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Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro. |
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Cell. Signal. |
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Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis. |
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Respirology |
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Eur. J. Clin. Invest. |
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Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases. |
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Neuropharmacology |
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Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. |
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PLoS ONE |
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Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. |
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A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma. |
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Cancer |
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Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism. |
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Med Res Rev |
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Cell Death Dis |
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Mol Oncol |
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J. Atheroscler. Thromb. |
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Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. |
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Neuropharmacology |
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The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. |
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High-Resolution Expression Profiling of Peripheral Blood CD8 Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. |
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Mol. Neurobiol. |
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Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. |
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Nature |
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Mol. Biol. Cell |
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Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. |
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BMC Genomics |
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A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation. |
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Int J Mol Sci |
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Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow. |
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Int J Mol Sci |
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PLoS ONE |
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The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis. |
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PLoS ONE |
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Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. |
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Front Biosci (Landmark Ed) |
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The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. |
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Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. |
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Nature |
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A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. |
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Dev. Cell |
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Expert Opin. Ther. Targets |
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Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy. |
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Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma. |
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A Shift in ApoM/S1P Between HDL-Particles in Women With Type 1 Diabetes Mellitus Is Associated With Impaired Anti-Inflammatory Effects of the ApoM/S1P Complex. |
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Immunology |
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Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration. |
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Biomed Res Int |
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HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium. |
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Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. |
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Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. |
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Diabetes |
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Am. J. Physiol., Cell Physiol. |
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The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice. |
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Aging Cell |
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Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes. |
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Cancer Invest. |
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Involvement of CETP (Cholesteryl Ester Transfer Protein) in the Shift of Sphingosine-1-Phosphate Among Lipoproteins and in the Modulation of its Functions. |
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Arterioscler. Thromb. Vasc. Biol. |
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The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. |
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Hepatology |
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Hypothalamic S1P/S1PR1 axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise. |
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Leukemia |
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Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function. |
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Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. |
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The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells. |
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Stem Cell Rev |
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Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells. |
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Cell Calcium |
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Cell. Signal. |
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Sphingosine 1‑phosphate induced by hypoxia increases the expression of PAI‑1 in HepG2 cells via HIF‑1α. |
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Mol Med Rep |
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Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection. |
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Pathog Dis |
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Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis. |
2016 |
Sci Signal |
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Tumor microenvironment on the move and the Aselli connection. |
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Sci Signal |
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Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane. |
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Am. J. Physiol. Gastrointest. Liver Physiol. |
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Sphingosine-1-phosphate receptor 1 as a prognostic biomarker and therapeutic target for patients with primary testicular diffuse large B-cell lymphoma. |
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Br. J. Haematol. |
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Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human TÂ cells from the thymus to the periphery. |
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J. Allergy Clin. Immunol. |
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Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1). |
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Bioorg. Med. Chem. Lett. |
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Sphingosine Kinases: Emerging Structure-Function Insights. |
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Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion. |
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Inflamm. Res. |
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Potential serum biomarkers from a metabolomics study of autism. |
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J Psychiatry Neurosci |
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Sphingosine 1-phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons. |
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Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status. |
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Oxid Med Cell Longev |
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Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors. |
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Sci Rep |
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Sphingosine 1-phosphate signaling in astrocytes: Implications for progressive multiple sclerosis. |
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J. Neurol. Sci. |
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Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. |
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Am. J. Hum. Genet. |
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Sphingosine 1-phospate differentially modulates maturation and function of human Langerhans-like cells. |
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The influence of metal-based biomaterials functionalized with sphingosine-1-phosphate on the cellular response and osteogenic differentaion potenial of human adipose derived mesenchymal stem cells in vitro. |
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J Biomater Appl |
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Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720. |
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Mechanism of sphingosine-1-phosphate induced cardioprotection against I/R injury in diabetic rat heart: Possible involvement of glycogen synthase kinase 3β and mitochondrial permeability transition pore. |
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Clin. Exp. Pharmacol. Physiol. |
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C1q/TNF-related protein-1 functions to protect against acute ischemic injury in the heart. |
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Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells. |
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Stem Cell Rev |
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Sphingosine-1-phosphate Maintains Normal Vascular Permeability by Preserving Endothelial Surface Glycocalyx in Intact Microvessels. |
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Microcirculation |
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Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy. |
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Clin. Exp. Pharmacol. Physiol. |
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The circulating sphingosine-1-phosphate level predicts incident fracture in postmenopausal women: a 3.5-year follow-up observation study. |
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FTY720 (Fingolimod) attenuates basal and sphingosine-1-phosphate-evoked thyroid cancer cell invasion. |
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Endocr. Relat. Cancer |
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IL-15 boosts the function and migration of human terminally differentiated CD8+ T cells by inducing a unique gene signature. |
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Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. |
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J. Hepatol. |
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The effect of sphingosine-1-phosphate on bone metabolism in humans depends on its plasma/bone marrow gradient. |
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Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function. |
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Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes. |
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