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Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro. |
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Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival. |
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Cell. Signal. |
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Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. |
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Neurology |
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Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. |
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Nature |
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Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases. |
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Neuropharmacology |
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Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. |
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PLoS ONE |
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Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. |
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Annu. Rev. Physiol. |
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Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720. |
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Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells. |
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Biofactors |
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Sphingosine 1-Phosphate Signaling and Its Pharmacological Modulation in Allogeneic Hematopoietic Stem Cell Transplantation. |
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Int J Mol Sci |
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Eur. J. Pharmacol. |
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Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. |
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"Dicing and Splicing" Sphingosine Kinase and Relevance to Cancer. |
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Int J Mol Sci |
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Effects of apolipoprotein M in uremic atherosclerosis. |
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Atherosclerosis |
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Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation. |
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Mediators Inflamm. |
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Determination of Sphingosine-1-Phosphate in Human Plasma Using Liquid Chromatography Coupled with Q-Tof Mass Spectrometry. |
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An engineered S1P chaperone attenuates hypertension and ischemic injury. |
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Sci Signal |
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Mediators Inflamm. |
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Acid ceramidase confers radioresistance to glioblastoma cells. |
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In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome. |
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Sphingosine-1-phosphate is involved in inflammatory reactions in patients with Graves' orbitopathy. |
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Cell. Signal. |
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Sphingosine-1-phosphate activates the AKT pathway to inhibit chemotherapy induced human granulosa cell apoptosis. |
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Gynecol. Endocrinol. |
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The Utility of Biomarkers in Osteoporosis Management. |
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Mol Diagn Ther |
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Endothelial glycocalyx as a critical signalling platform integrating the extracellular haemodynamic forces and chemical signalling. |
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Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications. |
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Clin. Chim. Acta |
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High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. |
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Atherosclerosis |
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Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices. |
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PLoS ONE |
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Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. |
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PLoS ONE |
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Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication. |
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PLoS ONE |
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Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. |
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Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma. |
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A Shift in ApoM/S1P Between HDL-Particles in Women With Type 1 Diabetes Mellitus Is Associated With Impaired Anti-Inflammatory Effects of the ApoM/S1P Complex. |
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The role of sphingosine-1-phosphate in the tumor microenvironment and its clinical implications. |
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J. Cell. Physiol. |
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Ageing adversely affects the migration and function of marginal zone B cells. |
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Immunology |
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Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration. |
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Biomed Res Int |
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Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. |
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Gastroenterology |
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Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease. |
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Int J Mol Sci |
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Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Without Diabetes Mellitus to Activate eNOS: Correction by S1P Enrichment. |
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Evaluation and Optimization of designed Sphingosine-1-Phosphate (S1P) Receptor Subtype 1 Modulators for the Management of Multiple Sclerosis. |
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Yale J Biol Med |
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Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. |
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Sci Signal |
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Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. |
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PLoS ONE |
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The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. |
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Hepatology |
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C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure. |
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World J. Gastroenterol. |
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Involvement of Sphingosine 1-Phosphate in Palmitate-Induced Non-Alcoholic Fatty Liver Disease. |
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Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism. |
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PLoS ONE |
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FTY720P inhibits hepatic Na(+)-K(+) ATPase via S1PR2 and PGE2. |
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Biochem. Cell Biol. |
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Insights into the molecular roles of heparan sulfate proteoglycans (HSPGs-syndecans) in autocrine and paracrine growth factor signaling in the pathogenesis of Hodgkin's lymphoma. |
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Tumour Biol. |
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Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts. |
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Bone |
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Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis. |
2016 |
Trends Endocrinol. Metab. |
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Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate. |
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Pharmacol. Res. |
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Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis. |
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Eur. J. Immunol. |
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Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats. |
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FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. |
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Mol. Cancer Ther. |
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Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells. |
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Cell Biol. Int. |
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Differential elastic responses to barrier-altering agonists in two types of human lung endothelium. |
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Biochem. Biophys. Res. Commun. |
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SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells. |
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Autophagy |
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The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases. |
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J. Lipid Res. |
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Effect of Sphingosine 1-Phosphate on Cyclo-Oxygenase-2 Expression, Prostaglandin E2 Secretion, and β2-Adrenergic Receptor Desensitization. |
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Am. J. Respir. Cell Mol. Biol. |
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Familial hypercholesterolaemia: cholesterol efflux and coronary disease. |
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Eur. J. Clin. Invest. |
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Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. |
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Diabetes |
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Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. |
2016 |
PLoS ONE |
pmid:27187066
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Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. |
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Cell Chem Biol |
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Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling System. |
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COPD |
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The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined. |
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World J Surg Oncol |
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Sphingosine-1-Phosphate Signaling in Endothelial Disorders. |
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Curr Atheroscler Rep |
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Tetracyclines increase lipid phosphate phosphatase expression on plasma membranes and turnover of plasma lysophosphatidate. |
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J. Lipid Res. |
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ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme. |
2016 |
Oncotarget |
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Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence. |
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PLoS ONE |
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Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. |
2016 |
Mediators Inflamm. |
pmid:26884643
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Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion. |
2016 |
Sci Rep |
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Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance. |
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Immunity |
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Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells. |
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Am. J. Physiol., Cell Physiol. |
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Ceramide Signaling and Metabolism in Pathophysiological States of the Lung. |
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Annu. Rev. Physiol. |
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Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors. |
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Curr. Med. Chem. |
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A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC). |
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Mol. Biol. Cell |
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Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner. |
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J. Lipid Res. |
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Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. |
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Biochim. Biophys. Acta |
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Sphk1 promotes breast epithelial cell proliferation via NF-κB-p65-mediated cyclin D1 expression. |
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Oncotarget |
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Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line. |
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J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
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Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. |
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Mol. Hum. Reprod. |
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An oncogenic role for sphingosine kinase 2. |
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Oncotarget |
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Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop. |
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Oncotarget |
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Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation. |
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Pharmacol. Res. |
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Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia. |
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Brain Behav. Immun. |
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Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases. |
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Drug Discov. Today |
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Rosacea: The Blessing of the Celts - An Approach to Pathogenesis Through Translational Research. |
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Acta Derm. Venereol. |
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