MeSH term | MeSH ID | Detail |
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Farber Lipogranulomatosis | D055577 | 1 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cuvillier O | Sphingosine in apoptosis signaling. | 2002 | Biochim. Biophys. Acta | pmid:12531549 |
Tanski W et al. | Sphingosine-1-phosphate induces G(alphai)-coupled, PI3K/ras-dependent smooth muscle cell migration. | 2002 | J. Surg. Res. | pmid:12443721 |
Osada M et al. | Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12445827 |
Grey A et al. | The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase. | 2002 | Endocrinology | pmid:12446603 |
Auge N et al. | Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12482824 |
Nava VE et al. | Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. | 2002 | Exp. Cell Res. | pmid:12441135 |
Benaud CM et al. | Deregulated activation of matriptase in breast cancer cells. | 2002 | Clin. Exp. Metastasis | pmid:12498394 |
Maceyka M et al. | Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. | 2002 | Biochim. Biophys. Acta | pmid:12531554 |
Idzko M et al. | Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. | 2002 | FASEB J. | pmid:11919175 |
Mandala S et al. | Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. | 2002 | Science | pmid:11923495 |
Ancellin N et al. | Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. | 2002 | J. Biol. Chem. | pmid:11741921 |
Benaud C et al. | Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. | 2002 | J. Biol. Chem. | pmid:11792696 |
Wang J et al. | Receptor-mediated activation of a Cl(-) current by LPA and S1P in cultured corneal keratocytes. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12356825 |
Van Brocklyn J et al. | Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. | 2002 | Cancer Lett. | pmid:12175535 |
Birbes H et al. | Mitochondria and ceramide: intertwined roles in regulation of apoptosis. | 2002 | Adv. Enzyme Regul. | pmid:12123710 |
Johnson KR et al. | PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). | 2002 | J. Biol. Chem. | pmid:12124383 |
Thamilselvan V et al. | Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism. | 2002 | In Vitro Cell. Dev. Biol. Anim. | pmid:12197778 |
Coussin F et al. | Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction. | 2002 | Circ. Res. | pmid:12142348 |
Wang L et al. | Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells. | 2002 | Biochem. J. | pmid:12149127 |
Kveberg L et al. | Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases. | 2002 | Eur. J. Immunol. | pmid:12115604 |
Spiegel S and Kolesnick R | Sphingosine 1-phosphate as a therapeutic agent. | 2002 | Leukemia | pmid:12200669 |
Kihara A and Igarashi Y | [Sphingosine 1-phosphate in yeast]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915338 |
Okazaki T and Ito M | [Signal transduction of ceramide]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915339 |
Igarashi Y | [Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915345 |
Okajima F | [Distribution of sphingosine 1-phosphate in plasma lipoproteins and its role in the regulation of the vascular cell functions]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915346 |
Yatomi Y et al. | [Sphingosine 1-phosphate and vascular endothelial cells]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915347 |
Takuwa Y | [Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915348 |
Tsukahara T et al. | [Molecular diversity of sphingosine kinase]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915350 |
Rikitake Y et al. | Involvement of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:11788469 |
Graeler M et al. | Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate. | 2002 | J. Immunol. | pmid:12370333 |
Takuwa Y et al. | The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities. | 2002 | J. Biochem. | pmid:12038970 |
Meacci E et al. | A role for calcium in sphingosine 1-phosphate-induced phospholipase D activity in C2C12 myoblasts. | 2002 | FEBS Lett. | pmid:12067705 |
Le Stunff H et al. | Sphingosine-1-phosphate and lipid phosphohydrolases. | 2002 | Biochim. Biophys. Acta | pmid:12069805 |
Kluk MJ and Hla T | Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069812 |
Siehler S and Manning DR | Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069815 |
Takuwa Y | Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069818 |
Pyne S and Pyne NJ | Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069819 |
Okajima F | Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator? | 2002 | Biochim. Biophys. Acta | pmid:12069820 |
Meyer zu Heringdorf D et al. | Sphingosylphosphorylcholine-biological functions and mechanisms of action. | 2002 | Biochim. Biophys. Acta | pmid:12069827 |
Panetti TS | Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells. | 2002 | Biochim. Biophys. Acta | pmid:12069828 |
Siess W | Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate. | 2002 | Biochim. Biophys. Acta | pmid:12069830 |
Karliner JS | Lysophospholipids and the cardiovascular system. | 2002 | Biochim. Biophys. Acta | pmid:12069831 |
English D et al. | Lipid mediators of angiogenesis and the signalling pathways they initiate. | 2002 | Biochim. Biophys. Acta | pmid:12069833 |
Baudhuin LM et al. | Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific. | 2002 | Mol. Pharmacol. | pmid:12181443 |
Wang S et al. | Two forms of membrane-bound sphingosine kinase in Tetrahymena and activity changes during growth and the cell cycle. | 2002 Jul-Aug | J. Eukaryot. Microbiol. | pmid:12188220 |
Young KW and Nahorski SR | Sphingosine 1-phosphate: a Ca2+ release mediator in the balance. | 2002 Nov-Dec | Cell Calcium | pmid:12543093 |
Jin Y et al. | Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. | 2003 | Blood | pmid:12586615 |
Katsuma S et al. | Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12504122 |
Buccoliero R and Futerman AH | The roles of ceramide and complex sphingolipids in neuronal cell function. | 2003 | Pharmacol. Res. | pmid:12676515 |
Yamaguchi H et al. | Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells. | 2003 | Biochem. J. | pmid:12803545 |