Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with Sphingosine 1-phosphate?
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What lipids are associated with Sphingosine 1-phosphate?
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang W et al. | Sphingosine-1-phosphate receptor-2 mediated NFκB activation contributes to tumor necrosis factor-α induced VCAM-1 and ICAM-1 expression in endothelial cells. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23770055 |
| Cinq-Frais C et al. | A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. | 2013 | Biochim. Biophys. Acta | pmid:23651497 |
| Christoffersen C and Nielsen LB | Apolipoprotein M: bridging HDL and endothelial function. | 2013 | Curr. Opin. Lipidol. | pmid:23652568 |
| Finley A et al. | Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. | 2013 | PLoS ONE | pmid:23372844 |
| Barth BM et al. | Gaucher's disease and cancer: a sphingolipid perspective. | 2013 | Crit Rev Oncog | pmid:23510065 |
| Takuwa Y et al. | Sphingosine-1-phosphate signaling in physiology and diseases. | 2012 Sep-Oct | Biofactors | pmid:22674845 |
| Iwaki S et al. | Posttranscriptional regulation of expression of plasminogen activator inhibitor type-1 by sphingosine 1-phosphate in HepG2 liver cells. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22819712 |
| Fournie P et al. | Sphingosine-1 phosphate prevents ethanol-induced corneal epithelial apoptosis. | 2012 Mar-Apr | Indian J Ophthalmol | pmid:22446906 |
| Tse KW et al. | Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells. | 2012 Jan-Feb | Cell. Immunol. | pmid:22507871 |
| Jin YX et al. | A strategy for enrichment of the bioactive sphingoid base-1-phosphates produced by Hypericum perforatum L. in a balloon type airlift reactor. | 2012 | Bioresour. Technol. | pmid:22940331 |
| Snider AJ et al. | Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22940715 |
| Moon MH et al. | Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes. | 2012 | Int. J. Mol. Med. | pmid:22992945 |
| Park TS and Goldberg IJ | Sphingolipids, lipotoxic cardiomyopathy, and cardiac failure. | 2012 | Heart Fail Clin | pmid:22999245 |
| Ihlefeld K et al. | Evidence for a link between histone deacetylation and Ca²+ homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts. | 2012 | Biochem. J. | pmid:22908849 |
| Wang ZY et al. | [Effect of sphingosine 1-phosphate/sphingosine 1-phosphate receptor signal pathway on function of neutrophils]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22931670 |
| Cannon RE et al. | Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22949658 |
| Richerioux N et al. | Rho-ROCK and Rac-PAK signaling pathways have opposing effects on the cell-to-cell spread of Marek's Disease Virus. | 2012 | PLoS ONE | pmid:22952878 |
| He S et al. | Self-amplification mechanisms of mast cell activation: a new look in allergy. | 2012 | Curr. Mol. Med. | pmid:22920722 |
| Hisano Y et al. | The functional roles of S1P in immunity. | 2012 | J. Biochem. | pmid:22923732 |
| Hisano Y et al. | Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells. | 2012 | PLoS ONE | pmid:22723910 |
| Chiba K and Yoshii N | [Pharmacological properties and clinical efficacy of fingolimod hydrochloride (Imusera®/Gilenya®) for the treatment of multiple sclerosis]. | 2012 | Nippon Yakurigaku Zasshi | pmid:22728990 |
| Linke B et al. | Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22732087 |
| Yokoyama K et al. | Decrease of serum sphingosine-1-phosphate levels in hemodialysis patients with secondary hyperparathyroidism treated with cinacalcet. | 2012 | Clin. Nephrol. | pmid:22732343 |
| Czarnota GJ et al. | Tumor radiation response enhancement by acoustical stimulation of the vasculature. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22778441 |
| Boussommier-Calleja A et al. | Pharmacologic manipulation of conventional outflow facility in ex vivo mouse eyes. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22807298 |
| Kharel Y et al. | Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate. | 2012 | Biochem. J. | pmid:22747486 |
| Sun DF et al. | Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression. | 2012 | Cancer Lett. | pmid:22261335 |
| Zhang BL et al. | Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors. | 2012 | J Zhejiang Univ Sci B | pmid:22761247 |
| Kotelevets N et al. | Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis. | 2012 | PLoS ONE | pmid:22761740 |
| Nakahara T et al. | Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway. | 2012 | Fertil. Steril. | pmid:22763095 |
| Lu H et al. | Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats. | 2012 | Mol. Cell. Biochem. | pmid:22139303 |
| Fujii Y et al. | Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities. | 2012 | J. Immunol. | pmid:22131329 |
| Ishimaru N et al. | CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy. | 2012 | Am. J. Pathol. | pmid:22067914 |
| Lucki NC et al. | Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells. | 2012 | Mol. Cell. Endocrinol. | pmid:21864647 |
| Shi Y et al. | Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. | 2012 | J. Hepatol. | pmid:21756852 |
| Spiegel S et al. | Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy. | 2012 | Oncogene | pmid:21725353 |
| Krishna SM et al. | Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model. | 2012 | Am. J. Pathol. | pmid:22698985 |
| Lee SH et al. | Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humans. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22679064 |
| Ponnusamy S et al. | Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. | 2012 | EMBO Mol Med | pmid:22707406 |
| Kunisawa J and Kiyono H | Immunological function of sphingosine 1-phosphate in the intestine. | 2012 | Nutrients | pmid:22666543 |
| Yang J et al. | Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling. | 2012 | Circulation | pmid:22668972 |
| Li C et al. | Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor. | 2012 | J. Neurophysiol. | pmid:22673325 |
| Watson L et al. | Increased serum concentration of sphingosine-1-phosphate in juvenile-onset systemic lupus erythematosus. | 2012 | J. Clin. Immunol. | pmid:22648459 |
| Sato C et al. | Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22659743 |
| Farahat WA et al. | Ensemble analysis of angiogenic growth in three-dimensional microfluidic cell cultures. | 2012 | PLoS ONE | pmid:22662145 |
| Somers SJ et al. | Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection. | 2012 | Cardiovasc Drugs Ther | pmid:22392184 |
| Chakraborty G et al. | Ethanol triggers sphingosine 1-phosphate elevation along with neuroapoptosis in the developing mouse brain. | 2012 | J. Neurochem. | pmid:22393932 |
| Beech DJ | Integration of transient receptor potential canonical channels with lipids. | 2012 | Acta Physiol (Oxf) | pmid:21624095 |
| Belvitch P and Dudek SM | Role of FAK in S1P-regulated endothelial permeability. | 2012 | Microvasc. Res. | pmid:21925517 |
| Karmouty-Quintana H et al. | Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:22287614 |
| Egom EE | A therapeutic approach to hyperglycaemia in the setting of acute myocardial infarction: spotlight on glucagon-like peptide 1. | 2012 | Ther Adv Cardiovasc Dis | pmid:22902834 |
| Liu Q et al. | Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. | 2012 | PLoS ONE | pmid:22848628 |
| Asghar MY et al. | Sphingosine 1-phosphate and human ether-a'-go-go-related gene potassium channels modulate migration in human anaplastic thyroid cancer cells. | 2012 | Endocr. Relat. Cancer | pmid:22889737 |
| Kim BJ et al. | Plasma sphingosine 1-phosphate levels and the risk of vertebral fracture in postmenopausal women. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22879631 |
| Knapp M et al. | Myocardial infarction changes sphingolipid metabolism in the uninfarcted ventricular wall of the rat. | 2012 | Lipids | pmid:22833182 |
| Beckham TH et al. | Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. | 2012 | Int. J. Cancer | pmid:22322590 |
| Törnquist K | Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells. | 2012 | Acta Physiol (Oxf) | pmid:21338471 |
| Brizuela L et al. | First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer. | 2012 | Mol. Cancer Ther. | pmid:22784711 |
| Salata D et al. | [Sphingosine-1-phosphate--molecular maestro]. | 2012 | Postepy Biochem. | pmid:23373414 |
| Japtok L et al. | Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype. | 2012 | PLoS ONE | pmid:23145172 |
| Härmä V et al. | Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models. | 2012 | Oncogene | pmid:21996742 |
| Zhang L et al. | A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. | 2012 | J. Exp. Med. | pmid:23148237 |
| Qiao Y et al. | Sphingosine 1-phosphate elicits proinflammatory responses in ARPE-19 cells. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:23150617 |
| Mendoza A et al. | The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate. | 2012 | Cell Rep | pmid:23103166 |
| Kurek K et al. | [Role of sphingolipids in digestive system]. | 2012 | Postepy Hig Med Dosw (Online) | pmid:23175343 |
| Bieberich E | It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation. | 2012 | Neurochem. Res. | pmid:22246226 |
| Wilkerson BA et al. | Sphingosine 1-phosphate (S1P) carrier-dependent regulation of endothelial barrier: high density lipoprotein (HDL)-S1P prolongs endothelial barrier enhancement as compared with albumin-S1P via effects on levels, trafficking, and signaling of S1P1. | 2012 | J. Biol. Chem. | pmid:23135269 |
| Giacomini MM et al. | Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force. | 2012 | Exp. Cell Res. | pmid:22309779 |
| Visentin B et al. | Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples. | 2012 | Methods Mol. Biol. | pmid:22528439 |
| Obinata H and Hla T | Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation. | 2012 | Methods Mol. Biol. | pmid:22528440 |
| Medlin MD et al. | Quantifying sphingosine-1-phosphate-dependent activation of the RhoGTPases. | 2012 | Methods Mol. Biol. | pmid:22528442 |
| Belmonte SA and Suhaiman L | Optimized protocols to analyze sphingosine-1-phosphate signal transduction pathways during acrosomal exocytosis in human sperm. | 2012 | Methods Mol. Biol. | pmid:22528443 |
| Ishii T et al. | Use of intravital microscopy and in vitro chemotaxis assays to study the roles of sphingosine-1-phosphate in bone homeostasis. | 2012 | Methods Mol. Biol. | pmid:22528444 |
| Meacci E et al. | Sphingosine-1-phosphate signaling in skeletal muscle cells. | 2012 | Methods Mol. Biol. | pmid:22528446 |
| Yonesu K and Nara F | [Anti-angiogenic effect of bioactive lipid antagonists]. | 2012 | Nippon Rinsho | pmid:23513926 |
| Wong RC et al. | Maintenance of human embryonic stem cells by sphingosine-1-phosphate and platelet-derived growth factor. | 2012 | Methods Mol. Biol. | pmid:22528447 |
| Bieberich E | Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation. | 2012 | Methods Mol. Biol. | pmid:22528448 |
| Callihan P and Hooks SB | Sphingosine-1-phosphate signaling in neural progenitors. | 2012 | Methods Mol. Biol. | pmid:22528449 |
| Su SC and Bayless KJ | Utilizing sphingosine-1-phosphate to stimulate sprouting angiogenesis. | 2012 | Methods Mol. Biol. | pmid:22528450 |
| Lim M et al. | The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries. | 2012 | PLoS ONE | pmid:22532844 |
| Lynch KR | Building a better sphingosine kinase-1 inhibitor. | 2012 | Biochem. J. | pmid:22533672 |
| Mann DL | Sphingosine 1-phosphate as a therapeutic target in heart failure: more questions than answers. | 2012 | Circulation | pmid:22534620 |
| Reina E et al. | Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry. | 2012 | Chem. Phys. Lipids | pmid:22265672 |
| Ding R et al. | Sphingosine-1-phosphate attenuates lung injury induced by intestinal ischemia/reperfusion in mice: role of inducible nitric-oxide synthase. | 2012 | Inflammation | pmid:21302134 |
| Meissner A et al. | Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure. | 2012 | Circulation | pmid:22534621 |
| Christopherson KW | PBSCs Sphingoling along S1P/S1P1 axis. | 2012 | Blood | pmid:22262738 |
| Fujii Y et al. | Lymphopenia induced by a novel selective S1P(1) antagonist structurally unrelated to S1P. | 2012 | Biochim. Biophys. Acta | pmid:22265714 |
| Dakroub Z and Kreydiyyeh SI | Sphingosine-1-phosphate is a mediator of TNF-α action on the Na+/K+ ATPase in HepG2 cells. | 2012 | J. Cell. Biochem. | pmid:22271589 |
| Santulli P et al. | Sphingosine pathway deregulation in endometriotic tissues. | 2012 | Fertil. Steril. | pmid:22277765 |
| Golan K et al. | S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. | 2012 | Blood | pmid:22279055 |
| Jiang H et al. | Application of ultra-performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription. | 2012 | J Sep Sci | pmid:22282408 |
| Takeshita H et al. | Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22326262 |
| Shannon LA et al. | CCR7/CCL19 controls expression of EDG-1 in T cells. | 2012 | J. Biol. Chem. | pmid:22334704 |
| Nunes J et al. | Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection. | 2012 | Br. J. Cancer | pmid:22315056 |
| Shimizu T et al. | Sphingosine-1-phosphate receptor 3 promotes neointimal hyperplasia in mouse iliac-femoral arteries. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22308044 |
| Canals D et al. | Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase. | 2012 | J. Biol. Chem. | pmid:22311981 |
| Knapp M et al. | Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure. | 2012 | Adv Med Sci | pmid:22296975 |
| Nagahashi M et al. | Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. | 2012 | Cancer Res. | pmid:22298596 |
| Ratajczak J et al. | A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient. | 2012 | Leukemia | pmid:22343521 |
| Mascall KS et al. | Sphingosine-1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis. | 2012 | J. Cell. Sci. | pmid:22344262 |