:23273921 |
| Kleinjan A et al. | Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model. | 2013 | Allergy | pmid:23253209 |
| Billich A et al. | Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors. | 2013 | Anal. Biochem. | pmid:23246729 |
| Evindar G et al. | Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23245510 |
| Xu Y et al. | Low sphingosine-1-phosphate impairs lung dendritic cells in cystic fibrosis. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23239501 |
| Park K et al. | A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. | 2013 | Mol. Cell. Biol. | pmid:23230267 |