| MeSH term | MeSH ID | Detail |
|---|---|---|
| Farber Lipogranulomatosis | D055577 | 1 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Watson DG et al. | The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. | 2013 | Cell. Signal. | pmid:23314175 |
| Kawahara S et al. | Sphingosine kinase 1 plays a role in the upregulation of CD44 expression through extracellular signal-regulated kinase signaling in human colon cancer cells. | 2013 | Anticancer Drugs | pmid:23426175 |
| Starzyńska T et al. | An intensified systemic trafficking of bone marrow-derived stem/progenitor cells in patients with pancreatic cancer. | 2013 | J. Cell. Mol. Med. | pmid:23672538 |
| Pantoja M et al. | Genetic elevation of sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila. | 2013 | Development | pmid:23154413 |
| Vessey DA et al. | FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning. | 2013 | Med Sci Monit Basic Res | pmid:23567658 |
| Takuwa Y et al. | Sphingosine-1-phosphate signaling in physiology and diseases. | 2012 Sep-Oct | Biofactors | pmid:22674845 |
| Iwaki S et al. | Posttranscriptional regulation of expression of plasminogen activator inhibitor type-1 by sphingosine 1-phosphate in HepG2 liver cells. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22819712 |
| Fournie P et al. | Sphingosine-1 phosphate prevents ethanol-induced corneal epithelial apoptosis. | 2012 Mar-Apr | Indian J Ophthalmol | pmid:22446906 |
| Tse KW et al. | Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells. | 2012 Jan-Feb | Cell. Immunol. | pmid:22507871 |
| Yu FX et al. | Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. | 2012 | Cell | pmid:22863277 |
| He S et al. | Self-amplification mechanisms of mast cell activation: a new look in allergy. | 2012 | Curr. Mol. Med. | pmid:22920722 |
| Hisano Y et al. | The functional roles of S1P in immunity. | 2012 | J. Biochem. | pmid:22923732 |
| Aoyagi T et al. | The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis. | 2012 | Lymphat Res Biol | pmid:22984905 |
| Koch A et al. | Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells. | 2012 | Br. J. Pharmacol. | pmid:22221312 |
| Upadhyaya P et al. | The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22727907 |
| Zhang BL et al. | Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors. | 2012 | J Zhejiang Univ Sci B | pmid:22761247 |
| Kotelevets N et al. | Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis. | 2012 | PLoS ONE | pmid:22761740 |
| Nakahara T et al. | Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway. | 2012 | Fertil. Steril. | pmid:22763095 |
| Nijnik A et al. | The role of sphingosine-1-phosphate transporter Spns2 in immune system function. | 2012 | J. Immunol. | pmid:22664872 |
| Raje MR et al. | Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. | 2012 | Bioorg. Med. Chem. | pmid:22137932 |
| Lu H et al. | Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats. | 2012 | Mol. Cell. Biochem. | pmid:22139303 |
| Fujii Y et al. | Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities. | 2012 | J. Immunol. | pmid:22131329 |
| Ishimaru N et al. | CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy. | 2012 | Am. J. Pathol. | pmid:22067914 |
| Sato C et al. | Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22659743 |
| Farahat WA et al. | Ensemble analysis of angiogenic growth in three-dimensional microfluidic cell cultures. | 2012 | PLoS ONE | pmid:22662145 |
| Somers SJ et al. | Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection. | 2012 | Cardiovasc Drugs Ther | pmid:22392184 |
| Chakraborty G et al. | Ethanol triggers sphingosine 1-phosphate elevation along with neuroapoptosis in the developing mouse brain. | 2012 | J. Neurochem. | pmid:22393932 |
| Schnute ME et al. | Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. | 2012 | Biochem. J. | pmid:22397330 |
| Bachmaier K et al. | Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin. | 2012 | PLoS ONE | pmid:22355325 |
| Duru EA et al. | SRC regulates sphingosine-1-phosphate mediated smooth muscle cell migration. | 2012 | J. Surg. Res. | pmid:21920544 |
| Belvitch P and Dudek SM | Role of FAK in S1P-regulated endothelial permeability. | 2012 | Microvasc. Res. | pmid:21925517 |
| Adamson RH et al. | Attenuation by sphingosine-1-phosphate of rat microvessel acute permeability response to bradykinin is rapidly reversible. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22427519 |
| Wilkerson BA et al. | Sphingosine 1-phosphate (S1P) carrier-dependent regulation of endothelial barrier: high density lipoprotein (HDL)-S1P prolongs endothelial barrier enhancement as compared with albumin-S1P via effects on levels, trafficking, and signaling of S1P1. | 2012 | J. Biol. Chem. | pmid:23135269 |
| Tar L and Vécsei L | [Fingolimod therapy in multiple sclerosis--the issue of the pathomechanism]. | 2012 | Ideggyogy Sz | pmid:23136726 |
| Hla T et al. | S1P and the birth of platelets. | 2012 | J. Exp. Med. | pmid:23166370 |
| Bode C and Gräler MH | Quantification of sphingosine-1-phosphate and related sphingolipids by liquid chromatography coupled to tandem mass spectrometry. | 2012 | Methods Mol. Biol. | pmid:22528437 |
| Morishige J et al. | A cleanup method for mass spectrometry of sphingosine-1-phosphate in blood and solid tissues using a phosphate capture molecule. | 2012 | Methods Mol. Biol. | pmid:22528438 |
| Visentin B et al. | Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples. | 2012 | Methods Mol. Biol. | pmid:22528439 |
| Obinata H and Hla T | Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation. | 2012 | Methods Mol. Biol. | pmid:22528440 |
| Medlin MD et al. | Quantifying sphingosine-1-phosphate-dependent activation of the RhoGTPases. | 2012 | Methods Mol. Biol. | pmid:22528442 |
| Belmonte SA and Suhaiman L | Optimized protocols to analyze sphingosine-1-phosphate signal transduction pathways during acrosomal exocytosis in human sperm. | 2012 | Methods Mol. Biol. | pmid:22528443 |
| Ishii T et al. | Use of intravital microscopy and in vitro chemotaxis assays to study the roles of sphingosine-1-phosphate in bone homeostasis. | 2012 | Methods Mol. Biol. | pmid:22528444 |
| Shea BS and Tager AM | Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis. | 2012 | Proc Am Thorac Soc | pmid:22802282 |
| Nakahara K et al. | The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. | 2012 | Mol. Cell | pmid:22633490 |
| Castillo-Badillo JA et al. | Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions. | 2012 | Biochim. Biophys. Acta | pmid:22019450 |
| Christopherson KW | PBSCs Sphingoling along S1P/S1P1 axis. | 2012 | Blood | pmid:22262738 |
| Fujii Y et al. | Lymphopenia induced by a novel selective S1P(1) antagonist structurally unrelated to S1P. | 2012 | Biochim. Biophys. Acta | pmid:22265714 |
| Dakroub Z and Kreydiyyeh SI | Sphingosine-1-phosphate is a mediator of TNF-α action on the Na+/K+ ATPase in HepG2 cells. | 2012 | J. Cell. Biochem. | pmid:22271589 |
| Santulli P et al. | Sphingosine pathway deregulation in endometriotic tissues. | 2012 | Fertil. Steril. | pmid:22277765 |
| Golan K et al. | S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. | 2012 | Blood | pmid:22279055 |