Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Vasta V et al. | Sphingosine 1-phosphate induces arachidonic acid mobilization in A549 human lung adenocarcinoma cells. | 2000 | Biochim. Biophys. Acta | pmid:10601704 |
English D et al. | Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis. | 2000 | FASEB J. | pmid:11053247 |
Shin Y et al. | Diverse effects of sphingosine on calcium mobilization and influx in differentiated HL-60 cells. | 2000 | Cell Calcium | pmid:10859593 |
Himmel HM et al. | Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes. | 2000 | Mol. Pharmacol. | pmid:10908314 |
Driever W | Developmental biology. Bringing two hearts together. | 2000 | Nature | pmid:10910341 |
Kupperman E et al. | A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development. | 2000 | Nature | pmid:10910360 |
Meacci E et al. | Receptor-activated phospholipase D is present in caveolin-3-enriched light membranes of C2C12 myotubes. | 2000 | FEBS Lett. | pmid:10802049 |
Orlati S et al. | Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. | 2000 | Arch. Biochem. Biophys. | pmid:10683250 |
Nanjundan M and Possmayer F | Characterization of the pulmonary N-ethylmaleimide-insensitive phosphatidate phosphohydrolase. | 2000 Jul-Aug | Exp. Lung Res. | pmid:10914334 |
Castillo SS and Teegarden D | Ceramide conversion to sphingosine-1-phosphate is essential for survival in C3H10T1/2 cells. | 2001 | J. Nutr. | pmid:11694603 |
Lyons JM and Karin NJ | A role for G protein-coupled lysophospholipid receptors in sphingolipid-induced Ca2+ signaling in MC3T3-E1 osteoblastic cells. | 2001 | J. Bone Miner. Res. | pmid:11697799 |
Hornuss C et al. | Human and rat alveolar macrophages express multiple EDG receptors. | 2001 | Eur. J. Pharmacol. | pmid:11698050 |
Sullards MC and Merrill AH | Analysis of sphingosine 1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. | 2001 | Sci. STKE | pmid:11752637 |
Kralik SF et al. | A method for quantitative extraction of sphingosine 1-phosphate into organic solvent. | 2001 | Anal. Biochem. | pmid:11444818 |
Wells CD et al. | Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor. | 2001 | J. Biol. Chem. | pmid:11384980 |
Liu F et al. | Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11415936 |
Olorundare OE et al. | Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists. | 2001 | Blood | pmid:11418470 |
Repp H et al. | Activation of a Ca2+-dependent K+ current in mouse fibroblasts by sphingosine-1-phosphate involves the protein tyrosine kinase c-Src. | 2001 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:11284444 |
Ruwisch L et al. | An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials. | 2001 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:11284453 |
Tilly JL | Emerging technologies to control oocyte apoptosis are finally treading on fertile ground. | 2001 | ScientificWorldJournal | pmid:12805661 |