| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dilatation, Pathologic | D004108 | 5 associated lipids |
| Pregnancy, Ectopic | D011271 | 5 associated lipids |
| Anemia, Aplastic | D000741 | 6 associated lipids |
| Peripheral Arterial Disease | D058729 | 7 associated lipids |
| Teratocarcinoma | D018243 | 7 associated lipids |
| Rhabdomyosarcoma | D012208 | 7 associated lipids |
| Eye Abnormalities | D005124 | 7 associated lipids |
| Multiple Sclerosis, Relapsing-Remitting | D020529 | 7 associated lipids |
| Mycobacterium Infections, Nontuberculous | D009165 | 8 associated lipids |
| Thrombocythemia, Essential | D013920 | 9 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mitra P et al. | Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17050692 |
| Yatomi Y | [Elucidation of the functional roles of lysophospholipid mediators and its application in laboratory medicine]. | 2006 | Rinsho Byori | pmid:16913663 |
| Berdyshev EV et al. | De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. | 2006 | Cell. Signal. | pmid:16529909 |
| Schubert R | Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction? | 2006 | Cardiovasc. Res. | pmid:16542647 |
| Ochi R et al. | Sphingosine-1-phosphate effects on guinea pig atrial myocytes: Alterations in action potentials and K+ currents. | 2006 | Cardiovasc. Res. | pmid:16545787 |
| Jiang X and Han X | Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach. | 2006 | J. Lipid Res. | pmid:16682747 |
| Zhang YH et al. | Sphingosine-1-phosphate via activation of a G-protein-coupled receptor(s) enhances the excitability of rat sensory neurons. | 2006 | J. Neurophysiol. | pmid:16723416 |
| Zhang YH et al. | Intracellular sphingosine 1-phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons. | 2006 | J. Physiol. (Lond.) | pmid:16740613 |
| Olivera A et al. | IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses. | 2006 | J. Biol. Chem. | pmid:16316995 |
| Kawamori T et al. | Sphingosine kinase 1 is up-regulated in colon carcinogenesis. | 2006 | FASEB J. | pmid:16319132 |
| Roviezzo F et al. | Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation. | 2006 | FASEB J. | pmid:16322129 |
| Whetzel AM et al. | Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. | 2006 | Circ. Res. | pmid:16960101 |
| El-Shewy HM et al. | Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. | 2006 | J. Biol. Chem. | pmid:16926156 |
| von Wenckstern H et al. | The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology. | 2006 Jul-Aug | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:16830220 |
| Pan CY et al. | Lysophospholipids regulate excitability and exocytosis in cultured bovine chromaffin cells. | 2007 | J. Neurochem. | pmid:17630986 |
| Shimizu T et al. | Sphingosine 1-phosphate receptor 2 negatively regulates neointimal formation in mouse arteries. | 2007 | Circ. Res. | pmid:17872461 |
| Kunisawa J et al. | Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. | 2007 | J. Exp. Med. | pmid:17875673 |
| Klingenberg R et al. | Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17761943 |
| Argraves KM and Argraves WS | HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects. | 2007 | J. Lipid Res. | pmid:17698855 |
| Min J et al. | (Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. | 2007 | Mol. Cancer Res. | pmid:17699106 |
| Tani M et al. | Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity. | 2007 | FEBS Lett. | pmid:17825823 |
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| Liao JJ et al. | Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors. | 2007 | J. Biol. Chem. | pmid:17121832 |
| Sanchez T et al. | Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17431187 |
| Jang S et al. | Cytochemical alterations in the rat retina by LPS administration. | 2007 | Neurochem. Res. | pmid:17160463 |
| Harvey KA et al. | Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation. | 2007 | J. Cell. Physiol. | pmid:17167780 |
| Blondeau N et al. | Distribution of sphingosine kinase activity and mRNA in rodent brain. | 2007 | J. Neurochem. | pmid:17623044 |
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| Pchejetski D et al. | Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis. | 2007 | Circ. Res. | pmid:17158340 |
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| Phan VH et al. | Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila. | 2007 | Dev. Biol. | pmid:17706961 |
| Mechtcheriakova D et al. | Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. | 2007 | Cell. Signal. | pmid:17113265 |
| Brahmbhatt VV et al. | Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid. | 2007 | Chem. Phys. Lipids | pmid:17126823 |
| Smicun Y et al. | S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells. | 2007 | Gynecol. Oncol. | pmid:17716713 |
| Barthomeuf C | Inhibition of S1P-induced angiogenesis, metastasis and inflammation by dietary polyphenols. | 2007 | Free Radic. Biol. Med. | pmid:17189837 |
| Currie JC et al. | MT1-MMP down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells: a molecular link between pro-MMP-2 activation, chemotaxis, and cell survival. | 2007 | J. Biol. Chem. | pmid:17229722 |
| Beech DJ | Bipolar phospholipid sensing by TRPC5 calcium channel. | 2007 | Biochem. Soc. Trans. | pmid:17233612 |
| Kunisawa J et al. | Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. | 2007 | Blood | pmid:17234743 |
| Walzer T et al. | Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor. | 2007 | Nat. Immunol. | pmid:17965716 |
| Yang Q | Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival. | 2007 | Cardiovasc. Res. | pmid:17331485 |
| Landeen LK et al. | Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17337593 |
| Maeda Y et al. | Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3. | 2007 | J. Immunol. | pmid:17339438 |
| Serriere-Lanneau V et al. | The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. | 2007 | FASEB J. | pmid:17341687 |
| Means CK et al. | Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17293497 |
| Aoki S et al. | The suppressive effect of sphingosine 1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins alpha(5)beta(1) and alpha(v)beta(3). | 2007 | J. Thromb. Haemost. | pmid:17403093 |
| Novgorodov AS et al. | Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. | 2007 | FASEB J. | pmid:17255471 |
| Masuko K et al. | Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of prostaglandin E2 from human articular chondrocytes. | 2007 | BMC Musculoskelet Disord | pmid:17374154 |
| Young N and Van Brocklyn JR | Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness. | 2007 | Exp. Cell Res. | pmid:17376432 |
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| Zhao Y et al. | Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. | 2007 | J. Biol. Chem. | pmid:17379599 |
| Sato K et al. | Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes. | 2007 | J. Neurochem. | pmid:17931360 |
| Matsuo Y et al. | Newly developed reconstituted high-density lipoprotein containing sphingosine-1-phosphate induces endothelial tube formation. | 2007 | Atherosclerosis | pmid:17118370 |
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| Morales A et al. | Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo. | 2007 | Oncogene | pmid:16862171 |
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| Sato K et al. | HDL-like lipoproteins in cerebrospinal fluid affect neural cell activity through lipoprotein-associated sphingosine 1-phosphate. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17544365 |
| Levine YC et al. | Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway. | 2007 | J. Biol. Chem. | pmid:17519230 |
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| Huang MC et al. | Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice. | 2007 | J. Immunol. | pmid:17513728 |
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| Park KS et al. | S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17349972 |
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| Hudson NK et al. | Modulation of human arterial tone during pregnancy: the effect of the bioactive metabolite sphingosine-1-phosphate. | 2007 | Biol. Reprod. | pmid:17409372 |
| Itagaki K et al. | Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17626797 |
| Iwaki S et al. | Intracellular trafficking pathway of yeast long-chain base kinase Lcb4, from its synthesis to its degradation. | 2007 | J. Biol. Chem. | pmid:17686782 |
| Kim K et al. | Sphingosine 1-phosphate (S1P) induces shape change in rat C6 glioma cells through the S1P2 receptor: development of an agonist for S1P receptors. | 2007 | J. Pharm. Pharmacol. | pmid:17637200 |
| Kurashima Y et al. | Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy. | 2007 | J. Immunol. | pmid:17641024 |
| Kawanabe T et al. | Sphingosine 1-phosphate accelerates wound healing in diabetic mice. | 2007 | J. Dermatol. Sci. | pmid:17643267 |
| Suzuki H et al. | Inducible nitric oxide has protective effect on fumonisin B1 hepatotoxicity in mice via modulation of sphingosine kinase. | 2007 | Toxicology | pmid:17095132 |
| Brizuela L et al. | Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways. | 2007 | J. Lipid Res. | pmid:17609523 |
| Jin ZQ et al. | A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury. | 2007 | Cardiovasc. Res. | pmid:17610857 |
| Karahatay S et al. | Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. | 2007 | Cancer Lett. | pmid:17619081 |
| Murph M and Mills GB | Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression. | 2007 | Expert Rev Mol Med | pmid:17935635 |
| Oskeritzian CA et al. | Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. | 2007 | Pharmacol. Ther. | pmid:17669501 |
| Xu M et al. | Sphingosine 1-phosphate rapidly increases endothelial barrier function independently of VE-cadherin but requires cell spreading and Rho kinase. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17670896 |
| Santucci MB et al. | Sphingosine 1-phosphate promotes antigen processing and presentation to CD4+ T cells in Mycobacterium tuberculosis-infected monocytes. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17673170 |
| Tao R et al. | Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes. | 2007 | Cardiovasc. Res. | pmid:17320845 |
| Roviezzo F et al. | Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17322125 |
| Wong RC et al. | Anti-apoptotic effect of sphingosine-1-phosphate and platelet-derived growth factor in human embryonic stem cells. | 2007 | Stem Cells Dev. | pmid:18047416 |
| Herzinger T et al. | Sphingosine-1-phosphate signaling and the skin. | 2007 | Am J Clin Dermatol | pmid:18039015 |
| Zhu HY and Da WM | [Regulation of immunity by sphingosine 1-phosphate and its G protein-coupled receptors--review]. | 2007 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:18088493 |
| Igarashi J et al. | Hydrogen peroxide induces S1P1 receptors and sensitizes vascular endothelial cells to sphingosine 1-phosphate, a platelet-derived lipid mediator. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:16943246 |