| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypersensitivity | D006967 | 22 associated lipids |
| Pulmonary Edema | D011654 | 23 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Muraki K | [Analyses of Ca-related ion channel currents and their involvement in Ca mobilization in smooth muscle and endothelial cells]. | 2003 | Nippon Yakurigaku Zasshi | pmid:12673948 |
| Spiegel S and Milstien S | Sphingosine-1-phosphate: an enigmatic signalling lipid. | 2003 | Nat. Rev. Mol. Cell Biol. | pmid:12728273 |
| Takeya H et al. | Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells. | 2003 | Blood | pmid:12730100 |
| Mendel J et al. | Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans. | 2003 | J. Biol. Chem. | pmid:12682045 |
| Ignatov A et al. | Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. | 2003 | J. Neurosci. | pmid:12574419 |
| Ikeda H et al. | Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. | 2003 | Gastroenterology | pmid:12557151 |
| Rábano M et al. | Sphingosine-1-phosphate stimulates cortisol secretion. | 2003 | FEBS Lett. | pmid:12560086 |
| Florio T et al. | Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis. | 2003 | Mol. Pharmacol. | pmid:12527801 |
| Cho H et al. | The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling. | 2003 | Biochem. J. | pmid:12564955 |
| Jin Y et al. | Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. | 2003 | Blood | pmid:12586615 |
| Meyer zu Heringdorf D et al. | Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors. | 2003 | FEBS Lett. | pmid:14623109 |
| Kohno T and Igarashi Y | Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1/S1P1 receptor. | 2003 | J. Biochem. | pmid:14688232 |
| Dolezalova H et al. | Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. | 2003 | J. Cell. Biochem. | pmid:12577307 |
| Suomalainen L et al. | Sphingosine-1-phosphate in inhibition of male germ cell apoptosis in the human testis. | 2003 | J. Clin. Endocrinol. Metab. | pmid:14602806 |
| Einicker-Lamas M et al. | Sphingosine-1-phosphate formation activates phosphatidylinositol-4 kinase in basolateral membranes from kidney cells: crosstalk in cell signaling through sphingolipids and phospholipids. | 2003 | J. Biochem. | pmid:14607979 |
| Cho H et al. | Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. | 2003 | FASEB J. | pmid:12514120 |
| Castillo SS and Teegarden D | Sphingosine-1-phosphate inhibition of apoptosis requires mitogen-activated protein kinase phosphatase-1 in mouse fibroblast C3H10T 1/2 cells. | 2003 | J. Nutr. | pmid:14608042 |
| Waters C et al. | Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells. | 2003 | J. Biol. Chem. | pmid:12480944 |
| Lim HS et al. | Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12482430 |
| Shikata Y et al. | S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin. | 2003 | J. Appl. Physiol. | pmid:12482769 |
| Meacci E et al. | Activation of phospholipase D by bradykinin and sphingosine 1-phosphate in A549 human lung adenocarcinoma cells via different GTP-binding proteins and protein kinase C delta signaling pathways. | 2003 | Biochemistry | pmid:12525155 |
| Katsuma S et al. | Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12504122 |
| Kim DS et al. | Sphingosine-1-phosphate promotes mouse melanocyte survival via ERK and Akt activation. | 2003 | Cell. Signal. | pmid:12873705 |
| Kohno T et al. | Sphingosine 1-phosphate promotes cell migration through the activation of Cdc42 in Edg-6/S1P4-expressing cells. | 2003 | Genes Cells | pmid:12875654 |
| Kihara A et al. | Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. | 2003 | J. Biol. Chem. | pmid:12584204 |
| Berg C et al. | Platelets induce reactive oxygen species-dependent growth of human skin fibroblasts. | 2003 | Eur. J. Cell Biol. | pmid:14703013 |
| Wang J et al. | [Sphingolipid and apoptosis]. | 2003 | Sheng Li Ke Xue Jin Zhan | pmid:14628466 |
| Esch SW et al. | Sphingolipid profile in the CNS of the twitcher (globoid cell leukodystrophy) mouse: a lipidomics approach. | 2003 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:14528915 |
| Brailoiu E et al. | Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). | 2003 | Biochem. J. | pmid:12749764 |
| Hla T | Signaling and biological actions of sphingosine 1-phosphate. | 2003 | Pharmacol. Res. | pmid:12676514 |
| Buccoliero R and Futerman AH | The roles of ceramide and complex sphingolipids in neuronal cell function. | 2003 | Pharmacol. Res. | pmid:12676515 |
| Bernatchez PN et al. | Sphingosine 1-phosphate effect on endothelial cell PAF synthesis: role in cellular migration. | 2003 | J. Cell. Biochem. | pmid:14587028 |
| Meacci E et al. | Down-regulation of EDG5/S1P2 during myogenic differentiation results in the specific uncoupling of sphingosine 1-phosphate signalling to phospholipase D. | 2003 | Biochim. Biophys. Acta | pmid:14499732 |
| Ozaki H et al. | Sphingosine-1-phosphate signaling in endothelial activation. | 2003 | J. Atheroscler. Thromb. | pmid:14564080 |
| Bayless KJ and Davis GE | Sphingosine-1-phosphate markedly induces matrix metalloproteinase and integrin-dependent human endothelial cell invasion and lumen formation in three-dimensional collagen and fibrin matrices. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14651957 |
| Morii T and Weissbach L | Sphingosine 1-phosphate and cell migration: resistance to angiogenesis inhibitors. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14550287 |
| Meacci E et al. | Sphingosine 1-phosphate signal transduction in muscle cells. | 2003 | Ital. J. Biochem. | pmid:12833634 |
| Villullas IR et al. | Characterisation of a sphingosine 1-phosphate-activated Ca2+ signalling pathway in human neuroblastoma cells. | 2003 | J. Neurosci. Res. | pmid:12836164 |
| Schaphorst KL et al. | Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12626332 |
| Malik ZA et al. | Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase. | 2003 | J. Immunol. | pmid:12626530 |
| Mao C et al. | Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. | 2003 | J. Biol. Chem. | pmid:12783875 |
| Chihab R et al. | Sphingosine 1-phosphate antagonizes human neutrophil apoptosis via p38 mitogen-activated protein kinase. | 2003 | Cell. Mol. Life Sci. | pmid:12785724 |
| Coursol S et al. | Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins. | 2003 | Nature | pmid:12789341 |
| Watterson K et al. | Pleiotropic actions of sphingosine-1-phosphate. | 2003 | Prog. Lipid Res. | pmid:12790117 |
| Bolz SS et al. | Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway. | 2003 | Circulation | pmid:12796138 |
| Kim JI et al. | Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells. | 2003 | J. Biol. Chem. | pmid:12796504 |
| Thors B et al. | Inhibition of Akt phosphorylation by thrombin, histamine and lysophosphatidylcholine in endothelial cells. Differential role of protein kinase C. | 2003 | Atherosclerosis | pmid:12801607 |
| Yamaguchi H et al. | Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells. | 2003 | Biochem. J. | pmid:12803545 |
| Miura S et al. | Ras/Raf1-dependent signal in sphingosine-1-phosphate-induced tube formation in human coronary artery endothelial cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12821130 |
| Vogler R et al. | Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. | 2003 | J. Invest. Dermatol. | pmid:12648236 |