MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Park K et al. | Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production. | 2013 | J. Invest. Dermatol. | pmid:23856934 |
Ota K et al. | TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts. | 2013 | Endocrinology | pmid:23861379 |
Kotani T et al. | Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor. | 2013 | Biol. Reprod. | pmid:23863409 |
Zhao CG et al. | Sphingosine-1-phosphate is a possible fibrogenic factor in gluteal muscle fibrosis. | 2013 | Physiol Res | pmid:23869887 |
Adada M et al. | Sphingosine-1-phosphate receptor 2. | 2013 | FEBS J. | pmid:23879641 |
Gao X et al. | Aberrant sphingolipid metabolism in the human fallopian tube with ectopic pregnancy. | 2013 | Lipids | pmid:23881382 |
Egom EE et al. | Activation of sphingosine-1-phosphate signalling as a potential underlying mechanism of the pleiotropic effects of statin therapy. | 2013 May-Jun | Crit Rev Clin Lab Sci | pmid:23885725 |
Gorshkova IA et al. | Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest. | 2013 | Life Sci. | pmid:23892195 |
Albinet V et al. | Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. | 2014 | Oncogene | pmid:23893239 |
Olivera A et al. | Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. | 2013 | J. Leukoc. Biol. | pmid:23904439 |
Koch A et al. | PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. | 2013 | Biochim. Biophys. Acta | pmid:23906789 |
Sun X et al. | Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23911438 |
Nishi T et al. | Molecular and physiological functions of sphingosine 1-phosphate transporters. | 2014 | Biochim. Biophys. Acta | pmid:23921254 |
Harijith A et al. | Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins. | 2013 | Am. J. Pathol. | pmid:23933064 |
Weichand B et al. | Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration. | 2013 | Eur. J. Immunol. | pmid:23934754 |
Morad SA et al. | Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells. | 2013 | Biochim. Biophys. Acta | pmid:23939396 |
Kunkel GT et al. | Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. | 2013 | Nat Rev Drug Discov | pmid:23954895 |
Kim ES et al. | Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression. | 2014 | Oncogene | pmid:23955082 |
Xia JY et al. | The adipokine/ceramide axis: key aspects of insulin sensitization. | 2014 | Biochimie | pmid:23969158 |
Kihara A | [Complete metabolic pathway of sphingosine 1-phosphate and its importance as a metabolic intermediate]. | 2013 | Seikagaku | pmid:23980469 |
Zhang O et al. | Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence. | 2013 | Mol. Microbiol. | pmid:23980754 |
Del Galdo S et al. | The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis. | 2013 | Cell. Signal. | pmid:23993968 |
Kihara A | Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids. | 2014 | Biochim. Biophys. Acta | pmid:23994042 |
Herzog BH et al. | Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. | 2013 | Nature | pmid:23995678 |
Zhang J et al. | Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration. | 2013 | Hum. Reprod. | pmid:24001716 |
Herr DR et al. | Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. | 2013 | J. Biol. Chem. | pmid:24003216 |
Dziak R | The role of sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) in regulation of osteoclastic and osteoblastic cells. | 2013 | Immunol. Invest. | pmid:24004055 |
Dave JM et al. | Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). | 2013 | J. Biol. Chem. | pmid:24005669 |
Tanaka K et al. | Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. | 2014 | Clin. Exp. Immunol. | pmid:24028747 |
Che W et al. | Corticosteroids inhibit sphingosine 1-phosphate-induced interleukin-6 secretion from human airway smooth muscle via mitogen-activated protein kinase phosphatase 1-mediated repression of mitogen and stress-activated protein kinase 1. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24032470 |
Sar JI et al. | Sphingosine-1-phosphate stimulated connective tissue growth factor expression in human buccal fibroblasts: Inhibition by epigallocatechin-3-gallate. | 2015 | J. Formos. Med. Assoc. | pmid:24035571 |
Chang N et al. | Sphingosine 1-phosphate receptors negatively regulate collagen type I/III expression in human bone marrow-derived mesenchymal stem cell. | 2014 | J. Cell. Biochem. | pmid:24038457 |
Kowalski GM et al. | Plasma sphingosine-1-phosphate is elevated in obesity. | 2013 | PLoS ONE | pmid:24039766 |
Anderson G and Maes M | Reconceptualizing adult neurogenesis: role for sphingosine-1-phosphate and fibroblast growth factor-1 in co-ordinating astrocyte-neuronal precursor interactions. | 2014 | CNS Neurol Disord Drug Targets | pmid:24040808 |
Babahosseini H et al. | Bioactive sphingolipid metabolites modulate ovarian cancer cell structural mechanics. | 2013 | Integr Biol (Camb) | pmid:24056950 |
Das A et al. | The promotion of mandibular defect healing by the targeting of S1P receptors and the recruitment of alternatively activated macrophages. | 2013 | Biomaterials | pmid:24064148 |
Zhang W et al. | ETS-1-mediated transcriptional up-regulation of CD44 is required for sphingosine-1-phosphate receptor subtype 3-stimulated chemotaxis. | 2013 | J. Biol. Chem. | pmid:24064218 |
Völzke A et al. | Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. | 2014 | Biochim. Biophys. Acta | pmid:24064301 |
Pyne NJ et al. | The role of sphingosine 1-phosphate in inflammation and cancer. | 2014 | Adv Biol Regul | pmid:24070975 |
Garris CS et al. | Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. | 2013 | Nat. Immunol. | pmid:24076635 |
Nguyen-Tran DH et al. | Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. | 2014 | Dis Model Mech | pmid:24077965 |
Xiong Y et al. | Sphingosine kinases are not required for inflammatory responses in macrophages. | 2013 | J. Biol. Chem. | pmid:24081141 |
Kurek K et al. | [The role of sphingolipids in selected cardiovascular diseases]. | 2013 | Postepy Hig Med Dosw (Online) | pmid:24088546 |
Giannouli CC et al. | Visualizing S1P-directed cellular egress by intravital imaging. | 2014 | Biochim. Biophys. Acta | pmid:24090699 |
Baranowski M et al. | Ultramarathon run markedly reduces plasma sphingosine-1-phosphate concentration. | 2014 | Int J Sport Nutr Exerc Metab | pmid:24092763 |
Yuan S et al. | Lipid receptor S1Pâ‚ activation scheme concluded from microsecond all-atom molecular dynamics simulations. | 2013 | PLoS Comput. Biol. | pmid:24098103 |
Beckham TH et al. | Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. | 2013 | PLoS ONE | pmid:24098536 |
Knapp M et al. | Dose-dependent effect of aspirin on the level of sphingolipids in human blood. | 2013 | Adv Med Sci | pmid:24101372 |
Mendes-Braz M et al. | The effects of glucose and lipids in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischaemia-reperfusion. | 2014 | Liver Int. | pmid:24107124 |
Kendig DM et al. | Sphingosine-1-phosphate induced contraction of bladder smooth muscle. | 2013 | Eur. J. Pharmacol. | pmid:24120660 |
Knapp M et al. | Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:24120760 |
Roviezzo F et al. | Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate. | 2014 | Clin. Sci. | pmid:24131465 |
Wang X et al. | Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. | 2013 | Biochem. Pharmacol. | pmid:24134913 |
Qin Z et al. | Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. | 2014 | Mol. Cancer Ther. | pmid:24140934 |
Ryu JM et al. | Sphingosine-1-phosphate-induced Flk-1 transactivation stimulates mouse embryonic stem cell proliferation through S1P1/S1P3-dependent β-arrestin/c-Src pathways. | 2014 | Stem Cell Res | pmid:24145189 |
Whisler JA et al. | Control of perfusable microvascular network morphology using a multiculture microfluidic system. | 2014 | Tissue Eng Part C Methods | pmid:24151838 |
Wirotanseng LN et al. | Gq rather than G11 preferentially mediates nociceptor sensitization. | 2013 | Mol Pain | pmid:24156378 |
Yu Y et al. | Phospholipid transfer protein deficiency decreases the content of S1P in HDL via the loss of its transfer capability. | 2014 | Lipids | pmid:24158769 |
Polzin A et al. | Aspirin inhibits release of platelet-derived sphingosine-1-phosphate in acute myocardial infarction. | 2013 | Int. J. Cardiol. | pmid:24169533 |
Radi ZA and Vogel MW | Gastric parietal cell atrophy and depletion after administration of a sphingosine-1-phosphate 1 inhibitor. | 2014 | Toxicol Pathol | pmid:24178572 |
Shayegi N et al. | CXCR4 blockade and sphingosine-1-phosphate activation facilitate engraftment of haematopoietic stem and progenitor cells in a non-myeloablative transplant model. | 2014 | Br. J. Haematol. | pmid:24180707 |
Selhub J et al. | Dietary vitamin B6 intake modulates colonic inflammation in the IL10-/- model of inflammatory bowel disease. | 2013 | J. Nutr. Biochem. | pmid:24183308 |
Ratajczak MZ et al. | The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and cancer cells. | 2014 | Expert Opin. Ther. Targets | pmid:24188167 |
Lim SH et al. | Complementary effects of ciclopirox olamine, a prolyl hydroxylase inhibitor and sphingosine 1-phosphate on fibroblasts and endothelial cells in driving capillary sprouting. | 2013 | Integr Biol (Camb) | pmid:24190477 |
Chawla S et al. | Exogenous sphingosine 1-phosphate protects murine splenocytes against hypoxia-induced injury. | 2014 | Lipids | pmid:24190514 |
Takeo T et al. | Investigations of motility and fertilization potential in thawed cryopreserved mouse sperm from cold-stored epididymides. | 2014 | Cryobiology | pmid:24201107 |
Nagahashi M et al. | Sphingosine-1-phosphate in chronic intestinal inflammation and cancer. | 2014 | Adv Biol Regul | pmid:24210073 |
Ito S et al. | Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes. | 2013 | Coron. Artery Dis. | pmid:24212262 |
Li F et al. | Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death. | 2014 | Hum. Reprod. | pmid:24221908 |
Kajimoto T et al. | Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes. | 2013 | Nat Commun | pmid:24231649 |
Speak AO et al. | Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1. | 2014 | Blood | pmid:24235134 |
Bigaud M et al. | Second generation S1P pathway modulators: research strategies and clinical developments. | 2014 | Biochim. Biophys. Acta | pmid:24239768 |
Lamichhane A et al. | Nutritional components regulate the gut immune system and its association with intestinal immune disease development. | 2013 | J. Gastroenterol. Hepatol. | pmid:24251698 |
Emery SM et al. | Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24259678 |
Abuhusain HJ et al. | A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis. | 2013 | J. Biol. Chem. | pmid:24265321 |
Bolli MH et al. | Novel S1P1 receptor agonists--part 1: From pyrazoles to thiophenes. | 2013 | J. Med. Chem. | pmid:24266709 |
Ohkuni A et al. | Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway. | 2013 | Biochem. Biophys. Res. Commun. | pmid:24269233 |
Chen JJ et al. | Non-genomic rapid responses via progesterone in human peripheral T cells are not indirectly mimicked by sphingosine 1-phosphate. | 2014 | Steroids | pmid:24269742 |
Simmons S and Ishii M | Sphingosine-1-phosphate: a master regulator of lymphocyte egress and immunity. | 2014 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:24276789 |
Rao PV | Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma. | 2014 Mar-Apr | J Ocul Pharmacol Ther | pmid:24283588 |
Banitalebi E et al. | The effect of resistance training on plasma S1P level and gene expression of S1P1,2,3 receptors in male Wistar rats. | 2013 | Minerva Endocrinol. | pmid:24285107 |
Zeng Y et al. | Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24285115 |
Rokka J et al. | 19F/18F exchange synthesis for a novel [18F]S1P3-radiopharmaceutical. | 2013 | J Labelled Comp Radiopharm | pmid:24285478 |
Fayyaz S et al. | Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype. | 2014 | Diabetologia | pmid:24292566 |
Shen Z et al. | Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α). | 2014 | Cell Stress Chaperones | pmid:24293320 |
Liu M et al. | Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein. | 2014 | J. Biol. Chem. | pmid:24318881 |
Huang YL et al. | Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells. | 2014 | Cell. Signal. | pmid:24333325 |
Guo L et al. | Roles of sphingosine-1-phosphate in reproduction. | 2014 | Reprod Sci | pmid:24336672 |
Walls SM et al. | Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila. | 2013 | PLoS Genet. | pmid:24339790 |
Huang K et al. | AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose. | 2014 | Cell. Signal. | pmid:24342046 |
Maeda Y et al. | S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1. | 2014 | Int. Immunol. | pmid:24343820 |
Xiang SY et al. | PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. | 2013 | Sci Signal | pmid:24345679 |
Mendelson K et al. | Sphingosine 1-phosphate signalling. | 2014 | Development | pmid:24346695 |
Yu H et al. | Insulin protects apoptotic cardiomyocytes from hypoxia/reoxygenation injury through the sphingosine kinase/sphingosine 1-phosphate axis. | 2013 | PLoS ONE | pmid:24349009 |
Gil-Ortega M et al. | Ex vivo microperfusion system of the adipose organ: a new approach to studying the mobilization of adipose cell populations. | 2014 | Int J Obes (Lond) | pmid:24357852 |
Slattum G et al. | Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P. | 2014 | Curr. Biol. | pmid:24361067 |
Ohkawa R et al. | [Sphingolipids, possible biomarkers for atherosclerotic disorders]. | 2013 | Rinsho Byori | pmid:24369591 |
Miller DS | Sphingolipid signaling reduces basal P-glycoprotein activity in renal proximal tubule. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24385389 |
Tibboel J et al. | Sphingolipids in lung growth and repair. | 2014 | Chest | pmid:24394822 |
Pyszko J and Strosznajder JB | Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells. | 2014 | Mol. Neurobiol. | pmid:24399507 |