Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cummings RJ et al. | Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells. | 2002 | J. Biol. Chem. | pmid:12039947 |
| Cuvillier O | Sphingosine in apoptosis signaling. | 2002 | Biochim. Biophys. Acta | pmid:12531549 |
| Osada M et al. | Modulation of sphingosine 1-phosphate/EDG signaling by tumor necrosis factor-alpha in vascular endothelial cells. | 2002 | Thromb. Res. | pmid:12590954 |
| Renault AD et al. | Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. | 2002 | Gene Expr. Patterns | pmid:12617823 |
| Candelore MR et al. | Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12270137 |
| Harvey K et al. | Serum factors involved in human microvascular endothelial cell morphogenesis. | 2002 | J. Lab. Clin. Med. | pmid:12271276 |
| Katsuma S et al. | Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. | 2002 | Genes Cells | pmid:12485162 |
| Yun JK and Kester M | Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. | 2002 | Arch. Biochem. Biophys. | pmid:12485605 |
| Hirafuji M et al. | [Modulation of sphingosine 1-phosphate, a new lipid mediator, on nitric oxide production by vascular smooth muscle cells]. | 2002 | Nippon Yakurigaku Zasshi | pmid:12491784 |
| Muraki K et al. | [Effects of sphingosine-1-phosphate, a lipid mediator, in cardiovascular tissues]. | 2002 | Nippon Yakurigaku Zasshi | pmid:12491795 |
| Graeler M and Goetzl EJ | Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. | 2002 | FASEB J. | pmid:12468451 |
| Gennero I et al. | Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density. | 2002 | J. Biol. Chem. | pmid:11821388 |
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| Davaille J et al. | Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts. | 2002 | J. Biol. Chem. | pmid:12138095 |
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| Ryu Y et al. | Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells. | 2002 | Circ. Res. | pmid:11861422 |
| Min JK et al. | Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase. | 2002 | Anal. Biochem. | pmid:11950216 |
| Essler M et al. | Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells. | 2002 | Cell. Signal. | pmid:11955953 |
| Endo A et al. | Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII. | 2002 | J. Biol. Chem. | pmid:11956190 |
| Bartholomä P et al. | Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, NF-kappa B and extracellular signal-regulated protein kinase activation. | 2002 | Biochem. Pharmacol. | pmid:11996893 |
| Formigli L et al. | Sphingosine 1-phosphate induces Ca2+ transients and cytoskeletal rearrangement in C2C12 myoblastic cells. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:11997251 |
| Schilling T et al. | Lysophospholipids induce membrane hyperpolarization in microglia by activation of IKCa1 Ca(2+)-dependent K(+) channels. | 2002 | Neuroscience | pmid:11927165 |
| Sano T et al. | Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood. | 2002 | J. Biol. Chem. | pmid:11929870 |
| Spiegel S and Milstien S | Sphingosine 1-phosphate, a key cell signaling molecule. | 2002 | J. Biol. Chem. | pmid:12011102 |
| Kihara A and Igarashi Y | [Sphingosine 1-phosphate in yeast]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915338 |
| Okazaki T and Ito M | [Signal transduction of ceramide]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915339 |
| Jin ZQ et al. | Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12003800 |
| Igarashi Y | [Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915345 |
| Black JL and Johnson PR | Factors controlling smooth muscle proliferation and airway remodelling. | 2002 | Curr Opin Allergy Clin Immunol | pmid:11964750 |
| Brinkmann V et al. | The immune modulator FTY720 targets sphingosine 1-phosphate receptors. | 2002 | J. Biol. Chem. | pmid:11967257 |
| Liu H et al. | Sphingosine kinases: a novel family of lipid kinases. | 2002 | Prog. Nucleic Acid Res. Mol. Biol. | pmid:12102559 |
| Morales M | [Participation of the phosphatidylinositol-3-kinase/Akt/endothelial-nitric-oxide synthase signaling in the processes of angiogenesis and vascular remodeling]. | 2002 | Nefrologia | pmid:12107910 |
| Karliner JS | Lysophospholipids and the cardiovascular system. | 2002 | Biochim. Biophys. Acta | pmid:12069831 |
| English D et al. | Lipid mediators of angiogenesis and the signalling pathways they initiate. | 2002 | Biochim. Biophys. Acta | pmid:12069833 |
| Spiegel S et al. | Sphingosine 1-phosphate signaling: providing cells with a sense of direction. | 2002 | Trends Cell Biol. | pmid:12062172 |
| Kohno T et al. | N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. | 2002 | FASEB J. | pmid:12087059 |
| Mallick S et al. | Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells. | 2002 | J. Biosci. | pmid:12089473 |
| Vouret-Craviari V et al. | Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells. | 2002 | J. Cell. Sci. | pmid:12045218 |
| Kozawa O et al. | Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide. | 2002 | Cell. Signal. | pmid:12359305 |
| Koide Y et al. | Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships. | 2002 | J. Med. Chem. | pmid:12361389 |
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| Jolly PS et al. | The roles of sphingosine-1-phosphate in asthma. | 2002 | Mol. Immunol. | pmid:12217390 |
| Niedernberg A et al. | Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists. | 2002 | Biochem. Pharmacol. | pmid:12234605 |
| Payne SG et al. | Sphingosine-1-phosphate: dual messenger functions. | 2002 | FEBS Lett. | pmid:12401202 |
| Lampasso JD et al. | Role of protein kinase C alpha in primary human osteoblast proliferation. | 2002 | J. Bone Miner. Res. | pmid:12412804 |
| Napier JA et al. | A new class of lipid desaturase central to sphingolipid biosynthesis and signalling. | 2002 | Trends Plant Sci. | pmid:12417141 |
| Uhlenbrock K et al. | Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. | 2002 | Cell. Signal. | pmid:12220620 |