MeSH term | MeSH ID | Detail |
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Farber Lipogranulomatosis | D055577 | 1 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Pilorget A et al. | Inhibition of angiogenic properties of brain endothelial cells by platelet-derived sphingosine-1-phosphate. | 2005 | J. Cereb. Blood Flow Metab. | pmid:15829917 |
Cartwright TA et al. | Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers. | 2013 | J. Cereb. Blood Flow Metab. | pmid:23168528 |
Wirrig C et al. | Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries. | 2011 | J. Cereb. Blood Flow Metab. | pmid:20551970 |
He X et al. | Quantitative analysis of sphingosine-1-phosphate by HPLC after napthalene-2,3-dicarboxaldehyde (NDA) derivatization. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19285924 |
Butter JJ et al. | A rapid and validated HPLC method to quantify sphingosine 1-phosphate in human plasma using solid-phase extraction followed by derivatization with fluorescence detection. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16023899 |
Gao D et al. | Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:26859520 |
Lan T et al. | Simultaneous determination of sphingosine and sphingosine 1-phosphate in biological samples by liquid chromatography-tandem mass spectrometry. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21292568 |
Suomalainen L et al. | Sphingosine-1-phosphate in inhibition of male germ cell apoptosis in the human testis. | 2003 | J. Clin. Endocrinol. Metab. | pmid:14602806 |
Lee SH et al. | Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humans. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22679064 |
Kim BJ et al. | Plasma sphingosine 1-phosphate levels and the risk of vertebral fracture in postmenopausal women. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22879631 |
Watson L et al. | Increased serum concentration of sphingosine-1-phosphate in juvenile-onset systemic lupus erythematosus. | 2012 | J. Clin. Immunol. | pmid:22648459 |
Goetzl EJ et al. | Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia. | 2011 | J. Clin. Immunol. | pmid:21671128 |
Proia RL and Hla T | Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. | 2015 | J. Clin. Invest. | pmid:25831442 |
Honig SM et al. | FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. | 2003 | J. Clin. Invest. | pmid:12618517 |
Zhang Y et al. | Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. | 2014 | J. Clin. Invest. | pmid:24837436 |
Degagné E et al. | Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. | 2014 | J. Clin. Invest. | pmid:25347472 |
Kono M et al. | Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. | 2014 | J. Clin. Invest. | pmid:24667638 |
Xiong Y et al. | Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. | 2014 | J. Clin. Invest. | pmid:25250575 |
Fukuhara S et al. | The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. | 2012 | J. Clin. Invest. | pmid:22406534 |
Sato TN | A new role of lipid receptors in vascular and cardiac morphogenesis. | 2000 | J. Clin. Invest. | pmid:11032853 |
Garcia JG et al. | Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. | 2001 | J. Clin. Invest. | pmid:11544274 |
Liu Y et al. | Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. | 2000 | J. Clin. Invest. | pmid:11032855 |
Oo ML et al. | Engagement of S1Pâ‚-degradative mechanisms leads to vascular leak in mice. | 2011 | J. Clin. Invest. | pmid:21555855 |
Osawa Y et al. | Liver acid sphingomyelinase inhibits growth of metastatic colon cancer. | 2013 | J. Clin. Invest. | pmid:23298833 |
Wang F et al. | Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice. | 2010 | J. Clin. Invest. | pmid:20978351 |
Camerer E et al. | Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. | 2009 | J. Clin. Invest. | pmid:19603543 |
Cao C et al. | The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. | 2010 | J. Clin. Invest. | pmid:20458145 |
Lotinun S et al. | Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation. | 2013 | J. Clin. Invest. | pmid:23321671 |
Idzko M et al. | Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. | 2006 | J. Clin. Invest. | pmid:17080194 |
Aarthi JJ et al. | Dissecting the role of the S1P/S1PR axis in health and disease. | 2011 | J. Dent. Res. | pmid:21248363 |
Seo J et al. | Sphingosine-1-phosphate signaling in human submandibular cells. | 2010 | J. Dent. Res. | pmid:20651091 |
Youm JK et al. | K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling. | 2008 | J. Dermatol. Sci. | pmid:18420384 |
Bock S et al. | Sphingosine 1-phospate differentially modulates maturation and function of human Langerhans-like cells. | 2016 | J. Dermatol. Sci. | pmid:26803226 |
Schaper K et al. | Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis. | 2013 | J. Dermatol. Sci. | pmid:23643308 |
Kawanabe T et al. | Sphingosine 1-phosphate accelerates wound healing in diabetic mice. | 2007 | J. Dermatol. Sci. | pmid:17643267 |
Jeong SK et al. | Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production. | 2015 | J. Dermatol. Sci. | pmid:26113114 |
Werth S et al. | Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. | 2017 | J. Endocrinol. | pmid:28970286 |
Kim BJ et al. | The effect of sphingosine-1-phosphate on bone metabolism in humans depends on its plasma/bone marrow gradient. | 2016 | J. Endocrinol. Invest. | pmid:26219613 |
Wang S et al. | Two forms of membrane-bound sphingosine kinase in Tetrahymena and activity changes during growth and the cell cycle. | 2002 Jul-Aug | J. Eukaryot. Microbiol. | pmid:12188220 |
Kunisawa J et al. | Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. | 2007 | J. Exp. Med. | pmid:17875673 |
Pham TH et al. | Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. | 2010 | J. Exp. Med. | pmid:20026661 |
Jolly PS et al. | Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. | 2004 | J. Exp. Med. | pmid:15067032 |
Zamora-Pineda J et al. | Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress. | 2016 | J. Exp. Med. | pmid:27810923 |
Kabashima K et al. | Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. | 2006 | J. Exp. Med. | pmid:17101733 |
Willinger T et al. | Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling. | 2014 | J. Exp. Med. | pmid:24638168 |
Prieschl EE et al. | The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering. | 1999 | J. Exp. Med. | pmid:10429665 |
Ishii M et al. | Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. | 2010 | J. Exp. Med. | pmid:21135136 |
Bréart B et al. | Lipid phosphate phosphatase 3 enables efficient thymic egress. | 2011 | J. Exp. Med. | pmid:21576386 |
Zhang L et al. | A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. | 2012 | J. Exp. Med. | pmid:23148237 |
Jenne CN et al. | T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. | 2009 | J. Exp. Med. | pmid:19808259 |
Hla T et al. | S1P and the birth of platelets. | 2012 | J. Exp. Med. | pmid:23166370 |
Nombela-Arrieta C et al. | A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. | 2007 | J. Exp. Med. | pmid:17325199 |
Thangada S et al. | Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. | 2010 | J. Exp. Med. | pmid:20584883 |
Sar JI et al. | Sphingosine-1-phosphate stimulated connective tissue growth factor expression in human buccal fibroblasts: Inhibition by epigallocatechin-3-gallate. | 2015 | J. Formos. Med. Assoc. | pmid:24035571 |
Lamichhane A et al. | Nutritional components regulate the gut immune system and its association with intestinal immune disease development. | 2013 | J. Gastroenterol. Hepatol. | pmid:24251698 |
Lukowski ZL et al. | Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (Sonepcizumab) in a rabbit model. | 2013 | J. Glaucoma | pmid:21946553 |
English D et al. | Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer barrier function by lysophosphatidic acid, potential mediators of hematopoietic angiogenesis. | 1999 | J. Hematother. Stem Cell Res. | pmid:10645770 |
Shi Y et al. | Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. | 2012 | J. Hepatol. | pmid:21756852 |
Li C et al. | Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. | 2011 | J. Hepatol. | pmid:21145832 |
Yang L et al. | Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis. | 2013 | J. Hepatol. | pmid:23466305 |
Li C et al. | Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis. | 2009 | J. Hepatol. | pmid:19398237 |
Nojima H et al. | Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. | 2016 | J. Hepatol. | pmid:26254847 |
Osawa Y et al. | TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. | 2001 | J. Immunol. | pmid:11418646 |
Kimura T et al. | Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. | 2008 | J. Immunol. | pmid:18981156 |
Józefowski S et al. | Ceramide and ceramide 1-phosphate are negative regulators of TNF-α production induced by lipopolysaccharide. | 2010 | J. Immunol. | pmid:21041721 |
Gorlino CV et al. | Neutrophils exhibit differential requirements for homing molecules in their lymphatic and blood trafficking into draining lymph nodes. | 2014 | J. Immunol. | pmid:25015824 |
Till KJ et al. | Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukemia cells. | 2015 | J. Immunol. | pmid:25632006 |
Hwang IY et al. | An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and trafficking. | 2015 | J. Immunol. | pmid:25617475 |
Gohda M et al. | Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. | 2008 | J. Immunol. | pmid:18390715 |
Morillon YM et al. | Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration. | 2016 | J. Immunol. | pmid:27694496 |
Nijnik A et al. | The role of sphingosine-1-phosphate transporter Spns2 in immune system function. | 2012 | J. Immunol. | pmid:22664872 |
Fujii Y et al. | Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities. | 2012 | J. Immunol. | pmid:22131329 |
Goetzl EJ et al. | Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax. | 1999 | J. Immunol. | pmid:9973477 |
Bansal G et al. | RGS13 controls g protein-coupled receptor-evoked responses of human mast cells. | 2008 | J. Immunol. | pmid:19017978 |
Florey O and Haskard DO | Sphingosine 1-phosphate enhances Fc gamma receptor-mediated neutrophil activation and recruitment under flow conditions. | 2009 | J. Immunol. | pmid:19620297 |
Maeda Y et al. | Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3. | 2007 | J. Immunol. | pmid:17339438 |
Ocaña-Morgner C et al. | Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA. | 2011 | J. Immunol. | pmid:21421853 |
Dillmann C et al. | S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells. | 2016 | J. Immunol. | pmid:26783340 |
Yopp AC et al. | Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells. | 2005 | J. Immunol. | pmid:16116177 |
Czeloth N et al. | Sphingosine-1-phosphate mediates migration of mature dendritic cells. | 2005 | J. Immunol. | pmid:16116182 |
Sensken SC et al. | Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia. | 2010 | J. Immunol. | pmid:20220090 |
Borge M et al. | The expression of sphingosine-1 phosphate receptor-1 in chronic lymphocytic leukemia cells is impaired by tumor microenvironmental signals and enhanced by piceatannol and R406. | 2014 | J. Immunol. | pmid:25127862 |
Dillahunt SE et al. | Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined. | 2013 | J. Immunol. | pmid:23359503 |
Huang MC et al. | Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice. | 2007 | J. Immunol. | pmid:17513728 |
Liao JJ et al. | Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate. | 2007 | J. Immunol. | pmid:17442922 |
Sensken SC et al. | Local inactivation of sphingosine 1-phosphate in lymph nodes induces lymphopenia. | 2011 | J. Immunol. | pmid:21289303 |
Samy ET et al. | Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate. | 2007 | J. Immunol. | pmid:17947634 |
Czeloth N et al. | Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen. | 2007 | J. Immunol. | pmid:17947659 |
Graeler M et al. | Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate. | 2002 | J. Immunol. | pmid:12370333 |
Radeke HH et al. | Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52. | 2005 | J. Immunol. | pmid:15728487 |
Kurashima Y et al. | Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy. | 2007 | J. Immunol. | pmid:17641024 |
Baker DA et al. | Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis. | 2010 | J. Immunol. | pmid:20644167 |
Vijayan M et al. | Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. | 2017 | J. Immunol. | pmid:28600291 |
Schaffert SA et al. | mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function. | 2015 | J. Immunol. | pmid:26163591 |
Malik ZA et al. | Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase. | 2003 | J. Immunol. | pmid:12626530 |
Johann AM et al. | Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression. | 2008 | J. Immunol. | pmid:18178864 |
Miller M et al. | Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate. | 2017 | J. Immunol. | pmid:28275141 |
Eskan MA et al. | Sphingosine 1-phosphate 1 and TLR4 mediate IFN-beta expression in human gingival epithelial cells. | 2008 | J. Immunol. | pmid:18209079 |
Sekiguchi M et al. | Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome. | 2008 | J. Immunol. | pmid:18209090 |
Melendez AJ and Ibrahim FB | Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis. | 2004 | J. Immunol. | pmid:15265887 |