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Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. |
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Neurology |
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The role of sphingolipid signalling in diabetes‑associated pathologies (Review). |
2017 |
Int. J. Mol. Med. |
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Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. |
2017 |
Nature |
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Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking. |
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J. Biol. Chem. |
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Sphingosine-1-Phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche. |
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Stem Cells |
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Selective coupling of the S1P receptor subtype to S1P-mediated RhoA activation and cardioprotection. |
2017 |
J. Mol. Cell. Cardiol. |
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Unsupervised analysis of combined lipid and coagulation data reveals coagulopathy subtypes among dialysis patients. |
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J. Lipid Res. |
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Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients. |
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Arch. Dermatol. Res. |
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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia. |
2017 |
Blood |
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A sphingosine 1-phosphate receptor agonist ameliorates animal model of vasculitis. |
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Inflamm. Res. |
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Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720. |
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Acta Haematol. |
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Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells. |
2017 |
Biofactors |
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Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei. |
2017 |
J. Lipid Res. |
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Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. |
2017 |
Gastroenterology |
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A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma. |
2017 |
Cancer |
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Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer. |
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J. Surg. Res. |
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Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism. |
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Med Res Rev |
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Olesch C et al. |
Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation. |
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Mediators Inflamm. |
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Egom EE et al. |
Determination of Sphingosine-1-Phosphate in Human Plasma Using Liquid Chromatography Coupled with Q-Tof Mass Spectrometry. |
2017 |
Int J Mol Sci |
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An engineered S1P chaperone attenuates hypertension and ischemic injury. |
2017 |
Sci Signal |
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S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1 or Lipocalin-2. |
2017 |
Mediators Inflamm. |
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Acid ceramidase confers radioresistance to glioblastoma cells. |
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Oncol. Rep. |
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Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies. |
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J. Recept. Signal Transduct. Res. |
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Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. |
2017 |
J. Mol. Cell. Cardiol. |
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Pleiotropic effects of sphingosine-1-phosphate signaling to control human chorionic mesenchymal stem cell physiology. |
2017 |
Cell Death Dis |
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Bougault C et al. |
Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. |
2017 |
Bone |
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Tsai CH et al. |
Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. |
2017 |
Mol Oncol |
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Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. |
2017 |
Front Immunol |
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Targeting sphingosine-1-phosphate signaling for cancer therapy. |
2017 |
Sci China Life Sci |
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Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. |
2017 |
Proc. Natl. Acad. Sci. U.S.A. |
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Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression. |
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J. Atheroscler. Thromb. |
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Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. |
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Neuropharmacology |
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Leo A et al. |
The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. |
2017 |
CNS Neurol Disord Drug Targets |
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Roch L et al. |
High-Resolution Expression Profiling of Peripheral Blood CD8 Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. |
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Mol. Neurobiol. |
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Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. |
2017 |
Nature |
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Reinhard NR et al. |
The balance between Gα-Cdc42/Rac and Gα/-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. |
2017 |
Mol. Biol. Cell |
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Natarajan V et al. |
Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. |
2017 |
BMC Genomics |
pmid:28851267
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Hajny S and Christoffersen C |
A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation. |
2017 |
Int J Mol Sci |
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Bertlich M et al. |
Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow. |
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Otol. Neurotol. |
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Koch A et al. |
Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. |
2017 |
Int J Mol Sci |
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Alqinyah M et al. |
Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. |
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Mol. Pharmacol. |
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Endothelial glycocalyx as a critical signalling platform integrating the extracellular haemodynamic forces and chemical signalling. |
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J. Cell. Mol. Med. |
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Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis. |
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Nephrol. Dial. Transplant. |
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Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications. |
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Hum. Mutat. |
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Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. |
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Adv Biol Regul |
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Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania. |
2017 |
Clin. Chim. Acta |
pmid:28159438
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Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? |
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Shock |
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Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. |
2017 |
Front Biosci (Landmark Ed) |
pmid:27814635
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The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. |
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Clin. Cancer Res. |
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High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. |
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Atherosclerosis |
pmid:28038379
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Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation. |
2017 |
Exp. Dermatol. |
pmid:27574180
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HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. |
2017 |
J. Mol. Med. |
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Epithelial cell extrusion: Pathways and pathologies. |
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Semin. Cell Dev. Biol. |
pmid:27212253
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Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices. |
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PLoS ONE |
pmid:29136008
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Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. |
2017 |
PLoS ONE |
pmid:29112690
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Mensah SA et al. |
Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication. |
2017 |
PLoS ONE |
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Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. |
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Exp. Mol. Pathol. |
pmid:28986246
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Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. |
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J. Endocrinol. |
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Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway. |
2017 |
Cell. Physiol. Biochem. |
pmid:28934733
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Kuchler L et al. |
Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. |
2017 |
Mol. Immunol. |
pmid:28846923
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Nicholas SE et al. |
Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. |
2017 |
PLoS ONE |
pmid:28806736
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Lee SY et al. |
Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. |
2017 |
Diabetes |
pmid:28698261
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Hutami IR et al. |
Fas/S1P crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis. |
2017 |
Biochem. Biophys. Res. Commun. |
pmid:28687489
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Cannavo A et al. |
β-Blockade Prevents Post-Ischemic Myocardial Decompensation Via βAR-Dependent Protective Sphingosine-1 Phosphate Signaling. |
2017 |
J. Am. Coll. Cardiol. |
pmid:28683966
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Punsawad C and Viriyavejakul P |
Reduction in serum sphingosine 1-phosphate concentration in malaria. |
2017 |
PLoS ONE |
pmid:28666023
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Luo J et al. |
The effects of berberine on a murine model of multiple sclerosis and the SPHK1/S1P signaling pathway. |
2017 |
Biochem. Biophys. Res. Commun. |
pmid:28655617
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Chang CH and Randolph GJ |
Sphingosine-1-Phosphate as the Lymphocyte's Ticket to Ride and Survive. |
2017 |
Dev. Cell |
pmid:28633013
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Fang R et al. |
Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3β Phosphorylation. |
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Arch. Med. Res. |
pmid:28625317
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Rohrbach T et al. |
Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology. |
2017 |
Crit. Rev. Biochem. Mol. Biol. |
pmid:28618839
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Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. |
2017 |
J. Immunol. |
pmid:28600291
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King A et al. |
Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. |
2017 |
Gastroenterology |
pmid:28363640
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Wollny T et al. |
Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease. |
2017 |
Int J Mol Sci |
pmid:28362332
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Denimal D et al. |
Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Without Diabetes Mellitus to Activate eNOS: Correction by S1P Enrichment. |
2017 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:28360087
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Gusman DH and Shoemake C |
Evaluation and Optimization of designed Sphingosine-1-Phosphate (S1P) Receptor Subtype 1 Modulators for the Management of Multiple Sclerosis. |
2017 |
Yale J Biol Med |
pmid:28356890
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Andrieu G et al. |
Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. |
2017 |
Sci Signal |
pmid:28351953
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Becker S et al. |
Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. |
2017 |
PLoS ONE |
pmid:28334008
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Karunakaran I and van Echten-Deckert G |
Sphingosine 1-phosphate - A double edged sword in the brain. |
2017 |
Biochim. Biophys. Acta |
pmid:28315304
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Navarrete A et al. |
A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. |
2017 |
J Pharm Biomed Anal |
pmid:28314215
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Shirakawa H et al. |
Sphingosine-1-phosphate induces Ca signaling and CXCL1 release via TRPC6 channel in astrocytes. |
2017 |
Glia |
pmid:28300348
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Dyckman AJ |
Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P) Agonists and Future Perspectives. |
2017 |
J. Med. Chem. |
pmid:28291340
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Nielsen OH et al. |
Sphingosine-1-Phosphate Signaling in Inflammatory Bowel Disease. |
2017 |
Trends Mol Med |
pmid:28283249
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Peyrin-Biroulet L et al. |
Modulation of sphingosine-1-phosphate in inflammatory bowel disease. |
2017 |
Autoimmun Rev |
pmid:28279838
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Miller M et al. |
Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate. |
2017 |
J. Immunol. |
pmid:28275141
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Tafelmeier M et al. |
Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:27163393
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FTY720 Attenuates Angiotensin II-Induced Podocyte Damage via Inhibiting Inflammatory Cytokines. |
2017 |
Mediators Inflamm. |
pmid:28270699
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Serafimidis I et al. |
Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. |
2017 |
PLoS Biol. |
pmid:28248965
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Lee HM et al. |
Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. |
2017 |
J. Pathol. |
pmid:28240350
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Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice. |
2017 |
Eur. J. Immunol. |
pmid:28198542
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Bruno M et al. |
Sphingosine 1-phosphate signaling axis mediates fibroblast growth factor 2-induced proliferation and survival of murine auditory neuroblasts. |
2017 |
Biochim. Biophys. Acta |
pmid:28188805
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Tang HB et al. |
S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury. |
2018 |
Biochem. Biophys. Res. Commun. |
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Yu FC et al. |
Protective effect of sphingosine-1-phosphate for chronic intermittent hypoxia-induced endothelial cell injury. |
2018 |
Biochem. Biophys. Res. Commun. |
pmid:29550481
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Nádró B et al. |
[The role of apolipoprotein M and sphingosine 1-phosphate axis in the prevention of atherosclerosis]. |
2018 |
Orv Hetil |
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Deshpande GP et al. |
Sphingosine-1-phosphate (S1P) activates STAT3 to protect against de novo acute heart failure (AHF). |
2018 |
Life Sci. |
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Książek M et al. |
Arteriovenous Sphingosine-1-Phosphate Differences Across Selected Organs of the Rat. |
2018 |
Cell. Physiol. Biochem. |
pmid:29316552
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Huang Y et al. |
S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. |
2018 |
Science |
pmid:29302015
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Ogretmen B |
Sphingolipid metabolism in cancer signalling and therapy. |
2018 |
Nat. Rev. Cancer |
pmid:29147025
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