| MeSH term | MeSH ID | Detail |
|---|---|---|
| Insulinoma | D007340 | 28 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xiong Y et al. | Sphingosine kinases are not required for inflammatory responses in macrophages. | 2013 | J. Biol. Chem. | pmid:24081141 |
| Riccitelli E et al. | Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival. | 2013 | PLoS ONE | pmid:23826381 |
| Kim YD et al. | Effects of sphingosine-1-phosphate on pacemaker activity of interstitial cells of Cajal from mouse small intestine. | 2013 | Mol. Cells | pmid:23307289 |
| Sharma N et al. | Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells. | 2013 | J. Leukoc. Biol. | pmid:23345392 |
| Chang CH et al. | Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro. | 2013 | Acta Pharmacol. Sin. | pmid:23377549 |
| Takuwa Y et al. | Sphingosine-1-phosphate signaling in physiology and diseases. | 2012 Sep-Oct | Biofactors | pmid:22674845 |
| Iwaki S et al. | Posttranscriptional regulation of expression of plasminogen activator inhibitor type-1 by sphingosine 1-phosphate in HepG2 liver cells. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22819712 |
| Fournie P et al. | Sphingosine-1 phosphate prevents ethanol-induced corneal epithelial apoptosis. | 2012 Mar-Apr | Indian J Ophthalmol | pmid:22446906 |
| Tse KW et al. | Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells. | 2012 Jan-Feb | Cell. Immunol. | pmid:22507871 |
| Pyne NJ et al. | Sphingosine 1-phosphate signalling in cancer. | 2012 | Biochem. Soc. Trans. | pmid:22260672 |
| Jin YX et al. | A strategy for enrichment of the bioactive sphingoid base-1-phosphates produced by Hypericum perforatum L. in a balloon type airlift reactor. | 2012 | Bioresour. Technol. | pmid:22940331 |
| Snider AJ et al. | Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22940715 |
| Moon MH et al. | Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes. | 2012 | Int. J. Mol. Med. | pmid:22992945 |
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| Kim CH et al. | Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors. | 2012 | Leukemia | pmid:21769103 |
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| Kwak HI et al. | Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation. | 2012 | Angiogenesis | pmid:22407449 |
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| Su G et al. | Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:21980034 |
| Nagahashi M et al. | Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. | 2012 | Cancer Res. | pmid:22298596 |
| Ratajczak J et al. | A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient. | 2012 | Leukemia | pmid:22343521 |
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