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Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes. |
2003 |
Glia |
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2003 |
J. Atheroscler. Thromb. |
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2003 |
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J. Vasc. Res. |
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Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling. |
2004 |
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2004 |
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The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator. |
2004 |
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Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1. |
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2004 |
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Enhancement of sphingosine 1-phosphate-induced phospholipase C activation during G(0)-G(1) transition in rat hepatocytes. |
2004 |
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pmid:15215654
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The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. |
2004 |
Plant Cell |
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Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. |
2004 |
Biochim. Biophys. Acta |
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Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages. |
2004 |
Biochim. Biophys. Acta |
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Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2. |
2004 |
Am. J. Physiol., Cell Physiol. |
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Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells. |
2004 |
J. Neurochem. |
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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. |
2004 |
Nature |
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Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. |
2004 |
Am. J. Respir. Cell Mol. Biol. |
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Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. |
2004 |
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Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. |
2004 |
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pmid:14711826
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The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. |
2004 |
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Platelet-derived sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. |
2004 |
J. Thromb. Haemost. |
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Distinct effects of sphingosine-1-phosphate, lysophosphatidic acid and histamine in human and mouse dendritic cells. |
2004 |
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Sphingosine kinase activation mediates ischemic preconditioning in murine heart. |
2004 |
Circulation |
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High-density lipoprotein stimulates myocardial perfusion in vivo. |
2004 |
Circulation |
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A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. |
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Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition. |
2004 |
J Trauma |
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2004 |
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Differential regulation of ERK1/2 and p38(MAPK) by components of the Rho signaling pathway during sphingosine-1-phosphate-induced smooth muscle cell migration. |
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J. Surg. Res. |
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Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells. |
2004 |
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Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes. |
2004 |
J. Biol. Chem. |
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Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. |
2004 |
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Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors. |
2004 |
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Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. |
2004 |
J. Biol. Chem. |
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Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. |
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Effects of S1P on myoblastic cell contraction: possible involvement of Ca-independent mechanisms. |
2004 |
Cells Tissues Organs (Print) |
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ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism. |
2004 |
Endocr. Res. |
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Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes. |
2004 |
Glia |
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Sphingosine 1-phosphate induces cell contraction via calcium-independent/Rho-dependent pathways in undifferentiated skeletal muscle cells. |
2004 |
J. Cell. Physiol. |
pmid:14584038
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Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis. |
2004 |
J. Biol. Chem. |
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Osteoblastic cells express phospholipid receptors and phosphatases and proliferate in response to sphingosine-1-phosphate. |
2004 |
Calcif. Tissue Int. |
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Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. |
2004 |
Bioorg. Med. Chem. Lett. |
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Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. |
2004 |
J. Biol. Chem. |
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Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism. |
2004 |
Am. J. Physiol., Cell Physiol. |
pmid:15294853
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Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. |
2004 |
Biol. Reprod. |
pmid:15317688
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Hemmings DG et al. |
Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats. |
2004 |
Br. J. Pharmacol. |
pmid:15326035
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Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. |
2004 |
Am. J. Respir. Crit. Care Med. |
pmid:15282202
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Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. |
2004 |
Exp. Cell Res. |
pmid:15265705
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Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis. |
2004 |
J. Immunol. |
pmid:15265887
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Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation. |
2004 |
Biochem. Biophys. Res. Commun. |
pmid:15240112
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Prosaposin: a new player in cell death prevention of U937 monocytic cells. |
2004 |
Exp. Cell Res. |
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