Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Osawa Y et al. | TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. | 2001 | J. Immunol. | pmid:11418646 |
Boujaoude LC et al. | Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. | 2001 | J. Biol. Chem. | pmid:11443135 |
Paik JH et al. | Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. | 2001 | J. Biol. Chem. | pmid:11150298 |
Meyer zu Heringdorf D et al. | Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. | 2001 | Eur. J. Pharmacol. | pmid:11239914 |
Young KW and Nahorski SR | Intracellular sphingosine 1-phosphate production: a novel pathway for Ca2+ release. | 2001 | Semin. Cell Dev. Biol. | pmid:11162743 |
English D et al. | Platelet-released phospholipids link haemostasis and angiogenesis. | 2001 | Cardiovasc. Res. | pmid:11166272 |
Radin NS | Killing cancer cells by poly-drug elevation of ceramide levels: a hypothesis whose time has come? | 2001 | Eur. J. Biochem. | pmid:11168352 |
Karliner JS et al. | The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes. | 2001 | J. Mol. Cell. Cardiol. | pmid:11549349 |
Siehler S et al. | Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells. | 2001 | J. Biol. Chem. | pmid:11673450 |
Brownlee C | Intracellular signalling: sphingosine-1-phosphate branches out. | 2001 | Curr. Biol. | pmid:11470429 |
Igarashi J and Michel T | Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways. | 2001 | J. Biol. Chem. | pmid:11470796 |
Garcia JG et al. | Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. | 2001 | J. Clin. Invest. | pmid:11544274 |
Nadal A et al. | Glial cell responses to lipids bound to albumin in serum and plasma. | 2001 | Prog. Brain Res. | pmid:11545003 |
Panetti TS et al. | Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324710 |
Alderton F et al. | G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells. | 2001 | J. Biol. Chem. | pmid:11278307 |
Igarashi J et al. | Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. | 2001 | J. Biol. Chem. | pmid:11278407 |
Morales-Ruiz M et al. | Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. | 2001 | J. Biol. Chem. | pmid:11278592 |
Birchwood CJ et al. | Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation. | 2001 | J. Biol. Chem. | pmid:11278643 |
Ng CK et al. | Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. | 2001 | Nature | pmid:11279499 |
Kranenburg O and Moolenaar WH | Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. | 2001 | Oncogene | pmid:11313900 |
Schwartz BM et al. | Lysophospholipids increase interleukin-8 expression in ovarian cancer cells. | 2001 | Gynecol. Oncol. | pmid:11330965 |
Hobson JP et al. | Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. | 2001 | Science | pmid:11230698 |
Alderton F et al. | Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells. | 2001 | J. Biol. Chem. | pmid:11359779 |
Pébay A et al. | Antiproliferative properties of sphingosine-1-phosphate in human hepatic myofibroblasts. | 2001 | Eur. J. Neurosci. | pmid:11422447 |
Osawa Y et al. | Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11520048 |
Banno Y et al. | Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3. | 2001 | J. Biol. Chem. | pmid:11468290 |
Blaukat A and Dikic I | Activation of sphingosine kinase by the bradykinin B2 receptor and its implication in regulation of the ERK/MAP kinase pathway. | 2001 | Biol. Chem. | pmid:11258664 |
Nanjundan M and Possmayer F | Characterization of the pulmonary N-ethylmaleimide-insensitive phosphatidate phosphohydrolase. | 2000 Jul-Aug | Exp. Lung Res. | pmid:10914334 |
Pyne S and Pyne NJ | Sphingosine 1-phosphate signalling in mammalian cells. | 2000 | Biochem. J. | pmid:10880336 |
Sharma C et al. | Inhibition of Ca2+ release channel (ryanodine receptor) activity by sphingolipid bases: mechanism of action. | 2000 | Chem. Phys. Lipids | pmid:10660207 |
Vasta V et al. | Sphingosine 1-phosphate induces arachidonic acid mobilization in A549 human lung adenocarcinoma cells. | 2000 | Biochim. Biophys. Acta | pmid:10601704 |
An S et al. | Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. | 2000 | J. Biol. Chem. | pmid:10617617 |
Pyne S and Pyne N | Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors. | 2000 | Pharmacol. Ther. | pmid:11150592 |
Conway A et al. | Ceramide-dependent regulation of p42/p44 mitogen-activated protein kinase and c-Jun N-terminal-directed protein kinase in cultured airway smooth muscle cells. | 2000 | Cell. Signal. | pmid:11152959 |
Olivera A et al. | Assaying sphingosine kinase activity. | 2000 | Meth. Enzymol. | pmid:10563328 |
Brindley DN et al. | Analysis of ceramide 1-phosphate and sphingosine-1-phosphate phosphatase activities. | 2000 | Meth. Enzymol. | pmid:10563330 |
Rümenapp U et al. | Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility. | 2000 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:10651140 |
Lee OH et al. | Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10652210 |
Hla T et al. | Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818438 |
Spiegel S | Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818441 |
Ancellin N and Hla T | Switching intracellular signaling pathways to study sphingosine 1-phosphate receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818459 |
Yamamura S et al. | Sphingosine-1-phosphate inhibits haptotactic motility by overproduction of focal adhesion sites in B16 melanoma cells through EDG-induced activation of Rho. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818470 |
Gallois C et al. | Endothelin-1 stimulates sphingosine kinase in human hepatic stellate cells. A novel role for sphingosine-1-P as a mediator of growth inhibition. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818472 |
Gennero I et al. | Effect of sphingosine-1-phosphate and analogues of lysophosphatidic acid on mesangial cell proliferation. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818478 |
Alessenko AV | The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death. | 2000 | Membr Cell Biol | pmid:10779176 |
Miura Y et al. | Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets. | 2000 | J. Biochem. | pmid:10788802 |
Im DS et al. | Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. | 2000 | J. Biol. Chem. | pmid:10799507 |
Goetzl EJ et al. | Cutting edge: differential constitutive expression of functional receptors for lysophosphatidic acid by human blood lymphocytes. | 2000 | J. Immunol. | pmid:10799850 |
Nava VE et al. | Functional characterization of human sphingosine kinase-1. | 2000 | FEBS Lett. | pmid:10802064 |
Spiegel S and Milstien S | Functions of a new family of sphingosine-1-phosphate receptors. | 2000 | Biochim. Biophys. Acta | pmid:10760461 |
Panetti TS et al. | Sphingosine-1-phosphate and lysophosphatidic acid stimulate endothelial cell migration. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10764666 |
Boguslawski G et al. | Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833459 |
Edsall L et al. | Enzymatic method for measurement of sphingosine 1-phosphate. | 2000 | Meth. Enzymol. | pmid:11070858 |
Sullards MC | Analysis of sphingomyelin, glucosylceramide, ceramide, sphingosine, and sphingosine 1-phosphate by tandem mass spectrometry. | 2000 | Meth. Enzymol. | pmid:11070861 |
Van Brocklyn JR and Spiegel S | Binding of sphingosine 1-phosphate to cell surface receptors. | 2000 | Meth. Enzymol. | pmid:11070888 |
Yatomi Y et al. | Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells. | 2000 | Blood | pmid:11071638 |
Fukushima N | [A family of lysophospholipid receptors]. | 2000 | Seikagaku | pmid:11076202 |
Meacci E et al. | Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts. | 2000 | FEBS Lett. | pmid:11018530 |
Kozawa O et al. | Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase. | 2000 | J. Cell. Biochem. | pmid:11029753 |
Sato TN | A new role of lipid receptors in vascular and cardiac morphogenesis. | 2000 | J. Clin. Invest. | pmid:11032853 |
Liu Y et al. | Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. | 2000 | J. Clin. Invest. | pmid:11032855 |
Xia P et al. | An oncogenic role of sphingosine kinase. | 2000 | Curr. Biol. | pmid:11114522 |
Okamoto H et al. | Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. | 2000 | Mol. Cell. Biol. | pmid:11094076 |
Murata N et al. | Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions. | 2000 | Biochem. J. | pmid:11104690 |
Shimizu H et al. | Sphingosine 1-phosphate stimulates insulin secretion in HIT-T 15 cells and mouse islets. | 2000 | Endocr. J. | pmid:11036869 |
MacLennan AJ et al. | Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell-cell interaction and neurite outgrowth. | 2000 | Dev. Neurosci. | pmid:10965150 |
Nakajima N et al. | Expression and characterization of Edg-1 receptors in rat cardiomyocytes: calcium deregulation in response to sphingosine 1-phosphate. | 2000 | Eur. J. Biochem. | pmid:10971577 |
Parrill AL et al. | Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate. | 2000 | J. Biol. Chem. | pmid:10982820 |
Davaille J et al. | Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway. | 2000 | J. Biol. Chem. | pmid:10942778 |
Pitson SM et al. | Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase. | 2000 | J. Biol. Chem. | pmid:10944534 |
Nugent D and Xu Y | Sphingosine-1-phosphate: characterization of its inhibition of platelet aggregation. | 2000 | Platelets | pmid:10938902 |
Young KW et al. | Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells. | 2000 | Eur. J. Pharmacol. | pmid:10940357 |
Bischoff A et al. | Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. | 2000 | Br. J. Pharmacol. | pmid:10952677 |
Bischoff A et al. | Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner. | 2000 | Br. J. Pharmacol. | pmid:10952678 |
Shin Y et al. | Diverse effects of sphingosine on calcium mobilization and influx in differentiated HL-60 cells. | 2000 | Cell Calcium | pmid:10859593 |
Alemany R et al. | Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptor-mediated Ca(2+) mobilization, but not MAP kinase activation. | 2000 | Mol. Pharmacol. | pmid:10953041 |
Young KW et al. | Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors. | 2000 | J. Biol. Chem. | pmid:10954727 |
Peyruchaud O and Mosher DF | Differential stimulation of signaling pathways initiated by Edg-2 in response to lysophosphatidic acid or sphingosine-1-phosphate. | 2000 | Cell. Mol. Life Sci. | pmid:10961347 |
Casper RF and Jurisicova A | Protecting the female germ line from cancer therapy. | 2000 | Nat. Med. | pmid:11017136 |
Driever W | Developmental biology. Bringing two hearts together. | 2000 | Nature | pmid:10910341 |
Kupperman E et al. | A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development. | 2000 | Nature | pmid:10910360 |
Mandala SM et al. | Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10859351 |
Meacci E et al. | Receptor-activated phospholipase D is present in caveolin-3-enriched light membranes of C2C12 myotubes. | 2000 | FEBS Lett. | pmid:10802049 |
Murata N et al. | Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay. | 2000 | Anal. Biochem. | pmid:10860507 |
Siess W et al. | Lysophosphatidic acid and sphingosine 1-phosphate: two lipid villains provoking cardiovascular diseases? | 2000 | IUBMB Life | pmid:10868905 |
Caligan TB et al. | A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples. | 2000 | Anal. Biochem. | pmid:10847608 |
Igarashi J and Michel T | Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. | 2000 | J. Biol. Chem. | pmid:10921915 |
Racké K et al. | Potential role of EDG receptors and lysophospholipids as their endogenous ligands in the respiratory tract. | 2000 | Pulm Pharmacol Ther | pmid:10873548 |
Sugiyama A et al. | Effects of sphingosine 1-phosphate, a naturally occurring biologically active lysophospholipid, on the rat cardiovascular system. | 2000 | Jpn. J. Pharmacol. | pmid:10875754 |
Spiegel S and Milstien S | Sphingosine-1-phosphate: signaling inside and out. | 2000 | FEBS Lett. | pmid:10878250 |
Cooke ME et al. | Contraction of collagen matrices mediated by alpha2beta1A and alpha(v)beta3 integrins. | 2000 | J. Cell. Sci. | pmid:10852817 |
Yanai N et al. | Sphingosine-1-phosphate and lysophosphatidic acid trigger invasion of primitive hematopoietic cells into stromal cell layers. | 2000 | Blood | pmid:10891442 |
Prieschl EE and Baumruker T | Beyond a structural component: sphingolipids in immunology. | 2000 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:10912620 |
Ikeda H et al. | Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10915638 |
Yamazaki Y et al. | Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679247 |
Lee H et al. | Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10712250 |
Kim JH et al. | Sphingosine 1-phosphate activates Erk-1/-2 by transactivating epidermal growth factor receptor in rat-2 cells. | 2000 | IUBMB Life | pmid:11185956 |
Motohashi K et al. | Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1-phosphate. | 2000 | FEBS Lett. | pmid:10692584 |
Sugiyama A et al. | Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart. | 2000 | Cardiovasc. Res. | pmid:10727660 |
Orlati S et al. | Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. | 2000 | Arch. Biochem. Biophys. | pmid:10683250 |