MeSH term | MeSH ID | Detail |
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Acne Vulgaris | D000152 | 35 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Dantas AP et al. | Sphingosine 1-phosphate and control of vascular tone. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12742827 |
Itagaki K and Hauser CJ | Sphingosine 1-phosphate, a diffusible calcium influx factor mediating store-operated calcium entry. | 2003 | J. Biol. Chem. | pmid:12746430 |
Kim DS et al. | Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation. | 2003 | J. Cell. Sci. | pmid:12665551 |
Dziak R et al. | Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591009 |
Perry DK and Kolesnick RN | Ceramide and sphingosine 1-phosphate in anti-cancer therapies. | 2003 | Cancer Treat. Res. | pmid:12613204 |
Johnson KR et al. | Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. | 2003 | J. Biol. Chem. | pmid:12815058 |
Deroanne C et al. | EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. | 2003 | J. Cell. Sci. | pmid:12615978 |
Fueller M et al. | Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate. | 2003 | Cell. Signal. | pmid:12618211 |
Niedernberg A et al. | Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. | 2003 | Cell. Signal. | pmid:12618218 |
Honig SM et al. | FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. | 2003 | J. Clin. Invest. | pmid:12618517 |
Pacheco YM et al. | Sphingosine 1-phosphate signal survival and mitogenesis are mediated by lipid-stereospecific binding of triacylglycerol-rich lipoproteins. | 2003 | Cell. Mol. Life Sci. | pmid:14685698 |
Jeng YJ et al. | Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids. | 2003 | Endocrinology | pmid:12488330 |
Malchinkhuu E et al. | Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function. | 2003 | Biochem. J. | pmid:12470300 |
Rosenfeldt HM et al. | Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. | 2003 | FASEB J. | pmid:14519658 |
Worrall D et al. | Sphingolipids, new players in plant signaling. | 2003 | Trends Plant Sci. | pmid:12878015 |
Deutschman DH et al. | Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate. | 2003 | Am. Heart J. | pmid:12851609 |
Burnett C and Howard K | Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo. | 2003 | EMBO Rep. | pmid:12856002 |
Laychock SG et al. | Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. | 2003 | Diabetes | pmid:12882914 |
Sauer B et al. | Antiapoptotic action of 1alpha,25-dihydroxyvitamin D3 in primary human melanocytes. | 2003 | Melanoma Res. | pmid:12883359 |
Pettus BJ et al. | The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. | 2003 | FASEB J. | pmid:12890694 |
Gratzinger D et al. | Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. | 2003 | FASEB J. | pmid:12890700 |
Muraki K and Imaizumi Y | A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. | 2003 | J. Pharmacol. Sci. | pmid:12890891 |
Annabi B et al. | Matrix metalloproteinase regulation of sphingosine-1-phosphate-induced angiogenic properties of bone marrow stromal cells. | 2003 | Exp. Hematol. | pmid:12842709 |
Djanani A et al. | Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes. | 2003 | Regul. Pept. | pmid:12972327 |
Bencini C et al. | Effects of sphingosine 1-phosphate on excitation-contraction coupling in mammalian skeletal muscle. | 2003 | J. Muscle Res. Cell. Motil. | pmid:14870969 |
Clair T et al. | Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. | 2003 | Cancer Res. | pmid:14500380 |
Dorsam G et al. | Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor. | 2003 | J. Immunol. | pmid:14500646 |
Facchinetti MM et al. | Differential branching of the sphingolipid metabolic pathways with the stage of development. Involvement of sphingosine kinase. | 2003 | Biol. Neonate | pmid:14504448 |
Clemens JJ et al. | Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14505636 |
Shikata Y et al. | Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT. | 2003 | FASEB J. | pmid:14656986 |
Niedernberg A et al. | Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. | 2003 | J Biomol Screen | pmid:14567777 |
Rao TS et al. | Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. | 2003 | Brain Res. | pmid:14568343 |
Sorensen SD et al. | Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. | 2003 | Mol. Pharmacol. | pmid:14573770 |
Spiegel S and Milstien S | Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways. | 2003 | Biochem. Soc. Trans. | pmid:14641029 |
Ignatov A et al. | Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14592418 |
Kim DS et al. | Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis. | 2003 | Arch. Pharm. Res. | pmid:14560924 |
Banno Y et al. | Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells. | 2003 | Biochem. J. | pmid:12385647 |
Högback S et al. | Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. | 2003 | Biochem. J. | pmid:12416995 |
Frohnert PW et al. | Lysophosphatidic acid promotes the proliferation of adult Schwann cells isolated from axotomized sciatic nerve. | 2003 | J. Neuropathol. Exp. Neurol. | pmid:12769191 |
Hakogi T et al. | Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12639553 |
Bollag WB | Paradoxical effects of sphingosine-1-phosphate. | 2003 | J. Invest. Dermatol. | pmid:12648243 |
Uhlenbrock K et al. | Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. | 2003 | Cell. Physiol. Biochem. | pmid:12649592 |
Gómez-Muñoz A et al. | Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages. | 2003 | FEBS Lett. | pmid:12650926 |
Kimura T et al. | High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12775579 |
Duan HF et al. | [Progress in the study of physiological function of sphingosine 1-phosphate]. | 2003 | Sheng Li Ke Xue Jin Zhan | pmid:12778803 |
Salomone S et al. | S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate. | 2003 | Eur. J. Pharmacol. | pmid:12782194 |
Graeler MH et al. | Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes. | 2003 | J. Biol. Chem. | pmid:12782628 |
Van Brocklyn JR et al. | Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells. | 2003 | Cancer Lett. | pmid:12963123 |
Olivera A et al. | Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. | 2003 | J. Biol. Chem. | pmid:12963721 |
Rosen H and Liao J | Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. | 2003 | Curr Opin Chem Biol | pmid:12941420 |
Fegley AJ et al. | Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation. | 2003 | J. Surg. Res. | pmid:12943808 |
Lu X et al. | Total synthesis of two photoactivatable analogues of the growth-factor-like mediator sphingosine 1-phosphate: differential interaction with protein targets. | 2003 | J. Org. Chem. | pmid:12946147 |
zu Heringdorf DM et al. | Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1). | 2003 | Cell. Signal. | pmid:12742228 |
Bolz SS and Pohl U | Highly effective non-viral gene transfer into vascular smooth muscle cells of cultured resistance arteries demonstrated by genetic inhibition of sphingosine-1-phosphate-induced vasoconstriction. | 2003 Jul-Aug | J. Vasc. Res. | pmid:12913332 |
Li Y et al. | Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling. | 2004 | Exp. Cell Res. | pmid:15242766 |
Takeya H | ['Vegetable wasps and plant worms' and G-protein-coupled receptors]. | 2004 | J. UOEH | pmid:15244075 |
Maupas-Schwalm F et al. | The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator. | 2004 | FASEB J. | pmid:15231724 |
Fujita T et al. | Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1. | 2004 | Biochem. J. | pmid:15193146 |
Brinkmann V et al. | FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. | 2004 | Am. J. Transplant. | pmid:15196057 |
Im DS et al. | Enhancement of sphingosine 1-phosphate-induced phospholipase C activation during G(0)-G(1) transition in rat hepatocytes. | 2004 | J. Pharmacol. Sci. | pmid:15215654 |
Pandey S and Assmann SM | The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. | 2004 | Plant Cell | pmid:15155892 |
Barnes PJ | Ceramide lances the lungs. | 2004 | Nat. Med. | pmid:14760419 |
Yue J et al. | Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level. | 2004 | Cell. Signal. | pmid:14687668 |
Harada J et al. | Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells. | 2004 | J. Neurochem. | pmid:14756825 |
Matloubian M et al. | Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. | 2004 | Nature | pmid:14737169 |
Monick MM et al. | Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:14742298 |
Kim DS et al. | Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. | 2004 | Cell. Signal. | pmid:14607279 |
Usui S et al. | Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. | 2004 | J. Biol. Chem. | pmid:14711826 |
Gräler MH and Goetzl EJ | The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. | 2004 | FASEB J. | pmid:14715694 |
Ohmori T et al. | Platelet-derived sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. | 2004 | J. Thromb. Haemost. | pmid:14717991 |
Renkl A et al. | Distinct effects of sphingosine-1-phosphate, lysophosphatidic acid and histamine in human and mouse dendritic cells. | 2004 | Int. J. Mol. Med. | pmid:14719124 |
Shimamura K et al. | Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells. | 2004 | Eur. J. Pharmacol. | pmid:14975703 |
Linz-McGillem LA et al. | Cytoskeletal rearrangement and caspase activation in sphingosine 1-phosphate-induced lung capillary tube formation. | 2004 | Stem Cells Dev. | pmid:15588507 |
Levkau B et al. | High-density lipoprotein stimulates myocardial perfusion in vivo. | 2004 | Circulation | pmid:15545521 |
Hale JJ et al. | A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. | 2004 | J. Med. Chem. | pmid:15615513 |
Lee C et al. | Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition. | 2004 | J Trauma | pmid:15580017 |
Yatomi Y et al. | Sphingosine 1-phosphate breakdown in platelets. | 2004 | J. Biochem. | pmid:15625319 |
Ochi S et al. | Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes. | 2004 | J. Biol. Chem. | pmid:14702348 |
Goetzl EJ and Gräler MH | Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T lymphocytes. | 2004 | J. Leukoc. Biol. | pmid:14982946 |
Fukuda Y et al. | Identification of PECAM-1 association with sphingosine kinase 1 and its regulation by agonist-induced phosphorylation. | 2004 | Biochim. Biophys. Acta | pmid:14984734 |
Tanimoto T et al. | Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. | 2004 | Circ. Res. | pmid:15044318 |
Lockman K et al. | Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors. | 2004 | J. Biol. Chem. | pmid:15292266 |
Nosi D et al. | Effects of S1P on myoblastic cell contraction: possible involvement of Ca-independent mechanisms. | 2004 | Cells Tissues Organs (Print) | pmid:15655330 |
Ozbay T et al. | ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism. | 2004 | Endocr. Res. | pmid:15666826 |
Elices MJ | Editorial overview: Tie me up, tie me down: immunosuppressive therapies for the 21st century. | 2004 | Curr Opin Investig Drugs | pmid:15573862 |
Yu N et al. | Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes. | 2004 | Glia | pmid:14648542 |
Formigli L et al. | Sphingosine 1-phosphate induces cell contraction via calcium-independent/Rho-dependent pathways in undifferentiated skeletal muscle cells. | 2004 | J. Cell. Physiol. | pmid:14584038 |
Argraves KM et al. | Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis. | 2004 | J. Biol. Chem. | pmid:15377653 |
Grey A et al. | Osteoblastic cells express phospholipid receptors and phosphatases and proliferate in response to sphingosine-1-phosphate. | 2004 | Calcif. Tissue Int. | pmid:15354862 |
Clemens JJ et al. | Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15341948 |
Gonzalez E et al. | Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. | 2004 | J. Biol. Chem. | pmid:15292187 |
Lee H et al. | Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15294853 |
Roth Z and Hansen PJ | Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. | 2004 | Biol. Reprod. | pmid:15317688 |
Hemmings DG et al. | Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats. | 2004 | Br. J. Pharmacol. | pmid:15326035 |
Goetzl EJ et al. | Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system. | 2004 | J. Cell. Biochem. | pmid:15258896 |
Le Stunff H et al. | Generation and metabolism of bioactive sphingosine-1-phosphate. | 2004 | J. Cell. Biochem. | pmid:15258913 |
Duan HF et al. | Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. | 2004 | Exp. Cell Res. | pmid:15265705 |
Melendez AJ and Ibrahim FB | Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis. | 2004 | J. Immunol. | pmid:15265887 |
Ikeda H et al. | Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15240112 |
Misasi R et al. | Prosaposin: a new player in cell death prevention of U937 monocytic cells. | 2004 | Exp. Cell Res. | pmid:15242760 |