MeSH term | MeSH ID | Detail |
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Peripheral Arterial Disease | D058729 | 7 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Japtok L et al. | Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2. | 2015 | FASEB J. | pmid:25911610 |
Stone ML et al. | Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25910934 |
Farnoud AM et al. | The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway. | 2015 | Infect. Immun. | pmid:25895971 |
Chimen M et al. | Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. | 2015 | Nat. Med. | pmid:25894827 |
Pulli I et al. | A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1-regulated Ca²⺠microdomain in the caveolar compartment. | 2015 | Biochim. Biophys. Acta | pmid:25892494 |
Urtz N et al. | Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo. | 2015 | Circ. Res. | pmid:26129975 |
Zankov DP and Ogita H | Actin-tethered junctional complexes in angiogenesis and lymphangiogenesis in association with vascular endothelial growth factor. | 2015 | Biomed Res Int | pmid:25883953 |
Desai P et al. | Dyslipidemia regulates thrombospondin-1-induced vascular smooth muscle cell chemotaxis. | 2015 | Mol. Cell. Biochem. | pmid:26350564 |
Moolenaar WH | Introduction to the ECR special issue on lysophospholipids in biology. | 2015 | Exp. Cell Res. | pmid:25746723 |
Newton J et al. | Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy. | 2015 | Exp. Cell Res. | pmid:25770011 |
Muñoz-Sáez E et al. | Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y). | 2015 | Neurosci. Lett. | pmid:25769802 |
Kang H et al. | The Therapeutic Effects of Human Mesenchymal Stem Cells Primed with Sphingosine-1 Phosphate on Pulmonary Artery Hypertension. | 2015 | Stem Cells Dev. | pmid:25761906 |
Carrera I et al. | A comparative evaluation of a novel vaccine in APP/PS1 mouse models of Alzheimer's disease. | 2015 | Biomed Res Int | pmid:25759822 |
Ueda N | Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate. | 2015 | Int J Mol Sci | pmid:25751724 |
Zhao S and Li J | Sphingosine-1-phosphate induces the migration of thyroid follicular carcinoma cells through the microRNA-17/PTK6/ERK1/2 pathway. | 2015 | PLoS ONE | pmid:25748447 |
Lin CC et al. | Sphingosine-1-phosphate mediates ICAM-1-dependent monocyte adhesion through p38 MAPK and p42/p44 MAPK-dependent Akt activation. | 2015 | PLoS ONE | pmid:25734900 |
Zhang DD et al. | Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors. | 2015 | Biol. Chem. | pmid:25720064 |
Schröder M et al. | Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. | 2015 | Biol. Chem. | pmid:25720062 |
Koch A et al. | Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration. | 2015 | Biol. Chem. | pmid:25719311 |
Baranowski M et al. | Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time- and intensity-dependent manner. | 2015 | Eur. J. Appl. Physiol. | pmid:25519954 |
Oskeritzian CA et al. | The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses. | 2015 | J. Allergy Clin. Immunol. | pmid:25512083 |
Kurano M et al. | LDL receptor and ApoE are involved in the clearance of ApoM-associated sphingosine 1-phosphate. | 2015 | J. Biol. Chem. | pmid:25505264 |
Roviezzo F et al. | S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms. | 2015 | Br. J. Pharmacol. | pmid:25439580 |
Konstantinou D et al. | Growth factors mediated differentiation of mesenchymal stem cells to cardiac polymicrotissue using hanging drop and bioreactor. | 2015 | Cell Biol. Int. | pmid:25492631 |
Pyne NJ and Kolesnick RN | The life and work of Dr. Robert Bittman (1942-2014). | 2015 | Biol. Chem. | pmid:25473803 |
Hashimoto Y et al. | Sphingosine-1-phosphate inhibits differentiation of C3H10T1/2 cells into adipocyte. | 2015 | Mol. Cell. Biochem. | pmid:25445169 |
Carroll B et al. | Sphingolipids in the DNA damage response. | 2015 | Adv Biol Regul | pmid:25434743 |
Benesch MG et al. | Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate. | 2015 | J. Lipid Res. | pmid:25896349 |
Klocke S et al. | Slow-freezing versus vitrification for human ovarian tissue cryopreservation. | 2015 | Arch. Gynecol. Obstet. | pmid:25115279 |
Wysoczynski M et al. | Identification of heme oxygenase 1 (HO-1) as a novel negative regulator of mobilization of hematopoietic stem/progenitor cells. | 2015 | Stem Cell Rev | pmid:25086571 |
Czubowicz K et al. | Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival. | 2015 | Mol. Neurobiol. | pmid:25056275 |
Burow P et al. | Activation of ATP secretion via volume-regulated anion channels by sphingosine-1-phosphate in RAW macrophages. | 2015 | Pflugers Arch. | pmid:24965069 |
Pan HY et al. | Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis. | 2015 | Int Endod J | pmid:24931601 |
Siow D et al. | Regulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1. | 2015 | Adv Biol Regul | pmid:25319495 |
Sano N et al. | New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury. | 2015 | World J. Gastroenterol. | pmid:26668502 |
Jones EE et al. | Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow. | 2015 | Bioanalysis | pmid:26505686 |
Ramos-Perez WD et al. | A map of the distribution of sphingosine 1-phosphate in the spleen. | 2015 | Nat. Immunol. | pmid:26502404 |
Winkler MS et al. | Decreased serum concentrations of sphingosine-1-phosphate in sepsis. | 2015 | Crit Care | pmid:26498205 |
Matula K et al. | Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer. | 2015 | BMC Cancer | pmid:26493335 |
Barnawi J et al. | Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). | 2015 | PLoS ONE | pmid:26485657 |
Moruno Manchon JF et al. | Cytoplasmic sphingosine-1-phosphate pathway modulates neuronal autophagy. | 2015 | Sci Rep | pmid:26477494 |
Deng Z et al. | Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis. | 2015 | Nat Commun | pmid:25907800 |
Wang K et al. | Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. | 2015 | PLoS Genet. | pmid:26474409 |
Jeong JK et al. | Modulation of the expression of sphingosine 1-phosphate 2 receptors regulates the differentiation of pre-adipocytes. | 2015 | Mol Med Rep | pmid:26459774 |
Sutter I et al. | Plasmalogens of high-density lipoproteins (HDL) are associated with coronary artery disease and anti-apoptotic activity of HDL. | 2015 | Atherosclerosis | pmid:26093887 |
Kihara Y et al. | Lysophospholipid receptors in drug discovery. | 2015 | Exp. Cell Res. | pmid:25499971 |
Boczkowska-Radziwon B et al. | Ozonation of human blood increases sphingosine-1-phosphate in plasma. | 2015 | J. Physiol. Pharmacol. | pmid:25903957 |
Le Bihan O et al. | Visualization of adherent cell monolayers by cryo-electron microscopy: A snapshot of endothelial adherens junctions. | 2015 | J. Struct. Biol. | pmid:26470813 |
Flávia Nardy A et al. | Modulation of Intrathymic Sphingosine-1-Phosphate Levels Promotes Escape of Immature Thymocytes to the Periphery with a Potential Proinflammatory Role in Chagas Disease. | 2015 | Biomed Res Int | pmid:26347020 |
Dai L et al. | Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression. | 2015 | Oncotarget | pmid:26327294 |
Simón MV et al. | Sphingosine-1-Phosphate Is a Crucial Signal for Migration of Retina Müller Glial Cells. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:26325420 |
Yang L et al. | Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice. | 2015 | Sci Rep | pmid:26324256 |
Brünnert D et al. | Sphingosine 1-phosphate regulates IL-8 expression and secretion via S1PR1 and S1PR2 receptors-mediated signaling in extravillous trophoblast derived HTR-8/SVneo cells. | 2015 | Placenta | pmid:26321412 |
Zhao YD et al. | A Biochemical Approach to Understand the Pathogenesis of Advanced Pulmonary Arterial Hypertension: Metabolomic Profiles of Arginine, Sphingosine-1-Phosphate, and Heme of Human Lung. | 2015 | PLoS ONE | pmid:26317340 |
Cantalupo A et al. | Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. | 2015 | Nat. Med. | pmid:26301690 |
Adamiak M et al. | Evidence for the involvement of sphingosine-1-phosphate in the homing and engraftment of hematopoietic stem cells to bone marrow. | 2015 | Oncotarget | pmid:26299919 |
Schaffert SA et al. | mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function. | 2015 | J. Immunol. | pmid:26163591 |
Gao Y et al. | Sphingosine kinase 1 as an anticancer therapeutic target. | 2015 | Drug Des Devel Ther | pmid:26150697 |
Denimal D et al. | Significant abnormalities of the HDL phosphosphingolipidome in type 1 diabetes despite normal HDL cholesterol concentration. | 2015 | Atherosclerosis | pmid:26142685 |
Yagi K et al. | Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage. | 2015 | Stroke | pmid:26138121 |
Nakagawa Y and Chiba K | Diversity and plasticity of microglial cells in psychiatric and neurological disorders. | 2015 | Pharmacol. Ther. | pmid:26129625 |
Jeong SK et al. | Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production. | 2015 | J. Dermatol. Sci. | pmid:26113114 |
Marycz K et al. | The effect of the bioactive sphingolipids S1P and C1P on multipotent stromal cells--new opportunities in regenerative medicine. | 2015 | Cell. Mol. Biol. Lett. | pmid:26110483 |
Chen MH et al. | Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. | 2015 | Oncotarget | pmid:26090720 |
Panneer Selvam S et al. | Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. | 2015 | Sci Signal | pmid:26082434 |
El-Najjar N et al. | Increased Levels of Sphingosylphosphorylcholine (SPC) in Plasma of Metabolic Syndrome Patients. | 2015 | PLoS ONE | pmid:26466367 |
Hyder CL et al. | Sphingolipids inhibit vimentin-dependent cell migration. | 2015 | J. Cell. Sci. | pmid:25908861 |
Ader I et al. | Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer. | 2015 | Oncotarget | pmid:25915662 |
Surya VN et al. | Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress. | 2016 | J R Soc Interface | pmid:27974574 |
Soltau I et al. | Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans. | 2016 | PLoS ONE | pmid:27973607 |
Chew WS et al. | To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling. | 2016 | Pharmacol. Res. | pmid:27663260 |
Moruno Manchon JF et al. | SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells. | 2016 | Autophagy | pmid:27467777 |
Nagahashi M et al. | The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases. | 2016 | J. Lipid Res. | pmid:27459945 |
Poissonnier A et al. | CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice. | 2016 | Immunity | pmid:27438772 |
Zhang Q et al. | Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text]. | 2016 | Am. J. Chin. Med. | pmid:27430910 |
Fleming JK et al. | A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay. | 2016 | J. Lipid Res. | pmid:27444045 |
Jin L et al. | The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined. | 2016 | World J Surg Oncol | pmid:27129720 |
Nagura Y et al. | Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction. | 2016 | Transfus Med | pmid:27350440 |
Sanchez T | Sphingosine-1-Phosphate Signaling in Endothelial Disorders. | 2016 | Curr Atheroscler Rep | pmid:27115142 |
Crespo I et al. | Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin. | 2016 | J. Pineal Res. | pmid:27101794 |
Riganti L et al. | Sphingosine-1-Phosphate (S1P) Impacts Presynaptic Functions by Regulating Synapsin I Localization in the Presynaptic Compartment. | 2016 | J. Neurosci. | pmid:27098703 |
Cai Y et al. | FOXF1 maintains endothelial barrier function and prevents edema after lung injury. | 2016 | Sci Signal | pmid:27095594 |
Castaldi A et al. | Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. | 2016 | Cell. Signal. | pmid:27094722 |
Trinh HK et al. | Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease. | 2016 | Sci Rep | pmid:27830727 |
Zhang H et al. | Binding Characteristics of Sphingosine-1-Phosphate to ApoM hints to Assisted Release Mechanism via the ApoM Calyx-Opening. | 2016 | Sci Rep | pmid:27476912 |
Luo B et al. | Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance. | 2016 | Immunity | pmid:26872696 |
Li J et al. | Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway. | 2016 | Tumour Biol. | pmid:26857281 |
Camaré C et al. | The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL. | 2016 | Free Radic. Biol. Med. | pmid:26855418 |
Kim SE et al. | The Role of Sphingosine-1-Phosphate in Adipogenesis of Graves' Orbitopathy. | 2016 | Invest. Ophthalmol. Vis. Sci. | pmid:26830367 |
Chen J et al. | Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. | 2016 | Biochim. Biophys. Acta | pmid:26615875 |
Maczis M et al. | Sphingosine-1-phosphate and estrogen signaling in breast cancer. | 2016 | Adv Biol Regul | pmid:26601898 |
Zhang F et al. | Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26589326 |
Gao D et al. | Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:26859520 |
Zeng Y et al. | Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop. | 2016 | Oncotarget | pmid:27556509 |
Nagahashi M et al. | Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods. | 2016 | J Mammary Gland Biol Neoplasia | pmid:27194029 |
Patmanathan SN et al. | Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. | 2016 | Sci Rep | pmid:27160553 |
Li N and Zhang F | Implication of sphingosin-1-phosphate in cardiovascular regulation. | 2016 | Front Biosci (Landmark Ed) | pmid:27100508 |
Serdar M et al. | Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia. | 2016 | Brain Behav. Immun. | pmid:26456693 |
Arish M et al. | Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases. | 2016 | Drug Discov. Today | pmid:26456576 |
Kurano M et al. | Resveratrol exerts a biphasic effect on apolipoprotein M. | 2016 | Br. J. Pharmacol. | pmid:26445217 |