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Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension. |
2017 |
Cardiovasc. Res. |
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Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. |
2017 |
Neurology |
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The role of sphingolipid signalling in diabetes‑associated pathologies (Review). |
2017 |
Int. J. Mol. Med. |
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Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. |
2017 |
Nature |
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Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking. |
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J. Biol. Chem. |
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Sphingosine-1-Phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche. |
2017 |
Stem Cells |
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Selective coupling of the S1P receptor subtype to S1P-mediated RhoA activation and cardioprotection. |
2017 |
J. Mol. Cell. Cardiol. |
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Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720. |
2017 |
Acta Haematol. |
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González-Fernández B et al. |
Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells. |
2017 |
Biofactors |
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Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei. |
2017 |
J. Lipid Res. |
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Abraham C et al. |
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. |
2017 |
Gastroenterology |
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Katsuta E et al. |
Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer. |
2017 |
J. Surg. Res. |
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Effects of apolipoprotein M in uremic atherosclerosis. |
2017 |
Atherosclerosis |
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Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation. |
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Mediators Inflamm. |
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Determination of Sphingosine-1-Phosphate in Human Plasma Using Liquid Chromatography Coupled with Q-Tof Mass Spectrometry. |
2017 |
Int J Mol Sci |
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An engineered S1P chaperone attenuates hypertension and ischemic injury. |
2017 |
Sci Signal |
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S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1 or Lipocalin-2. |
2017 |
Mediators Inflamm. |
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Acid ceramidase confers radioresistance to glioblastoma cells. |
2017 |
Oncol. Rep. |
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Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies. |
2017 |
J. Recept. Signal Transduct. Res. |
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Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. |
2017 |
J. Mol. Cell. Cardiol. |
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Innamorati G et al. |
Pleiotropic effects of sphingosine-1-phosphate signaling to control human chorionic mesenchymal stem cell physiology. |
2017 |
Cell Death Dis |
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Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. |
2017 |
Bone |
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Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. |
2017 |
Mol Oncol |
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Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. |
2017 |
Front Immunol |
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Alqinyah M et al. |
Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. |
2017 |
Mol. Pharmacol. |
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Garnero P |
The Utility of Biomarkers in Osteoporosis Management. |
2017 |
Mol Diagn Ther |
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Endothelial glycocalyx as a critical signalling platform integrating the extracellular haemodynamic forces and chemical signalling. |
2017 |
J. Cell. Mol. Med. |
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Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis. |
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Nephrol. Dial. Transplant. |
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Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications. |
2017 |
Hum. Mutat. |
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Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania. |
2017 |
Clin. Chim. Acta |
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Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? |
2017 |
Shock |
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Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. |
2017 |
Front Biosci (Landmark Ed) |
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The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. |
2017 |
Clin. Cancer Res. |
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High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. |
2017 |
Atherosclerosis |
pmid:28038379
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Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices. |
2017 |
PLoS ONE |
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Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. |
2017 |
PLoS ONE |
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Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication. |
2017 |
PLoS ONE |
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Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. |
2017 |
Exp. Mol. Pathol. |
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Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. |
2017 |
J. Endocrinol. |
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Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway. |
2017 |
Cell. Physiol. Biochem. |
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Kuchler L et al. |
Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. |
2017 |
Mol. Immunol. |
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Nicholas SE et al. |
Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. |
2017 |
PLoS ONE |
pmid:28806736
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Lee SY et al. |
Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. |
2017 |
Diabetes |
pmid:28698261
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Turner VM and Mabbott NA |
Ageing adversely affects the migration and function of marginal zone B cells. |
2017 |
Immunology |
pmid:28369800
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Müller J et al. |
Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration. |
2017 |
Biomed Res Int |
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Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. |
2017 |
Gastroenterology |
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Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease. |
2017 |
Int J Mol Sci |
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Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Without Diabetes Mellitus to Activate eNOS: Correction by S1P Enrichment. |
2017 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:28360087
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Gusman DH and Shoemake C |
Evaluation and Optimization of designed Sphingosine-1-Phosphate (S1P) Receptor Subtype 1 Modulators for the Management of Multiple Sclerosis. |
2017 |
Yale J Biol Med |
pmid:28356890
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Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. |
2017 |
Sci Signal |
pmid:28351953
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Becker S et al. |
Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. |
2017 |
PLoS ONE |
pmid:28334008
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Karunakaran I and van Echten-Deckert G |
Sphingosine 1-phosphate - A double edged sword in the brain. |
2017 |
Biochim. Biophys. Acta |
pmid:28315304
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A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. |
2017 |
J Pharm Biomed Anal |
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Sphingosine-1-phosphate induces Ca signaling and CXCL1 release via TRPC6 channel in astrocytes. |
2017 |
Glia |
pmid:28300348
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Dyckman AJ |
Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P) Agonists and Future Perspectives. |
2017 |
J. Med. Chem. |
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Involvement of Sphingosine 1-Phosphate in Palmitate-Induced Non-Alcoholic Fatty Liver Disease. |
2016 |
Cell. Physiol. Biochem. |
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Bigaud M et al. |
Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism. |
2016 |
PLoS ONE |
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Surya VN et al. |
Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress. |
2016 |
J R Soc Interface |
pmid:27974574
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Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans. |
2016 |
PLoS ONE |
pmid:27973607
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Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate. |
2016 |
Pharmacol. Res. |
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Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis. |
2016 |
Eur. J. Immunol. |
pmid:27683081
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To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling. |
2016 |
Pharmacol. Res. |
pmid:27663260
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Viswanathan P et al. |
Differential elastic responses to barrier-altering agonists in two types of human lung endothelium. |
2016 |
Biochem. Biophys. Res. Commun. |
pmid:27473658
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Moruno Manchon JF et al. |
SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells. |
2016 |
Autophagy |
pmid:27467777
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Nagahashi M et al. |
The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases. |
2016 |
J. Lipid Res. |
pmid:27459945
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Poissonnier A et al. |
CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice. |
2016 |
Immunity |
pmid:27438772
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Zhang Q et al. |
Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text]. |
2016 |
Am. J. Chin. Med. |
pmid:27430910
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Adamiak M et al. |
Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment After Transplantation. |
2016 |
Cell Transplant |
pmid:27412411
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A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay. |
2016 |
J. Lipid Res. |
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Barnawi J et al. |
Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling System. |
2016 |
COPD |
pmid:27144721
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Jin L et al. |
The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined. |
2016 |
World J Surg Oncol |
pmid:27129720
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Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction. |
2016 |
Transfus Med |
pmid:27350440
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Sphingosine-1-Phosphate Signaling in Endothelial Disorders. |
2016 |
Curr Atheroscler Rep |
pmid:27115142
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Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin. |
2016 |
J. Pineal Res. |
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Sphingosine-1-Phosphate (S1P) Impacts Presynaptic Functions by Regulating Synapsin I Localization in the Presynaptic Compartment. |
2016 |
J. Neurosci. |
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FOXF1 maintains endothelial barrier function and prevents edema after lung injury. |
2016 |
Sci Signal |
pmid:27095594
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Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. |
2016 |
Cell. Signal. |
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Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease. |
2016 |
Sci Rep |
pmid:27830727
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Tetracyclines increase lipid phosphate phosphatase expression on plasma membranes and turnover of plasma lysophosphatidate. |
2016 |
J. Lipid Res. |
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Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion. |
2016 |
Sci Rep |
pmid:26877098
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Luo B et al. |
Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance. |
2016 |
Immunity |
pmid:26872696
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Li J et al. |
Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway. |
2016 |
Tumour Biol. |
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The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL. |
2016 |
Free Radic. Biol. Med. |
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The Role of Sphingosine-1-Phosphate in Adipogenesis of Graves' Orbitopathy. |
2016 |
Invest. Ophthalmol. Vis. Sci. |
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A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC). |
2016 |
Mol. Biol. Cell |
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Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner. |
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J. Lipid Res. |
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Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. |
2016 |
Biochim. Biophys. Acta |
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Sphingosine-1-phosphate and estrogen signaling in breast cancer. |
2016 |
Adv Biol Regul |
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Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction. |
2016 |
Am. J. Physiol. Heart Circ. Physiol. |
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A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. |
2016 |
Prog. Lipid Res. |
pmid:26584871
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Gao D et al. |
Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line. |
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J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
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An oncogenic role for sphingosine kinase 2. |
2016 |
Oncotarget |
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Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop. |
2016 |
Oncotarget |
pmid:27556509
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Nagahashi M et al. |
Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods. |
2016 |
J Mammary Gland Biol Neoplasia |
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Patmanathan SN et al. |
Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. |
2016 |
Sci Rep |
pmid:27160553
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Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation. |
2016 |
Pharmacol. Res. |
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Implication of sphingosin-1-phosphate in cardiovascular regulation. |
2016 |
Front Biosci (Landmark Ed) |
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Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia. |
2016 |
Brain Behav. Immun. |
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Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases. |
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Drug Discov. Today |
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Resveratrol exerts a biphasic effect on apolipoprotein M. |
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Br. J. Pharmacol. |
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