MeSH term | MeSH ID | Detail |
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Peripheral Arterial Disease | D058729 | 7 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chung FY et al. | Signaling mechanisms of sphingosine 1-phosphate-induced ERK1/2 activation in cultured feline esophageal smooth muscle cells. | 2008 | Arch. Pharm. Res. | pmid:19023540 |
Shin KO et al. | Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. | 2014 | Arch. Pharm. Res. | pmid:24687256 |
Choi CH et al. | Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development. | 2007 | Arch. Pharm. Res. | pmid:17489368 |
Kim DH et al. | Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice. | 2007 | Arch. Pharm. Res. | pmid:17879749 |
Pierucci F et al. | Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. | 2017 | Arch. Toxicol. | pmid:27318803 |
Klingenberg R et al. | Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17761943 |
Hayashi H et al. | FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19325137 |
Sanchez T et al. | Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17431187 |
Ruiz M et al. | High-Density Lipoprotein-Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:27879252 |
Keul P et al. | The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17158351 |
Walter DH et al. | Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17158356 |
Auge N et al. | Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12482824 |
Medlin MD et al. | Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20702813 |
Bolick DT et al. | Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:15761190 |
Jang C et al. | Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19112163 |
Panetti TS et al. | Sphingosine-1-phosphate and lysophosphatidic acid stimulate endothelial cell migration. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10764666 |
Brinck JW et al. | Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection. | 2016 | Arterioscler. Thromb. Vasc. Biol. | pmid:26966278 |
Daum G et al. | Sphingosine 1-phosphate: a regulator of arterial lesions. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19592471 |
Tölle M et al. | HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production. | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18483405 |
Wamhoff BR et al. | Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18535287 |
Grabski AD et al. | Sphingosine-1-phosphate receptor-2 regulates expression of smooth muscle alpha-actin after arterial injury. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19608972 |
Michaud MD et al. | Sphingosine-1-phosphate: a novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19423865 |
Smyth SS et al. | Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis. | 2014 | Arterioscler. Thromb. Vasc. Biol. | pmid:24482375 |
Kontush A et al. | Preferential sphingosine-1-phosphate enrichment and sphingomyelin depletion are key features of small dense HDL3 particles: relevance to antiapoptotic and antioxidative activities. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17569880 |
Rikitake Y et al. | Involvement of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:11788469 |
Kim YM et al. | G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21212405 |
Yoshida T et al. | Therapeutic angiogenesis by implantation of a capillary structure constituted of human adipose tissue microvascular endothelial cells. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20431071 |
Sorci-Thomas MG and Thomas MJ | High density lipoprotein biogenesis, cholesterol efflux, and immune cell function. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:23077142 |
Frej C et al. | A Shift in ApoM/S1P Between HDL-Particles in Women With Type 1 Diabetes Mellitus Is Associated With Impaired Anti-Inflammatory Effects of the ApoM/S1P Complex. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:28385702 |
Tatematsu S et al. | Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23723371 |
McGuire PG et al. | Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21940944 |
Denimal D et al. | Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Without Diabetes Mellitus to Activate eNOS: Correction by S1P Enrichment. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:28360087 |
Gaengel K et al. | Endothelial-mural cell signaling in vascular development and angiogenesis. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19164813 |
Murohara T | Printing a tissue: a new engineering strategy for cardiovascular regeneration. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20554948 |
Kimura T et al. | High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12775579 |
Shimizu T et al. | Sphingosine-1-phosphate receptor 3 promotes neointimal hyperplasia in mouse iliac-femoral arteries. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22308044 |
Kurano M et al. | Involvement of CETP (Cholesteryl Ester Transfer Protein) in the Shift of Sphingosine-1-Phosphate Among Lipoproteins and in the Modulation of its Functions. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:28126827 |
Hao J et al. | The interaction between C5a and sphingosine-1-phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation. | 2014 | Arthritis Res. Ther. | pmid:25000985 |
Kamradt T and Frey O | Arthritis: where are the T cells? | 2010 | Arthritis Res. Ther. | pmid:20537200 |
Stradner MH et al. | Sphingosine 1-phosphate counteracts the effects of interleukin-1β in human chondrocytes. | 2013 | Arthritis Rheum. | pmid:23666803 |
Kitano M et al. | Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. | 2006 | Arthritis Rheum. | pmid:16508938 |
Callihan P et al. | Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic acid, sphingosine 1-phosphate, and LIF: specific roles for the LPA1 receptor. | 2014 | ASN Neuro | pmid:25424429 |
Togame H et al. | Development of a simple and robust assay to screen for inhibitors of sphingosine kinases. | 2007 | Assay Drug Dev Technol | pmid:17477830 |
Muehlich S et al. | Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets. | 2004 | Atherosclerosis | pmid:15262182 |
Tamama K et al. | High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component. | 2005 | Atherosclerosis | pmid:15585196 |
Zhang B et al. | Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins. | 2005 | Atherosclerosis | pmid:15585219 |
Bosteen MH et al. | Effects of apolipoprotein M in uremic atherosclerosis. | 2017 | Atherosclerosis | pmid:28866363 |
Kurano M et al. | Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M. | 2013 | Atherosclerosis | pmid:23664237 |
Feuerborn R et al. | High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. | 2017 | Atherosclerosis | pmid:28038379 |
Karuna R et al. | Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism. | 2011 | Atherosclerosis | pmid:21944699 |