Morris MA et al. |
Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells. |
2011 |
Autoimmunity |
pmid:20695767
|
Lépine S et al. |
Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage. |
2011 |
J. Biol. Chem. |
pmid:22052905
|
Kotani M et al. |
[Bone and calcium update; bone research update. Trafficking of osteoclast precursors visualized by intravital imaging technology]. |
2011 |
Clin Calcium |
pmid:22133828
|
Eichner A and Sixt M |
Setting the clock for recirculating lymphocytes. |
2011 |
Sci Signal |
pmid:22067458
|
Okamoto Y et al. |
[Cardiovascular function of sphingosine 1-phosphate signaling]. |
2011 |
Seikagaku |
pmid:21800684
|
Siow D and Wattenberg B |
The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism. |
2011 |
Crit. Rev. Biochem. Mol. Biol. |
pmid:21864225
|
Adyshev DM et al. |
Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement. |
2011 |
Cell. Signal. |
pmid:21864676
|
Bieberich E |
There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells. |
2011 |
Neurochem. Res. |
pmid:21136155
|
Kikuta J et al. |
S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis. |
2011 |
Rheumatol. Int. |
pmid:21113810
|
Hu PF et al. |
Sphingosine-1-phosphate: a potential therapeutic target for rheumatoid arthritis. |
2011 |
Mol. Biol. Rep. |
pmid:21116853
|
Xia P and Wadham C |
Sphingosine 1-phosphate, a key mediator of the cytokine network: juxtacrine signaling. |
2011 |
Cytokine Growth Factor Rev. |
pmid:21051273
|
Cho MC et al. |
Involvement of sphingosine-1-phosphate/RhoA/Rho-kinase signaling pathway in corporal fibrosis following cavernous nerve injury in male rats. |
2011 |
J Sex Med |
pmid:21143420
|
Li C et al. |
Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. |
2011 |
J. Hepatol. |
pmid:21145832
|
Zhao Y et al. |
Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. |
2011 |
Am. J. Respir. Cell Mol. Biol. |
pmid:21148740
|
Lai WQ et al. |
Sphingosine kinase and sphingosine 1-phosphate in asthma. |
2011 |
Biosci. Rep. |
pmid:21091442
|
Sabbadini RA |
Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration. |
2011 |
Br. J. Pharmacol. |
pmid:21091645
|
Lee YS et al. |
Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G(2) /M phase arrest. |
2011 |
Cell Prolif. |
pmid:21645154
|
Edmonds Y et al. |
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling. |
2011 |
Pharmacol. Ther. |
pmid:21906625
|
Baranowski M and Górski J |
Heart sphingolipids in health and disease. |
2011 |
Adv. Exp. Med. Biol. |
pmid:21910081
|
Hammad SM |
Blood sphingolipids in homeostasis and pathobiology. |
2011 |
Adv. Exp. Med. Biol. |
pmid:21910082
|
Serafimidis I et al. |
G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis. |
2011 |
Mol. Cell. Biol. |
pmid:21911471
|
Kim BS et al. |
The sphingosine-1-phosphate derivative NHOBTD inhibits angiogenesis both in vitro and in vivo. |
2011 |
Biochem. Biophys. Res. Commun. |
pmid:21888894
|
Blaho VA and Hla T |
Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. |
2011 |
Chem. Rev. |
pmid:21939239
|
Schulze T et al. |
Sphingosine-1-phospate receptor 4 (S1Pâ‚„) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model. |
2011 |
FASEB J. |
pmid:21825036
|
Huwiler A et al. |
A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. |
2011 |
PLoS ONE |
pmid:21829623
|
Liu D et al. |
Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1. |
2011 |
Am. J. Physiol., Cell Physiol. |
pmid:21734188
|
Varo-Sánchez GM et al. |
[Pharmacological targets in multiple sclerosis]. |
2011 |
Rev Neurol |
pmid:21678322
|
Alden KP et al. |
Sphingolipid long chain base phosphates can regulate apoptotic-like programmed cell death in plants. |
2011 |
Biochem. Biophys. Res. Commun. |
pmid:21683064
|
Walzer T and Vivier E |
G-protein-coupled receptors in control of natural killer cell migration. |
2011 |
Trends Immunol. |
pmid:21664184
|
Poulsen RR et al. |
The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development. |
2011 |
BMC Dev. Biol. |
pmid:21668976
|
Goetzl EJ et al. |
Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia. |
2011 |
J. Clin. Immunol. |
pmid:21671128
|
Donati C et al. |
Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6. |
2011 |
PLoS ONE |
pmid:21629665
|
Liu X et al. |
Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation. |
2011 |
J. Cell. Physiol. |
pmid:21660960
|
Li MH et al. |
Sphingolipid modulation of angiogenic factor expression in neuroblastoma. |
2011 |
Cancer Prev Res (Phila) |
pmid:21576349
|
Bréart B et al. |
Lipid phosphate phosphatase 3 enables efficient thymic egress. |
2011 |
J. Exp. Med. |
pmid:21576386
|
Gu Y et al. |
Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway. |
2011 |
J. Cell Biol. |
pmid:21555463
|
Oo ML et al. |
Engagement of S1Pâ‚-degradative mechanisms leads to vascular leak in mice. |
2011 |
J. Clin. Invest. |
pmid:21555855
|
Baranowski M et al. |
Exercise increases plasma levels of sphingoid base-1 phosphates in humans. |
2011 |
Acta Physiol (Oxf) |
pmid:21535416
|
Kanno T and Nishizaki T |
Endogenous sphingosine 1-phosphate regulates spontaneous glutamate release from mossy fiber terminals via S1P(3) receptors. |
2011 |
Life Sci. |
pmid:21683714
|
Kumar A et al. |
S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. |
2011 |
Cell Death Dis |
pmid:21368890
|
Schröder M et al. |
The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. |
2011 |
Mol. Immunol. |
pmid:21435724
|
Samadi N et al. |
Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance. |
2011 |
Biochimie |
pmid:20709140
|
Takasugi N et al. |
BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. |
2011 |
J. Neurosci. |
pmid:21543615
|
Jackson EK |
Role of sphingosine-1-phosphate in the renal medulla. |
2011 |
Am. J. Physiol. Renal Physiol. |
pmid:21511695
|
Salas A et al. |
Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. |
2011 |
Blood |
pmid:21527515
|
Cohen JA and Chun J |
Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis. |
2011 |
Ann. Neurol. |
pmid:21520239
|
Lim KG et al. |
FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells. |
2011 |
J. Biol. Chem. |
pmid:21464128
|
Jung M et al. |
Anti-ageing effects of a new synthetic sphingolipid (K6EAA-L12) on aged murine skin. |
2011 |
Exp. Dermatol. |
pmid:21366697
|
Pyne S and Pyne NJ |
Translational aspects of sphingosine 1-phosphate biology. |
2011 |
Trends Mol Med |
pmid:21514226
|
Strub GM et al. |
Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. |
2011 |
FASEB J. |
pmid:20959514
|
Hopson KP et al. |
S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells. |
2011 |
Am. J. Physiol., Cell Physiol. |
pmid:21270296
|
Ulrych T et al. |
Release of sphingosine-1-phosphate from human platelets is dependent on thromboxane formation. |
2011 |
J. Thromb. Haemost. |
pmid:21251196
|
Catarzi S et al. |
Redox regulation of ERK1/2 activation induced by sphingosine 1-phosphate in fibroblasts: involvement of NADPH oxidase and platelet-derived growth factor receptor. |
2011 |
Biochim. Biophys. Acta |
pmid:21256191
|
Beljanski V et al. |
Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. |
2011 |
Cancer Biol. Ther. |
pmid:21258214
|
Doyle T et al. |
Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats. |
2011 |
Pain |
pmid:21239112
|
Bouma HR et al. |
Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate. |
2011 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:21245336
|
Aarthi JJ et al. |
Dissecting the role of the S1P/S1PR axis in health and disease. |
2011 |
J. Dent. Res. |
pmid:21248363
|
Sumida GM and Stamer WD |
S1Pâ‚‚ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology. |
2011 |
Am. J. Physiol., Cell Physiol. |
pmid:21289286
|
Sensken SC et al. |
Local inactivation of sphingosine 1-phosphate in lymph nodes induces lymphopenia. |
2011 |
J. Immunol. |
pmid:21289303
|
Lee SY et al. |
Sphingosine-1-phosphate reduces hepatic ischaemia/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice. |
2011 |
Nephrology (Carlton) |
pmid:21272128
|
Allende ML et al. |
Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. |
2011 |
J. Biol. Chem. |
pmid:21173151
|
Cahalan SM et al. |
Actions of a picomolar short-acting S1Pâ‚ agonist in S1Pâ‚-eGFP knock-in mice. |
2011 |
Nat. Chem. Biol. |
pmid:21445057
|
Majeed Y et al. |
Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids. |
2011 |
Br. J. Pharmacol. |
pmid:21108630
|
Chiba Y et al. |
Sphingosine-1-phosphate augments agonist-mediated contraction in the bronchial smooth muscles of mice. |
2011 |
Pharmacol Rep |
pmid:21602610
|
Doyle T et al. |
Sphingosine-1-phosphate acting via the S1Pâ‚ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia. |
2011 |
Neurosci. Lett. |
pmid:21605625
|
Christoffersen C et al. |
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. |
2011 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:21606363
|
Fenger M et al. |
Genetics of the ceramide/sphingosine-1-phosphate rheostat in blood pressure regulation and hypertension. |
2011 |
BMC Genet. |
pmid:21569466
|
Separovic D et al. |
Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization. |
2011 |
Biochem. Biophys. Res. Commun. |
pmid:21545791
|
Spiegel S and Milstien S |
The outs and the ins of sphingosine-1-phosphate in immunity. |
2011 |
Nat. Rev. Immunol. |
pmid:21546914
|
Argraves KM et al. |
S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease. |
2011 |
Lipids Health Dis |
pmid:21554699
|
Soleimani R et al. |
Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. |
2011 |
PLoS ONE |
pmid:21559342
|
Finney CA et al. |
S1P is associated with protection in human and experimental cerebral malaria. |
2011 |
Mol. Med. |
pmid:21556483
|
Arnon TI et al. |
GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. |
2011 |
Science |
pmid:21960637
|
El-Shewy HM et al. |
Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. |
2011 |
Mol. Endocrinol. |
pmid:22016563
|
Sola A et al. |
Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration. |
2011 |
J. Pathol. |
pmid:22025214
|
Wirrig C et al. |
Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries. |
2011 |
J. Cereb. Blood Flow Metab. |
pmid:20551970
|
Serebrov VIu et al. |
[Activity of the sphingomyelin cycle enzymes and concentration of products of sphingomyelin degradation in the rat liver in the course of acute toxic hepatitis]. |
2010 Mar-Apr |
Biomed Khim |
pmid:21341516
|
Bode C et al. |
Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate. |
2010 |
J. Cell. Biochem. |
pmid:20186882
|
Ikeda H et al. |
Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C. |
2010 |
Clin. Chim. Acta |
pmid:20188085
|
Pereira JP et al. |
A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow. |
2010 |
PLoS ONE |
pmid:20174580
|
Yu XQ et al. |
Pharmacokinetic/pharmacodynamic modelling of 2-acetyl-4(5)-tetrahydroxybutyl imidazole-induced peripheral lymphocyte sequestration through increasing lymphoid sphingosine 1-phosphate. |
2010 |
Xenobiotica |
pmid:20175664
|
Aydin M et al. |
The sphingosine-1-phosphate pathway is upregulated in response to partial urethral obstruction in male rats and activates RhoA/Rho-kinase signalling. |
2010 |
BJU Int. |
pmid:20128782
|
Wuertz CM et al. |
p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells. |
2010 |
FASEB J. |
pmid:20739613
|
Bourquin F et al. |
Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. |
2010 |
Structure |
pmid:20696404
|
Hoefer J et al. |
Sphingosine-1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction. |
2010 |
Circ. Res. |
pmid:20671234
|
Tengood JE et al. |
Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis. |
2010 |
Biomaterials |
pmid:20674008
|
Jee BC et al. |
Effect of sphingosine-1-phosphate supplementation on follicular integrity of vitrified-warmed mouse ovarian grafts. |
2010 |
Eur. J. Obstet. Gynecol. Reprod. Biol. |
pmid:20674140
|
Zhang G et al. |
Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules. |
2010 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:20729401
|
Rhee S et al. |
Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis. |
2010 |
Exp. Cell Res. |
pmid:19796636
|
Roviezzo F et al. |
Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse. |
2010 |
Am. J. Respir. Cell Mol. Biol. |
pmid:19556602
|
Lan T et al. |
Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry. |
2010 |
Biomed. Chromatogr. |
pmid:20352614
|
Förster A et al. |
Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate. |
2010 |
Kidney Int. |
pmid:20375982
|
Wang F et al. |
Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice. |
2010 |
J. Clin. Invest. |
pmid:20978351
|
Coelho RP et al. |
Sphingosine-1-phosphate and oligodendrocytes: from cell development to the treatment of multiple sclerosis. |
2010 |
Prostaglandins Other Lipid Mediat. |
pmid:19808013
|
Abrahan CE et al. |
Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors. |
2010 |
Invest. Ophthalmol. Vis. Sci. |
pmid:19797232
|
Meacci E et al. |
Functional interaction between TRPC1 channel and connexin-43 protein: a novel pathway underlying S1P action on skeletal myogenesis. |
2010 |
Cell. Mol. Life Sci. |
pmid:20614160
|
Sumida GM and Stamer WD |
Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayers. |
2010 |
Invest. Ophthalmol. Vis. Sci. |
pmid:20592229
|
Cusack KP and Stoffel RH |
S1P(1) receptor agonists: Assessment of selectivity and current clinical activity. |
2010 |
Curr Opin Drug Discov Devel |
pmid:20597031
|
Weis T et al. |
Sphingosine 1-phosphate (S1P) induces expression of E-selectin and adhesion of monocytes via intracellular signalling pathways in vascular endothelial cells. |
2010 |
Eur. J. Cell Biol. |
pmid:20656374
|
Weigert A et al. |
Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells. |
2010 |
Blood |
pmid:20197547
|