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PLoS ONE |
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Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress. |
2016 |
J R Soc Interface |
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FTY720P inhibits hepatic Na(+)-K(+) ATPase via S1PR2 and PGE2. |
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Insights into the molecular roles of heparan sulfate proteoglycans (HSPGs-syndecans) in autocrine and paracrine growth factor signaling in the pathogenesis of Hodgkin's lymphoma. |
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Tumour Biol. |
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Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts. |
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Trends Endocrinol. Metab. |
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Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis. |
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Differential elastic responses to barrier-altering agonists in two types of human lung endothelium. |
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SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells. |
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Autophagy |
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Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. |
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Diabetes |
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Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. |
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PLoS ONE |
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Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. |
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Cell Chem Biol |
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A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay. |
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Transfus Med |
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Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease. |
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Oncotarget |
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Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence. |
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PLoS ONE |
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Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. |
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Mediators Inflamm. |
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Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion. |
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Sci Rep |
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Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance. |
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Immunity |
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Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway. |
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The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL. |
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Ceramide Signaling and Metabolism in Pathophysiological States of the Lung. |
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A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC). |
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Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. |
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Sphk1 promotes breast epithelial cell proliferation via NF-κB-p65-mediated cyclin D1 expression. |
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Oncotarget |
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Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line. |
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Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. |
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Mol. Hum. Reprod. |
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Oncotarget |
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Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop. |
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Oncotarget |
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Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia. |
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Drug Discov. Today |
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Rosacea: The Blessing of the Celts - An Approach to Pathogenesis Through Translational Research. |
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