MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sivasubramanian M et al. | Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP+ -treated MN9D cells in vitro. | 2015 | Neuroscience | pmid:25637806 |
Moore AN et al. | Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes. | 1999 | Neuroscience | pmid:10579204 |
Kanno T et al. | Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus. | 2010 | Neuroscience | pmid:20950672 |
Schilling T et al. | Lysophospholipids induce membrane hyperpolarization in microglia by activation of IKCa1 Ca(2+)-dependent K(+) channels. | 2002 | Neuroscience | pmid:11927165 |
Agudo-López A et al. | Involvement of mitochondria on neuroprotective effect of sphingosine-1-phosphate in cell death in an in vitro model of brain ischemia. | 2010 | Neurosci. Lett. | pmid:20045720 |
Muñoz-Sáez E et al. | Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y). | 2015 | Neurosci. Lett. | pmid:25769802 |
Nishimura B et al. | The influences of sphingolipid metabolites on gentamicin-induced hair cell loss of the rat cochlea. | 2010 | Neurosci. Lett. | pmid:20709153 |
Kułakowska A et al. | Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis. | 2010 | Neurosci. Lett. | pmid:20434523 |
Doyle T et al. | Sphingosine-1-phosphate acting via the S1Pâ‚ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia. | 2011 | Neurosci. Lett. | pmid:21605625 |
Esche M et al. | Signalling of sphingosine-1-phosphate in Müller glial cells via the S1P/EDG-family of G-protein-coupled receptors. | 2010 | Neurosci. Lett. | pmid:20540988 |
O'Sullivan S and Dev KK | Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases. | 2017 | Neuropharmacology | pmid:27825807 |
Pan CY et al. | Lysophospholipids elevate [Ca2+]i and trigger exocytosis in bovine chromaffin cells. | 2006 | Neuropharmacology | pmid:16616768 |
Ruiz-Medina J et al. | GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception. | 2011 Jul-Aug | Neuropharmacology | pmid:21352831 |
Pierucci F et al. | Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. | 2017 | Neuropharmacology | pmid:28077289 |
Callihan P et al. | Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. | 2012 | Neuropharmacology | pmid:22016110 |
Zhang ZY et al. | FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis. | 2009 | Neuropathol. Appl. Neurobiol. | pmid:19207263 |
Atkinson D et al. | Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. | 2017 | Neurology | pmid:28077491 |
Antel J and Hohlfeld R | Modulation of sphingosine 1-phosphate signaling in neurologic disease. | 2011 | Neurology | pmid:21360856 |
Pinschewer DD et al. | Impact of sphingosine 1-phosphate modulation on immune outcomes. | 2011 | Neurology | pmid:21339486 |
Mehling M et al. | Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis. | 2011 | Neurology | pmid:21339487 |
Hla T and Brinkmann V | Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. | 2011 | Neurology | pmid:21339489 |
Soliven B et al. | The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. | 2011 | Neurology | pmid:21339490 |
Jang S et al. | Cytochemical alterations in the rat retina by LPS administration. | 2007 | Neurochem. Res. | pmid:17160463 |
Giussani P et al. | Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells. | 2007 | Neurochem. Res. | pmid:17151916 |
Podbielska M et al. | Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis. | 2012 | Neurochem. Res. | pmid:22451227 |
Pasquaré SJ et al. | Involvement of lysophosphatidic acid, sphingosine 1-phosphate and ceramide 1-phosphate in the metabolization of phosphatidic acid by lipid phosphate phosphatases in bovine rod outer segments. | 2008 | Neurochem. Res. | pmid:18288612 |
Bieberich E | There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells. | 2011 | Neurochem. Res. | pmid:21136155 |
Jang S et al. | Changes in iNOS, GFAP and NR1 expression in various brain regions and elevation of sphingosine-1-phosphate in serum after immobilized stress. | 2008 | Neurochem. Res. | pmid:17940874 |
Gassowska M et al. | Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells. | 2014 | Neurochem. Res. | pmid:24452756 |
Bieberich E | It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation. | 2012 | Neurochem. Res. | pmid:22246226 |
Jang S et al. | Modulation of sphingosine 1-phosphate and tyrosine hydroxylase in the stress-induced anxiety. | 2011 | Neurochem. Res. | pmid:21076868 |
Yang Y et al. | Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. | 2016 | Neurochem. Int. | pmid:26921668 |
Molderings GJ et al. | S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands. | 2007 | Neurochem. Int. | pmid:17559976 |
Malaplate-Armand C et al. | Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway. | 2006 | Neurobiol. Dis. | pmid:16626961 |
He X et al. | Deregulation of sphingolipid metabolism in Alzheimer's disease. | 2010 | Neurobiol. Aging | pmid:18547682 |
Lee SY et al. | Sphingosine-1-phosphate reduces hepatic ischaemia/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice. | 2011 | Nephrology (Carlton) | pmid:21272128 |
Kim MG et al. | CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury. | 2011 | Nephrol. Dial. Transplant. | pmid:20702533 |
Hanafusa N et al. | Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. | 2002 | Nephrol. Dial. Transplant. | pmid:11917049 |
Sun XJ et al. | Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis. | 2017 | Nephrol. Dial. Transplant. | pmid:28206609 |
Morales M | [Participation of the phosphatidylinositol-3-kinase/Akt/endothelial-nitric-oxide synthase signaling in the processes of angiogenesis and vascular remodeling]. | 2002 | Nefrologia | pmid:12107910 |
Czyborra C et al. | Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16521006 |
Rümenapp U et al. | Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility. | 2000 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:10651140 |
Bischoff A et al. | Nifedipine inhibits sphinogosine-1-phosphate-induced renovascular contraction in vitro and in vivo. | 2001 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:11534858 |
Alemany R et al. | Regulation and functional roles of sphingosine kinases. | 2007 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:17242884 |
Trifilieff A et al. | Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19636535 |
Meyer zu Heringdrof D et al. | Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8897440 |
Repp H et al. | Activation of a Ca2+-dependent K+ current in mouse fibroblasts by sphingosine-1-phosphate involves the protein tyrosine kinase c-Src. | 2001 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:11284444 |
Jongsma M et al. | Validation of a rapid, non-radioactive method to quantify internalisation of G-protein coupled receptors. | 2007 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:17497135 |
Stuebe S et al. | Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene. | 2008 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:18046543 |
Hemmings DG | Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16570136 |