MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Terashita T et al. | Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells. | 2016 | Respir. Res. | pmid:27829417 |
Pfaff M et al. | Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. | 2005 | Respir. Res. | pmid:15927078 |
Roth Z and Hansen PJ | Disruption of nuclear maturation and rearrangement of cytoskeletal elements in bovine oocytes exposed to heat shock during maturation. | 2005 | Reproduction | pmid:15695618 |
Hannoun A et al. | Addition of sphingosine-1-phosphate to human oocyte culture medium decreases embryo fragmentation. | 2010 | Reprod. Biomed. Online | pmid:20093086 |
Tan SJ et al. | Targeted anti-apoptosis activity for ovarian protection against chemotherapy-induced ovarian gonadotoxicity. | 2014 | Reprod. Biomed. Online | pmid:25246113 |
Singh AT et al. | Sphingosine-sphingosine-1-phosphate pathway regulates trophoblast differentiation and syncytialization. | 2012 | Reprod. Biomed. Online | pmid:22197131 |
Tsai YC et al. | Antiapoptotic agent sphingosine-1-phosphate protects vitrified murine ovarian grafts. | 2014 | Reprod Sci | pmid:23793475 |
Guo L et al. | Roles of sphingosine-1-phosphate in reproduction. | 2014 | Reprod Sci | pmid:24336672 |
Djanani A et al. | Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes. | 2003 | Regul. Pept. | pmid:12972327 |
Incorvaia C et al. | Anaphylaxis: an update on its understanding and management. | 2010 | Recent Pat Inflamm Allergy Drug Discov | pmid:20100165 |
Morishige J et al. | A clean-up technology for the simultaneous determination of lysophosphatidic acid and sphingosine-1-phosphate by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a phosphate-capture molecule, Phos-tag. | 2010 | Rapid Commun. Mass Spectrom. | pmid:20213695 |
von Bismarck P et al. | IKK NBD peptide inhibits LPS induced pulmonary inflammation and alters sphingolipid metabolism in a murine model. | 2012 | Pulm Pharmacol Ther | pmid:22469869 |
Racké K et al. | Potential role of EDG receptors and lysophospholipids as their endogenous ligands in the respiratory tract. | 2000 | Pulm Pharmacol Ther | pmid:10873548 |
Bourquin F et al. | PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism. | 2011 | Protein Sci. | pmid:21710479 |
Gibbs TC et al. | Signal transduction responses to lysophosphatidic acid and sphingosine 1-phosphate in human prostate cancer cells. | 2009 | Prostate | pmid:19536794 |
Sekine Y et al. | HDL and sphingosine-1-phosphate activate stat3 in prostate cancer DU145 cells via ERK1/2 and S1P receptors, and promote cell migration and invasion. | 2011 | Prostate | pmid:20979115 |
Snider AJ et al. | Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22940715 |
Knapp M et al. | Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:24120760 |
Ratajczak MZ et al. | An emerging link in stem cell mobilization between activation of the complement cascade and the chemotactic gradient of sphingosine-1-phosphate. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:22981511 |
Kim HL et al. | Characterization of N,N,-dimethyl-D-erythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18316219 |
Ahmad M et al. | The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16647641 |
Linke B et al. | Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22732087 |
Olivera A | Unraveling the complexities of sphingosine-1-phosphate function: the mast cell model. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18403224 |
Zhang W et al. | Sphingosine-1-phosphate receptor-2 mediated NFκB activation contributes to tumor necrosis factor-α induced VCAM-1 and ICAM-1 expression in endothelial cells. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23770055 |
Yatomi Y et al. | Sphingosine 1-phosphate: synthesis and release. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324700 |
Goetzl EJ | Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324701 |
Olivera A and Spiegel S | Sphingosine kinase: a mediator of vital cellular functions. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324702 |
Hla T | Sphingosine 1-phosphate receptors. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324703 |
Mandala SM | Sphingosine-1-phosphate phosphatases. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324704 |
Lynch KR and Macdonald TL | Structure activity relationships of lysophospholipid mediators. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324706 |
Panetti TS et al. | Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324710 |
Maceyka M et al. | Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099387 |
Baranowski M et al. | Pioglitazone induces de novo ceramide synthesis in the rat heart. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259076 |
Chun J | Lysophospholipids in the nervous system. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099390 |
Rosen H | Chemical approaches to the lysophospholipid receptors. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099402 |
Coelho RP et al. | Sphingosine-1-phosphate and oligodendrocytes: from cell development to the treatment of multiple sclerosis. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:19808013 |
Zabielski P et al. | Partial hepatectomy activates production of the pro-mitotic intermediates of the sphingomyelin signal transduction pathway in the rat liver. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17499747 |
Butler J et al. | Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165029 |
Chae SS et al. | Constitutive expression of the S1P1 receptor in adult tissues. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165038 |
Schmidt H et al. | LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085324 |
Li Z et al. | Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15967165 |
Cutignano A et al. | UPLC-MS/MS method for analysis of sphingosine 1-phosphate in biological samples. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20601074 |
Zabielski P et al. | Bezafibrate decreases growth stimulatory action of the sphingomyelin signaling pathway in regenerating rat liver. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18024222 |
Lee YM et al. | A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17991617 |
Thompson B et al. | Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16846783 |
Long JS et al. | The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16846788 |
Hammad SM et al. | Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18166496 |
Zabielski P et al. | The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20599517 |
Lampasso JD et al. | Sphingosine-1-phosphate effects on PKC isoform expression in human osteoblastic cells. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728164 |
Son DJ et al. | Enhanced release of sphingosine-1-phosphate from hypercholesterolemic platelets: role in development of hypercholesterolemic atherosclerosis. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18571912 |