MeSH term | MeSH ID | Detail |
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Farber Lipogranulomatosis | D055577 | 1 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Miller E et al. | Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. | 2012 | Chem. Biol. | pmid:22884261 |
Pan S et al. | A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. | 2006 | Chem. Biol. | pmid:17114004 |
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Kim ES et al. | A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells. | 2015 | Chem. Biol. Interact. | pmid:25980589 |
Tardieu D et al. | Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. | 2006 | Chem. Biol. Interact. | pmid:16412405 |
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Camp SM et al. | Pulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720. | 2015 | Chem. Phys. Lipids | pmid:26272033 |
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Bedia C et al. | Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity. | 2009 | Chembiochem | pmid:19226506 |
Ullrich T et al. | Synthesis and immobilization of erythro-C14-omega-aminosphingosine-1-phosphate as a potential tool for affinity chromatography. | 2008 | ChemMedChem | pmid:18000941 |
Åukomska A et al. | The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period. | 2017 | Chemosphere | pmid:27697711 |
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Pchejetski D et al. | Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis. | 2007 | Circ. Res. | pmid:17158340 |
Hughes JE et al. | Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. | 2008 | Circ. Res. | pmid:18323526 |
Igarashi J and Michel T | The enigma of sphingosine 1-phosphate synthesis: a novel role for endothelial sphingosine kinases. | 2008 | Circ. Res. | pmid:18369161 |
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Zhao YD et al. | Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1 and Cdc42 signaling. | 2009 | Circ. Res. | pmid:19696411 |
Gazit SL et al. | Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. | 2016 | Circ. Res. | pmid:27582371 |
Xu SZ et al. | A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. | 2006 | Circ. Res. | pmid:16675717 |
Erl W and Siess W | Sphingosine-1-phosphate and the leading Edg-1 of vascular smooth muscle cells. | 2001 | Circ. Res. | pmid:11557732 |
Kluk MJ and Hla T | Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. | 2001 | Circ. Res. | pmid:11557736 |
Maceyka M et al. | Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate. | 2007 | Circ. Res. | pmid:17204658 |
Ramasamy R et al. | Sphingosine-1-phosphate: waging a battle in the diabetic blood vessel. | 2006 | Circ. Res. | pmid:17008596 |
Tanimoto T et al. | Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. | 2004 | Circ. Res. | pmid:15044318 |
Armulik A et al. | Endothelial/pericyte interactions. | 2005 | Circ. Res. | pmid:16166562 |
Birukov KG et al. | Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. | 2004 | Circ. Res. | pmid:15472119 |
Coussin F et al. | Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction. | 2002 | Circ. Res. | pmid:12142348 |
Hla T | Plugging vascular leak by sphingosine kinase from bone marrow progenitor cells. | 2009 | Circ. Res. | pmid:19797192 |
Levkau B | Sphingosine-1-phosphate in the regulation of vascular tone: a finely tuned integration system of S1P sources, receptors, and vascular responsiveness. | 2008 | Circ. Res. | pmid:18669929 |
Ryu Y et al. | Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells. | 2002 | Circ. Res. | pmid:11861422 |
Tawa H et al. | Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis. | 2010 | Circ. Res. | pmid:20413783 |
Fulton D et al. | Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation. Role of eNOS phosphorylation at Tyr83. | 2008 | Circ. Res. | pmid:18096817 |
Whetzel AM et al. | Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. | 2006 | Circ. Res. | pmid:16960101 |
Venkataraman K et al. | Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. | 2008 | Circ. Res. | pmid:18258856 |
Theilmeier G et al. | High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. | 2006 | Circulation | pmid:16982942 |
Jin ZQ et al. | Sphingosine kinase activation mediates ischemic preconditioning in murine heart. | 2004 | Circulation | pmid:15451787 |
Yang J et al. | Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling. | 2012 | Circulation | pmid:22668972 |
Levkau B et al. | High-density lipoprotein stimulates myocardial perfusion in vivo. | 2004 | Circulation | pmid:15545521 |
Nofer JR et al. | FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. | 2007 | Circulation | pmid:17242282 |
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Bolz SS et al. | Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway. | 2003 | Circulation | pmid:12796138 |
Augé N et al. | Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. | 2004 | Circulation | pmid:15277330 |
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