MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Baranowski M and Górski J | Heart sphingolipids in health and disease. | 2011 | Adv. Exp. Med. Biol. | pmid:21910081 |
Hammad SM | Blood sphingolipids in homeostasis and pathobiology. | 2011 | Adv. Exp. Med. Biol. | pmid:21910082 |
Olivera A and Rivera J | An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease. | 2011 | Adv. Exp. Med. Biol. | pmid:21713655 |
Siow DL et al. | Sphingosine kinase localization in the control of sphingolipid metabolism. | 2011 | Adv. Enzyme Regul. | pmid:21075134 |
Pyne NJ et al. | New aspects of sphingosine 1-phosphate signaling in mammalian cells. | 2009 | Adv. Enzyme Regul. | pmid:19534035 |
Birbes H et al. | Mitochondria and ceramide: intertwined roles in regulation of apoptosis. | 2002 | Adv. Enzyme Regul. | pmid:12123710 |
Serra M and Saba JD | Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. | 2010 | Adv. Enzyme Regul. | pmid:19914275 |
Cuvillier O et al. | Hypoxia, therapeutic resistance, and sphingosine 1-phosphate. | 2013 | Adv. Cancer Res. | pmid:23290779 |
Alshaker H et al. | Therapeutic potential of targeting SK1 in human cancers. | 2013 | Adv. Cancer Res. | pmid:23290780 |
Heffernan-Stroud LA and Obeid LM | Sphingosine kinase 1 in cancer. | 2013 | Adv. Cancer Res. | pmid:23290781 |
Knapp M et al. | Dose-dependent effect of aspirin on the level of sphingolipids in human blood. | 2013 | Adv Med Sci | pmid:24101372 |
Knapp M et al. | Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure. | 2012 | Adv Med Sci | pmid:22296975 |
Pyne NJ et al. | The role of sphingosine 1-phosphate in inflammation and cancer. | 2014 | Adv Biol Regul | pmid:24070975 |
Carroll B et al. | Sphingolipids in the DNA damage response. | 2015 | Adv Biol Regul | pmid:25434743 |
Siow D et al. | Regulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1. | 2015 | Adv Biol Regul | pmid:25319495 |
Ebenezer DL et al. | Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. | 2017 | Adv Biol Regul | pmid:27720306 |
Maczis M et al. | Sphingosine-1-phosphate and estrogen signaling in breast cancer. | 2016 | Adv Biol Regul | pmid:26601898 |
Nagahashi M et al. | Sphingosine-1-phosphate in chronic intestinal inflammation and cancer. | 2014 | Adv Biol Regul | pmid:24210073 |
Beech DJ | Integration of transient receptor potential canonical channels with lipids. | 2012 | Acta Physiol (Oxf) | pmid:21624095 |
Baranowski M et al. | Exercise increases plasma levels of sphingoid base-1 phosphates in humans. | 2011 | Acta Physiol (Oxf) | pmid:21535416 |
Törnquist K | Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells. | 2012 | Acta Physiol (Oxf) | pmid:21338471 |
Kusch A et al. | Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury. | 2013 | Acta Physiol (Oxf) | pmid:23432924 |
Xu M et al. | FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. | 2014 | Acta Pharmacol. Sin. | pmid:25399649 |
Im DS | Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors. | 2010 | Acta Pharmacol. Sin. | pmid:20729877 |
Chang CH et al. | Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro. | 2013 | Acta Pharmacol. Sin. | pmid:23377549 |
Xu CB et al. | Sphingosine signaling and atherogenesis. | 2004 | Acta Pharmacol. Sin. | pmid:15210056 |
Milstien S et al. | Sphingosine 1-phosphate in neural signalling and function. | 2007 | Acta Paediatr Suppl | pmid:17391440 |
Michel MC et al. | Vascular effects of sphingolipids. | 2007 | Acta Paediatr Suppl | pmid:17391441 |
Goetzl EJ et al. | Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunity. | 2007 | Acta Paediatr Suppl | pmid:17391442 |
Couttas TA et al. | Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis. | 2014 | Acta Neuropathol Commun | pmid:24456642 |
Wang Z et al. | The Effect of Sphingosine 1-Phosphate/Sphingosine 1-Phosphate Receptor on Neutrophil Function and the Relevant Signaling Pathway. | 2015 | Acta Haematol. | pmid:25872153 |
Zhao Z et al. | Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720. | 2017 | Acta Haematol. | pmid:27802432 |
Melnik BC | Rosacea: The Blessing of the Celts - An Approach to Pathogenesis Through Translational Research. | 2016 | Acta Derm. Venereol. | pmid:26304030 |
Tang H et al. | Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits. | 2015 | Acta Cir Bras | pmid:26560422 |
Hsia K et al. | Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro. | 2017 | Acta Biomater | pmid:28110073 |
Ogle ME et al. | Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. | 2014 | Acta Biomater | pmid:25128750 |
Murakami M et al. | Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitment. | 2014 | Acta Biomater | pmid:25038462 |
Scott EA et al. | Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen. | 2010 | Acta Biomater | pmid:19607945 |
Zhang J and Song J | Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. | 2014 | Acta Biomater | pmid:24631657 |
Dygas A et al. | Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells. | 1999 | Acta Biochim. Pol. | pmid:10453985 |
Wójcik M and Barańska J | Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells. | 1999 | Acta Biochim. Pol. | pmid:10453988 |
Igarashi Y and Yatomi Y | Sphingosine 1-phosphate is a blood constituent released from activated platelets, possibly playing a variety of physiological and pathophysiological roles. | 1998 | Acta Biochim. Pol. | pmid:9821862 |
Lundblad C et al. | Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat. | 2013 | Acta Anaesthesiol Scand | pmid:23683126 |
Deng H et al. | Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis. | 2013 | ACS Med Chem Lett | pmid:24900589 |
Santos WL and Lynch KR | Drugging sphingosine kinases. | 2015 | ACS Chem. Biol. | pmid:25384187 |
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