MeSH term | MeSH ID | Detail |
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Peripheral Arterial Disease | D058729 | 7 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Li Y et al. | Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling. | 2004 | Exp. Cell Res. | pmid:15242766 |
Takeya H | ['Vegetable wasps and plant worms' and G-protein-coupled receptors]. | 2004 | J. UOEH | pmid:15244075 |
Maupas-Schwalm F et al. | The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator. | 2004 | FASEB J. | pmid:15231724 |
Fujita T et al. | Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1. | 2004 | Biochem. J. | pmid:15193146 |
Yue J et al. | Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level. | 2004 | Cell. Signal. | pmid:14687668 |
Harada J et al. | Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells. | 2004 | J. Neurochem. | pmid:14756825 |
Matloubian M et al. | Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. | 2004 | Nature | pmid:14737169 |
Monick MM et al. | Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:14742298 |
Kim DS et al. | Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. | 2004 | Cell. Signal. | pmid:14607279 |
Usui S et al. | Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. | 2004 | J. Biol. Chem. | pmid:14711826 |
Panetti TS et al. | Extracellular matrix molecules regulate endothelial cell migration stimulated by lysophosphatidic acid. | 2004 | J. Thromb. Haemost. | pmid:15333043 |
Kang YC et al. | Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation. | 2004 | Cell Death Differ. | pmid:15297884 |
Holdsworth G et al. | A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor. | 2004 | BMC Biochem. | pmid:15298705 |
Anliker B and Chun J | Cell surface receptors in lysophospholipid signaling. | 2004 | Semin. Cell Dev. Biol. | pmid:15271291 |
Pyne S et al. | Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases. | 2004 | Semin. Cell Dev. Biol. | pmid:15271294 |
Tokumura A | Metabolic pathways and physiological and pathological significances of lysolipid phosphate mediators. | 2004 | J. Cell. Biochem. | pmid:15258912 |
Muehlich S et al. | Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets. | 2004 | Atherosclerosis | pmid:15262182 |
Linz-McGillem LA et al. | Cytoskeletal rearrangement and caspase activation in sphingosine 1-phosphate-induced lung capillary tube formation. | 2004 | Stem Cells Dev. | pmid:15588507 |
Levkau B et al. | High-density lipoprotein stimulates myocardial perfusion in vivo. | 2004 | Circulation | pmid:15545521 |
Hale JJ et al. | A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. | 2004 | J. Med. Chem. | pmid:15615513 |
Lee C et al. | Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition. | 2004 | J Trauma | pmid:15580017 |
Tokuda H et al. | Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts. | 2004 | J. Cell. Biochem. | pmid:15034939 |
Goetzl EJ and Gräler MH | Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T lymphocytes. | 2004 | J. Leukoc. Biol. | pmid:14982946 |
Fukuda Y et al. | Identification of PECAM-1 association with sphingosine kinase 1 and its regulation by agonist-induced phosphorylation. | 2004 | Biochim. Biophys. Acta | pmid:14984734 |
Tanimoto T et al. | Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. | 2004 | Circ. Res. | pmid:15044318 |
Lockman K et al. | Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors. | 2004 | J. Biol. Chem. | pmid:15292266 |
Liu S et al. | Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase. | 2004 | J. Biol. Chem. | pmid:15466414 |
Birukov KG et al. | Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. | 2004 | Circ. Res. | pmid:15472119 |
Nosi D et al. | Effects of S1P on myoblastic cell contraction: possible involvement of Ca-independent mechanisms. | 2004 | Cells Tissues Organs (Print) | pmid:15655330 |
Xin C et al. | Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells. | 2004 | Br. J. Pharmacol. | pmid:15466446 |
Elices MJ | Editorial overview: Tie me up, tie me down: immunosuppressive therapies for the 21st century. | 2004 | Curr Opin Investig Drugs | pmid:15573862 |
Yu N et al. | Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes. | 2004 | Glia | pmid:14648542 |
Formigli L et al. | Sphingosine 1-phosphate induces cell contraction via calcium-independent/Rho-dependent pathways in undifferentiated skeletal muscle cells. | 2004 | J. Cell. Physiol. | pmid:14584038 |
Argraves KM et al. | Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis. | 2004 | J. Biol. Chem. | pmid:15377653 |
Grey A et al. | Osteoblastic cells express phospholipid receptors and phosphatases and proliferate in response to sphingosine-1-phosphate. | 2004 | Calcif. Tissue Int. | pmid:15354862 |
Clemens JJ et al. | Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15341948 |
Goetzl EJ et al. | Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system. | 2004 | J. Cell. Biochem. | pmid:15258896 |
Le Stunff H et al. | Generation and metabolism of bioactive sphingosine-1-phosphate. | 2004 | J. Cell. Biochem. | pmid:15258913 |
Duan HF et al. | Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. | 2004 | Exp. Cell Res. | pmid:15265705 |
Melendez AJ and Ibrahim FB | Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis. | 2004 | J. Immunol. | pmid:15265887 |
Ikeda H et al. | Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15240112 |
Misasi R et al. | Prosaposin: a new player in cell death prevention of U937 monocytic cells. | 2004 | Exp. Cell Res. | pmid:15242760 |
Bolz SS and Pohl U | Highly effective non-viral gene transfer into vascular smooth muscle cells of cultured resistance arteries demonstrated by genetic inhibition of sphingosine-1-phosphate-induced vasoconstriction. | 2003 Jul-Aug | J. Vasc. Res. | pmid:12913332 |
Cho H et al. | The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling. | 2003 | Biochem. J. | pmid:12564955 |
Jin Y et al. | Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. | 2003 | Blood | pmid:12586615 |
Dziak R et al. | Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591009 |
Perry DK and Kolesnick RN | Ceramide and sphingosine 1-phosphate in anti-cancer therapies. | 2003 | Cancer Treat. Res. | pmid:12613204 |
Deroanne C et al. | EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. | 2003 | J. Cell. Sci. | pmid:12615978 |
Fueller M et al. | Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate. | 2003 | Cell. Signal. | pmid:12618211 |
Niedernberg A et al. | Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. | 2003 | Cell. Signal. | pmid:12618218 |
Honig SM et al. | FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. | 2003 | J. Clin. Invest. | pmid:12618517 |
Meyer zu Heringdorf D et al. | Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors. | 2003 | FEBS Lett. | pmid:14623109 |
Dolezalova H et al. | Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. | 2003 | J. Cell. Biochem. | pmid:12577307 |
Jeng YJ et al. | Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids. | 2003 | Endocrinology | pmid:12488330 |
Rosenfeldt HM et al. | Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. | 2003 | FASEB J. | pmid:14519658 |
Meacci E et al. | Activation of phospholipase D by bradykinin and sphingosine 1-phosphate in A549 human lung adenocarcinoma cells via different GTP-binding proteins and protein kinase C delta signaling pathways. | 2003 | Biochemistry | pmid:12525155 |
Katsuma S et al. | Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12504122 |
Kim DS et al. | Sphingosine-1-phosphate promotes mouse melanocyte survival via ERK and Akt activation. | 2003 | Cell. Signal. | pmid:12873705 |
Kohno T et al. | Sphingosine 1-phosphate promotes cell migration through the activation of Cdc42 in Edg-6/S1P4-expressing cells. | 2003 | Genes Cells | pmid:12875654 |
Worrall D et al. | Sphingolipids, new players in plant signaling. | 2003 | Trends Plant Sci. | pmid:12878015 |
Deutschman DH et al. | Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate. | 2003 | Am. Heart J. | pmid:12851609 |
Burnett C and Howard K | Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo. | 2003 | EMBO Rep. | pmid:12856002 |
Laychock SG et al. | Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. | 2003 | Diabetes | pmid:12882914 |
Sauer B et al. | Antiapoptotic action of 1alpha,25-dihydroxyvitamin D3 in primary human melanocytes. | 2003 | Melanoma Res. | pmid:12883359 |
Pettus BJ et al. | The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. | 2003 | FASEB J. | pmid:12890694 |
Gratzinger D et al. | Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. | 2003 | FASEB J. | pmid:12890700 |
Muraki K and Imaizumi Y | A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. | 2003 | J. Pharmacol. Sci. | pmid:12890891 |
Annabi B et al. | Matrix metalloproteinase regulation of sphingosine-1-phosphate-induced angiogenic properties of bone marrow stromal cells. | 2003 | Exp. Hematol. | pmid:12842709 |
Kihara A et al. | Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. | 2003 | J. Biol. Chem. | pmid:12584204 |
Berg C et al. | Platelets induce reactive oxygen species-dependent growth of human skin fibroblasts. | 2003 | Eur. J. Cell Biol. | pmid:14703013 |
Bencini C et al. | Effects of sphingosine 1-phosphate on excitation-contraction coupling in mammalian skeletal muscle. | 2003 | J. Muscle Res. Cell. Motil. | pmid:14870969 |
Brailoiu E et al. | Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). | 2003 | Biochem. J. | pmid:12749764 |
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Buccoliero R and Futerman AH | The roles of ceramide and complex sphingolipids in neuronal cell function. | 2003 | Pharmacol. Res. | pmid:12676515 |
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Meacci E et al. | Down-regulation of EDG5/S1P2 during myogenic differentiation results in the specific uncoupling of sphingosine 1-phosphate signalling to phospholipase D. | 2003 | Biochim. Biophys. Acta | pmid:14499732 |
Clair T et al. | Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. | 2003 | Cancer Res. | pmid:14500380 |
Dorsam G et al. | Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor. | 2003 | J. Immunol. | pmid:14500646 |
Facchinetti MM et al. | Differential branching of the sphingolipid metabolic pathways with the stage of development. Involvement of sphingosine kinase. | 2003 | Biol. Neonate | pmid:14504448 |
Clemens JJ et al. | Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14505636 |
Shikata Y et al. | Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT. | 2003 | FASEB J. | pmid:14656986 |
Niedernberg A et al. | Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. | 2003 | J Biomol Screen | pmid:14567777 |
Banno Y et al. | Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells. | 2003 | Biochem. J. | pmid:12385647 |
Högback S et al. | Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. | 2003 | Biochem. J. | pmid:12416995 |
Kim JI et al. | Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells. | 2003 | J. Biol. Chem. | pmid:12796504 |
Thors B et al. | Inhibition of Akt phosphorylation by thrombin, histamine and lysophosphatidylcholine in endothelial cells. Differential role of protein kinase C. | 2003 | Atherosclerosis | pmid:12801607 |
Yamaguchi H et al. | Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells. | 2003 | Biochem. J. | pmid:12803545 |
Miura S et al. | Ras/Raf1-dependent signal in sphingosine-1-phosphate-induced tube formation in human coronary artery endothelial cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12821130 |
Vogler R et al. | Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. | 2003 | J. Invest. Dermatol. | pmid:12648236 |
Bollag WB | Paradoxical effects of sphingosine-1-phosphate. | 2003 | J. Invest. Dermatol. | pmid:12648243 |
Uhlenbrock K et al. | Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. | 2003 | Cell. Physiol. Biochem. | pmid:12649592 |
Gómez-Muñoz A et al. | Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages. | 2003 | FEBS Lett. | pmid:12650926 |
Kimura T et al. | High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12775579 |
Duan HF et al. | [Progress in the study of physiological function of sphingosine 1-phosphate]. | 2003 | Sheng Li Ke Xue Jin Zhan | pmid:12778803 |
Salomone S et al. | S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate. | 2003 | Eur. J. Pharmacol. | pmid:12782194 |
Graeler MH et al. | Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes. | 2003 | J. Biol. Chem. | pmid:12782628 |
Van Brocklyn JR et al. | Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells. | 2003 | Cancer Lett. | pmid:12963123 |
Olivera A et al. | Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. | 2003 | J. Biol. Chem. | pmid:12963721 |
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Fegley AJ et al. | Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation. | 2003 | J. Surg. Res. | pmid:12943808 |