| MeSH term | MeSH ID | Detail |
|---|---|---|
| Sarcoma 180 | D012510 | 21 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Afrasiabi E et al. | Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. | 2006 | Cell. Signal. | pmid:16490345 |
| Huwiler A and Pfeilschifter J | Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy. | 2006 | Curr. Pharm. Des. | pmid:17168766 |
| Dindo D et al. | Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. | 2006 | Mol. Cancer Ther. | pmid:16818511 |
| Durand CA et al. | The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. | 2006 | Eur. J. Immunol. | pmid:16821235 |
| Giussani P et al. | Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. | 2006 | Mol. Cell. Biol. | pmid:16782891 |
| Barthomeuf C et al. | Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. | 2006 | Free Radic. Biol. Med. | pmid:16458188 |
| di Villa Bianca Rd et al. | Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16234413 |
| Bu S et al. | Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. | 2006 | FASEB J. | pmid:16278291 |
| Matsuyuki H et al. | Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P. | 2006 | Cell. Mol. Immunol. | pmid:17257496 |
| Tardieu D et al. | Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. | 2006 | Chem. Biol. Interact. | pmid:16412405 |
| Naetzker S et al. | Activation of p38 mitogen-activated protein kinase and partial reactivation of the cell cycle by cis-4-methylsphingosine direct postmitotic neurons towards apoptosis. | 2006 | Genes Cells | pmid:16483315 |
| Jurisicova A et al. | Molecular requirements for doxorubicin-mediated death in murine oocytes. | 2006 | Cell Death Differ. | pmid:16439991 |
| Bassi R et al. | Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors. | 2006 | Glia | pmid:16470810 |
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| Phan VH et al. | Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila. | 2007 | Dev. Biol. | pmid:17706961 |
| Mechtcheriakova D et al. | Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. | 2007 | Cell. Signal. | pmid:17113265 |
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| Ki SH et al. | Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha. | 2007 | J. Biol. Chem. | pmid:17098744 |
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| Formigli L et al. | Cytoskeleton/stretch-activated ion channel interaction regulates myogenic differentiation of skeletal myoblasts. | 2007 | J. Cell. Physiol. | pmid:17295211 |
| Smicun Y et al. | S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells. | 2007 | Gynecol. Oncol. | pmid:17716713 |
| Chilton L et al. | Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts. | 2007 | J. Physiol. (Lond.) | pmid:17569734 |
| Currie JC et al. | MT1-MMP down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells: a molecular link between pro-MMP-2 activation, chemotaxis, and cell survival. | 2007 | J. Biol. Chem. | pmid:17229722 |
| Beech DJ | Bipolar phospholipid sensing by TRPC5 calcium channel. | 2007 | Biochem. Soc. Trans. | pmid:17233612 |
| Kunisawa J et al. | Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. | 2007 | Blood | pmid:17234743 |
| Martino A et al. | Sphingosine 1-phosphate interferes on the differentiation of human monocytes into competent dendritic cells. | 2007 | Scand. J. Immunol. | pmid:17212771 |
| Johnstone ED et al. | Epidermal growth factor and sphingosine-1-phosphate stimulate Na+/H+ exchanger activity in the human placental syncytiotrophoblast. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17913870 |
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| Baran Y et al. | Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. | 2007 | J. Biol. Chem. | pmid:17303574 |
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| Santucci MB et al. | Sphingosine 1-phosphate promotes antigen processing and presentation to CD4+ T cells in Mycobacterium tuberculosis-infected monocytes. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17673170 |
| Tao R et al. | Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes. | 2007 | Cardiovasc. Res. | pmid:17320845 |
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| Osada M et al. | Involvement of sphingosine 1-phosphate, a platelet-derived bioactive lipid, in contraction of mesangium cells. | 2007 | J. Biochem. | pmid:17646176 |
| Weigert A et al. | Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate. | 2007 | Mol. Biol. Cell | pmid:17652460 |
| Lin CI et al. | Sphingosine 1-phosphate regulates inflammation-related genes in human endothelial cells through S1P1 and S1P3. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17331465 |
| Mulders AC et al. | Effects of sphingosine-1-phosphate and sphingosylphosphorylcholine on intracellular Ca2+ and cell death in prostate cancer cell lines. | 2007 | Auton Autacoid Pharmacol | pmid:18076478 |
| Kimura A et al. | Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. | 2007 | Stem Cells | pmid:16990586 |
| Schwab SR and Cyster JG | Finding a way out: lymphocyte egress from lymphoid organs. | 2007 | Nat. Immunol. | pmid:18026082 |
| Leiber D et al. | Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:16956968 |
| Koh E et al. | Sphingosine-1-phosphate initiates rapid retraction of pseudopodia by localized RhoA activation. | 2007 | Cell. Signal. | pmid:17307336 |
| Torkhovskaya TI et al. | Lysophospholipid receptors in cell signaling. | 2007 | Biochemistry Mosc. | pmid:17367289 |
| Furukawa A et al. | Production of nerve growth factor enhanced in cultured mouse astrocytes by glycerophospholipids, sphingolipids, and their related compounds. | 2007 | Mol. Cell. Biochem. | pmid:17577630 |
| Soares R and Azevedo I | Inhibition of S1P by polyphenols prevents inflammation and angiogenesis: NFkappaB, a downstream effector? | 2007 | Free Radic. Biol. Med. | pmid:17189836 |
| Hancke K et al. | Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo. | 2007 | Fertil. Steril. | pmid:17081530 |