De Luca T et al. |
NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis. |
2005 |
Biofactors |
pmid:16873929
|
Stahelin RV et al. |
The mechanism of membrane targeting of human sphingosine kinase 1. |
2005 |
J. Biol. Chem. |
pmid:16243846
|
Perez GI et al. |
A central role for ceramide in the age-related acceleration of apoptosis in the female germline. |
2005 |
FASEB J. |
pmid:15728664
|
Lindner K et al. |
Ceramide alters endothelial cell permeability by a nonapoptotic mechanism. |
2005 |
Br. J. Pharmacol. |
pmid:15735657
|
Ikeda M et al. |
Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme. |
2005 |
Biochem. Biophys. Res. Commun. |
pmid:15737611
|
Yabu T et al. |
Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate. |
2005 |
Blood |
pmid:15741222
|
Kee TH et al. |
Sphingosine kinase signalling in immune cells. |
2005 |
Clin. Exp. Pharmacol. Physiol. |
pmid:15743396
|
Suomalainen L et al. |
Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors. |
2005 |
Am. J. Pathol. |
pmid:15743789
|
Pilorget A et al. |
Inhibition of angiogenic properties of brain endothelial cells by platelet-derived sphingosine-1-phosphate. |
2005 |
J. Cereb. Blood Flow Metab. |
pmid:15829917
|
Bolick DT et al. |
Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. |
2005 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:15761190
|
Blom T et al. |
Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response. |
2005 |
Cell. Signal. |
pmid:15763425
|
Im YJ et al. |
Study on action mode of sphingosine 1-phosphate in rat hepatocytes. |
2005 |
J. Pharmacol. Sci. |
pmid:15764837
|
Oberst MD et al. |
HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease. |
2005 |
Am. J. Physiol., Cell Physiol. |
pmid:15800053
|
Davis MD et al. |
Sphingosine 1-phosphate analogs as receptor antagonists. |
2005 |
J. Biol. Chem. |
pmid:15590668
|
Lee MS et al. |
Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells. |
2005 |
Am. J. Physiol., Cell Physiol. |
pmid:15590895
|
Watterson KR et al. |
The role of sphingosine-1-phosphate in smooth muscle contraction. |
2005 |
Cell. Signal. |
pmid:15567060
|
Donati C et al. |
Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor. |
2005 |
FASEB J. |
pmid:15625079
|
Damirin A et al. |
Sphingosine 1-phosphate receptors mediate the lipid-induced cAMP accumulation through cyclooxygenase-2/prostaglandin I2 pathway in human coronary artery smooth muscle cells. |
2005 |
Mol. Pharmacol. |
pmid:15625281
|
Urata Y et al. |
Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase. |
2005 |
Kobe J Med Sci |
pmid:16199931
|
Vessey DA et al. |
A rapid radioassay for sphingosine kinase. |
2005 |
Anal. Biochem. |
pmid:15649386
|
Hughes SK et al. |
Fluid shear stress modulates cell migration induced by sphingosine 1-phosphate and vascular endothelial growth factor. |
2005 |
Ann Biomed Eng |
pmid:16133909
|
Foss FW et al. |
Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. |
2005 |
Bioorg. Med. Chem. Lett. |
pmid:16125386
|
van Meeteren LA et al. |
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. |
2005 |
J. Biol. Chem. |
pmid:15769751
|
Tani M et al. |
Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu. |
2005 |
J. Biol. Chem. |
pmid:16126722
|
Huang WR et al. |
[Effects of sphingosine 1-phosphate on functions of T cell - review]. |
2005 |
Zhongguo Shi Yan Xue Ye Xue Za Zhi |
pmid:16129068
|
Saini HS et al. |
Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. |
2005 |
J. Neurochem. |
pmid:16313513
|
Mizugishi K et al. |
Essential role for sphingosine kinases in neural and vascular development. |
2005 |
Mol. Cell. Biol. |
pmid:16314531
|
Katkade V et al. |
Domain 5 of cleaved high molecular weight kininogen inhibits endothelial cell migration through Akt. |
2005 |
Thromb. Haemost. |
pmid:16268479
|
Wei SH et al. |
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. |
2005 |
Nat. Immunol. |
pmid:16273098
|
Lee HS et al. |
Antigen-induced Ca2+ mobilization in RBL-2H3 cells: role of I(1,4,5)P3 and S1P and necessity of I(1,4,5)P3 production. |
2005 |
Cell Calcium |
pmid:16219349
|
Chalfant CE and Spiegel S |
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. |
2005 |
J. Cell. Sci. |
pmid:16219683
|
Armulik A et al. |
Endothelial/pericyte interactions. |
2005 |
Circ. Res. |
pmid:16166562
|
Pchejetski D et al. |
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models. |
2005 |
Cancer Res. |
pmid:16357178
|
Itagaki K et al. |
Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils. |
2005 |
J. Leukoc. Biol. |
pmid:15522918
|
McVerry BJ and Garcia JG |
In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. |
2005 |
Cell. Signal. |
pmid:15494205
|
Waters CM et al. |
c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. |
2005 |
Cell. Signal. |
pmid:15494217
|
Maceyka M et al. |
Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. |
2005 |
Prostaglandins Other Lipid Mediat. |
pmid:16099387
|
Danieli-Betto D et al. |
Sphingosine 1-phosphate protects mouse extensor digitorum longus skeletal muscle during fatigue. |
2005 |
Am. J. Physiol., Cell Physiol. |
pmid:15659717
|
Roth Z and Hansen PJ |
Disruption of nuclear maturation and rearrangement of cytoskeletal elements in bovine oocytes exposed to heat shock during maturation. |
2005 |
Reproduction |
pmid:15695618
|
Tanski WJ et al. |
Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin. |
2005 |
J. Vasc. Surg. |
pmid:15696050
|
Björklund S et al. |
Effects of sphingosine 1-phosphate on calcium signaling, proliferation and S1P2 receptor expression in PC Cl3 rat thyroid cells. |
2005 |
Mol. Cell. Endocrinol. |
pmid:15713536
|
Anelli V et al. |
Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes. |
2005 |
J. Neurochem. |
pmid:15715670
|
Mehta D et al. |
Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells. |
2005 |
J. Biol. Chem. |
pmid:15728185
|
Chun J |
Lysophospholipids in the nervous system. |
2005 |
Prostaglandins Other Lipid Mediat. |
pmid:16099390
|
Formigli L et al. |
Sphingosine 1-phosphate induces cytoskeletal reorganization in C2C12 myoblasts: physiological relevance for stress fibres in the modulation of ion current through stretch-activated channels. |
2005 |
J. Cell. Sci. |
pmid:15728255
|
Rosen H |
Chemical approaches to the lysophospholipid receptors. |
2005 |
Prostaglandins Other Lipid Mediat. |
pmid:16099402
|
Minnear FL et al. |
Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. |
2005 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:15778280
|
Inagaki Y et al. |
Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors. |
2005 |
Biochem. J. |
pmid:15733055
|
Ohmori T et al. |
The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca2+ mobilization in platelets. |
2005 |
Thromb. Res. |
pmid:15733975
|
Hsiao SH et al. |
Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings. |
2005 |
Toxicol. Sci. |
pmid:15829618
|
Murakami T et al. |
Synthesis and biological properties of novel sphingosine derivatives. |
2005 |
Bioorg. Med. Chem. Lett. |
pmid:15686924
|
Edsbagge J et al. |
Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. |
2005 |
Development |
pmid:15689381
|
Jaillard C et al. |
Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival. |
2005 |
J. Neurosci. |
pmid:15703400
|
Geoffroy K et al. |
Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels. |
2005 |
FEBS Lett. |
pmid:15710421
|
Duan HF et al. |
[Establishment of a method for determining the sphingosine kinase activity and its initial application]. |
2005 |
Zhongguo Ying Yong Sheng Li Xue Za Zhi |
pmid:21180179
|
Takashiro Y et al. |
Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells. |
2005 |
Biochem. Pharmacol. |
pmid:15907808
|
Halin C et al. |
The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. |
2005 |
Blood |
pmid:15870184
|
Takeshita A et al. |
Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells. |
2005 |
J Oral Sci |
pmid:15881228
|
Sauer B et al. |
Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat. |
2005 |
Pharmazie |
pmid:15881612
|
Ma Y et al. |
Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. |
2005 |
J. Biol. Chem. |
pmid:15883165
|
Radeke HH et al. |
Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52. |
2005 |
J. Immunol. |
pmid:15728487
|
Kim JW et al. |
Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases. |
2005 |
Bioorg. Med. Chem. |
pmid:15848761
|
Tani M et al. |
Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. |
2005 |
J. Lipid Res. |
pmid:16061940
|
Kawata T et al. |
Sphingosine 1-phosphate inhibits migration and RANTES production in human bronchial smooth muscle cells. |
2005 |
Biochem. Biophys. Res. Commun. |
pmid:15850807
|
Pfaff M et al. |
Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. |
2005 |
Respir. Res. |
pmid:15927078
|
Rosen H and Goetzl EJ |
Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. |
2005 |
Nat. Rev. Immunol. |
pmid:15999095
|
Yin F and Watsky MA |
LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance. |
2005 |
Invest. Ophthalmol. Vis. Sci. |
pmid:15914605
|
Karliner JS |
Off the shelf but not mass produced. |
2005 |
Chem. Biol. |
pmid:15975506
|
Jo E et al. |
S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. |
2005 |
Chem. Biol. |
pmid:15975516
|
Li Z et al. |
Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. |
2005 |
Prostaglandins Other Lipid Mediat. |
pmid:15967165
|
Ledent C et al. |
Premature ovarian aging in mice deficient for Gpr3. |
2005 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:15956199
|
Wu WT et al. |
Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells. |
2005 |
Endocrinology |
pmid:15878967
|
Kariya Y et al. |
Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis. |
2005 |
Genes Cells |
pmid:15938718
|
Abbey-Hosch SE et al. |
Differential regulation of NPR-B/GC-B by protein kinase c and calcium. |
2005 |
Biochem. Pharmacol. |
pmid:16005434
|
Osawa Y et al. |
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. |
2005 |
J. Biol. Chem. |
pmid:15946935
|
Clemens JJ et al. |
Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. |
2005 |
Bioorg. Med. Chem. Lett. |
pmid:15982878
|
Zaslavsky A et al. |
Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells. |
2005 |
FEBS Lett. |
pmid:15987639
|
Chae SS and Hla T |
Inhibition of gene expression in vivo using multiplex siRNA. |
2005 |
Methods Mol. Biol. |
pmid:15990401
|
Berdyshev EV et al. |
Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. |
2005 |
Anal. Biochem. |
pmid:15766719
|
Long J et al. |
Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. |
2005 |
Biochem. J. |
pmid:15960610
|
Malchinkhuu E et al. |
Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells. |
2005 |
Oncogene |
pmid:16007180
|
Pébay A et al. |
Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells. |
2005 Nov-Dec |
Stem Cells |
pmid:16081668
|
Seol GH et al. |
Sphingosine-1-phosphate-induced intracellular Ca2+ mobilization in human endothelial cells. |
2005 Sep-Dec |
Endothelium |
pmid:16410226
|
Leclercq TM and Pitson SM |
Cellular signalling by sphingosine kinase and sphingosine 1-phosphate. |
2006 |
IUBMB Life |
pmid:16916784
|
Kohno M et al. |
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. |
2006 |
Mol. Cell. Biol. |
pmid:16980623
|
Theilmeier G et al. |
High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. |
2006 |
Circulation |
pmid:16982942
|
Murph M et al. |
Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer. |
2006 |
Clin. Cancer Res. |
pmid:17121877
|
Fisher KE et al. |
Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling. |
2006 |
Mol. Cancer |
pmid:17156449
|
Betito S and Cuvillier O |
Regulation by sphingosine 1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner. |
2006 |
Biochem. Biophys. Res. Commun. |
pmid:16414356
|
Lee JF et al. |
Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. |
2006 |
Histochem. Cell Biol. |
pmid:16416022
|
Taha TA et al. |
Sphingosine kinase: biochemical and cellular regulation and role in disease. |
2006 |
J. Biochem. Mol. Biol. |
pmid:16584625
|
Hu W et al. |
Lentiviral siRNA silencing of sphingosine-1-phosphate receptors S1P1 and S1P2 in smooth muscle. |
2006 |
Biochem. Biophys. Res. Commun. |
pmid:16574065
|
Zhi L et al. |
Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFalpha in primary human monocytes. |
2006 |
J. Cell. Physiol. |
pmid:16575915
|
Wacker BK et al. |
Delivery of sphingosine 1-phosphate from poly(ethylene glycol) hydrogels. |
2006 |
Biomacromolecules |
pmid:16602758
|
Der P et al. |
Role of lipid rafts in ceramide and nitric oxide signaling in the ischemic and preconditioned hearts. |
2006 |
J. Mol. Cell. Cardiol. |
pmid:16337960
|
Gonzalez E et al. |
Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells. |
2006 |
J. Biol. Chem. |
pmid:16339142
|
Huang WR et al. |
[Impact of rhG-CSF on sphingosine 1-phosphate concentration in blood plasma of donors]. |
2006 |
Zhongguo Shi Yan Xue Ye Xue Za Zhi |
pmid:16928321
|
Meriane M et al. |
Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells. |
2006 |
Stem Cells |
pmid:16931773
|
Bjursell M et al. |
G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice. |
2006 |
Biochem. Biophys. Res. Commun. |
pmid:16887097
|
Donati C and Bruni P |
Sphingosine 1-phosphate regulates cytoskeleton dynamics: implications in its biological response. |
2006 |
Biochim. Biophys. Acta |
pmid:16890187
|