| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Angiopathies | D003925 | 20 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Dilatation, Pathologic | D004108 | 5 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Eye Abnormalities | D005124 | 7 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pyne S and Pyne NJ | Sphingosine 1-phosphate signalling in mammalian cells. | 2000 | Biochem. J. | pmid:10880336 |
| Sharma C et al. | Inhibition of Ca2+ release channel (ryanodine receptor) activity by sphingolipid bases: mechanism of action. | 2000 | Chem. Phys. Lipids | pmid:10660207 |
| Olivera A et al. | Assaying sphingosine kinase activity. | 2000 | Meth. Enzymol. | pmid:10563328 |
| Brindley DN et al. | Analysis of ceramide 1-phosphate and sphingosine-1-phosphate phosphatase activities. | 2000 | Meth. Enzymol. | pmid:10563330 |
| Rümenapp U et al. | Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility. | 2000 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:10651140 |
| Lee OH et al. | Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10652210 |
| Sato K et al. | Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells. | 2000 | Brain Res. Mol. Brain Res. | pmid:11146117 |
| Hla T et al. | Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818438 |
| Spiegel S | Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818441 |
| Ancellin N and Hla T | Switching intracellular signaling pathways to study sphingosine 1-phosphate receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818459 |
| Yamamura S et al. | Sphingosine-1-phosphate inhibits haptotactic motility by overproduction of focal adhesion sites in B16 melanoma cells through EDG-induced activation of Rho. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818470 |
| Gallois C et al. | Endothelin-1 stimulates sphingosine kinase in human hepatic stellate cells. A novel role for sphingosine-1-P as a mediator of growth inhibition. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818472 |
| Gennero I et al. | Effect of sphingosine-1-phosphate and analogues of lysophosphatidic acid on mesangial cell proliferation. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818478 |
| Alessenko AV | The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death. | 2000 | Membr Cell Biol | pmid:10779176 |
| Miura Y et al. | Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets. | 2000 | J. Biochem. | pmid:10788802 |
| Im DS et al. | Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. | 2000 | J. Biol. Chem. | pmid:10799507 |
| Fukushima N | [A family of lysophospholipid receptors]. | 2000 | Seikagaku | pmid:11076202 |
| Meacci E et al. | Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts. | 2000 | FEBS Lett. | pmid:11018530 |
| Kozawa O et al. | Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase. | 2000 | J. Cell. Biochem. | pmid:11029753 |
| Sato TN | A new role of lipid receptors in vascular and cardiac morphogenesis. | 2000 | J. Clin. Invest. | pmid:11032853 |
| Liu Y et al. | Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. | 2000 | J. Clin. Invest. | pmid:11032855 |
| Xia P et al. | An oncogenic role of sphingosine kinase. | 2000 | Curr. Biol. | pmid:11114522 |
| Okamoto H et al. | Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. | 2000 | Mol. Cell. Biol. | pmid:11094076 |
| Murata N et al. | Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions. | 2000 | Biochem. J. | pmid:11104690 |
| Shimizu H et al. | Sphingosine 1-phosphate stimulates insulin secretion in HIT-T 15 cells and mouse islets. | 2000 | Endocr. J. | pmid:11036869 |
| MacLennan AJ et al. | Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell-cell interaction and neurite outgrowth. | 2000 | Dev. Neurosci. | pmid:10965150 |
| Nakajima N et al. | Expression and characterization of Edg-1 receptors in rat cardiomyocytes: calcium deregulation in response to sphingosine 1-phosphate. | 2000 | Eur. J. Biochem. | pmid:10971577 |
| Parrill AL et al. | Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate. | 2000 | J. Biol. Chem. | pmid:10982820 |
| Davaille J et al. | Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway. | 2000 | J. Biol. Chem. | pmid:10942778 |
| Pitson SM et al. | Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase. | 2000 | J. Biol. Chem. | pmid:10944534 |
| Nugent D and Xu Y | Sphingosine-1-phosphate: characterization of its inhibition of platelet aggregation. | 2000 | Platelets | pmid:10938902 |
| Young KW et al. | Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells. | 2000 | Eur. J. Pharmacol. | pmid:10940357 |
| Bischoff A et al. | Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. | 2000 | Br. J. Pharmacol. | pmid:10952677 |
| Shin Y et al. | Diverse effects of sphingosine on calcium mobilization and influx in differentiated HL-60 cells. | 2000 | Cell Calcium | pmid:10859593 |
| Meacci E et al. | Receptor-activated phospholipase D is present in caveolin-3-enriched light membranes of C2C12 myotubes. | 2000 | FEBS Lett. | pmid:10802049 |
| Racké K et al. | Potential role of EDG receptors and lysophospholipids as their endogenous ligands in the respiratory tract. | 2000 | Pulm Pharmacol Ther | pmid:10873548 |
| Sugiyama A et al. | Effects of sphingosine 1-phosphate, a naturally occurring biologically active lysophospholipid, on the rat cardiovascular system. | 2000 | Jpn. J. Pharmacol. | pmid:10875754 |
| Spiegel S and Milstien S | Sphingosine-1-phosphate: signaling inside and out. | 2000 | FEBS Lett. | pmid:10878250 |
| Cooke ME et al. | Contraction of collagen matrices mediated by alpha2beta1A and alpha(v)beta3 integrins. | 2000 | J. Cell. Sci. | pmid:10852817 |
| Yanai N et al. | Sphingosine-1-phosphate and lysophosphatidic acid trigger invasion of primitive hematopoietic cells into stromal cell layers. | 2000 | Blood | pmid:10891442 |
| Prieschl EE and Baumruker T | Beyond a structural component: sphingolipids in immunology. | 2000 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:10912620 |
| Ikeda H et al. | Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10915638 |
| Yamazaki Y et al. | Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679247 |
| Lee H et al. | Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10712250 |
| Motohashi K et al. | Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1-phosphate. | 2000 | FEBS Lett. | pmid:10692584 |
| Sugiyama A et al. | Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart. | 2000 | Cardiovasc. Res. | pmid:10727660 |
| Kozawa O et al. | Sphingosine 1-phosphate amplifies phosphoinositide hydrolysis stimulated by prostaglandin f2 alpha in osteoblasts: involvement of p38MAP kinase. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913228 |
| Orlati S et al. | Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. | 2000 | Arch. Biochem. Biophys. | pmid:10683250 |
| Okamoto H et al. | Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration. | 2000 | Thromb. Res. | pmid:10942792 |
| Takeshita A et al. | Selective stimulation by ceramide of the expression of the alpha isoform of retinoic acid and retinoid X receptors in osteoblastic cells. A role of sphingosine 1-phosphate-mediated AP-1 in the ligand-dependent transcriptional activity of these receptors. | 2000 | J. Biol. Chem. | pmid:10915783 |