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Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. |
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The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. |
2004 |
Plant Cell |
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Biochim. Biophys. Acta |
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2004 |
Biochim. Biophys. Acta |
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2004 |
Am. J. Physiol., Cell Physiol. |
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Ceramide lances the lungs. |
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Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts. |
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Am. J. Physiol., Cell Physiol. |
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Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. |
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Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. |
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The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. |
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2004 |
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Sphingosine kinase activation mediates ischemic preconditioning in murine heart. |
2004 |
Circulation |
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Eur. J. Pharmacol. |
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Atherosclerosis |
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S1P and LPA trigger Schwann cell actin changes and migration. |
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Eur. J. Neurosci. |
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A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. |
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J Trauma |
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Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells. |
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Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation. |
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Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. |
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ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism. |
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Endocr. Res. |
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Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. |
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Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis. |
2004 |
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Osteoblastic cells express phospholipid receptors and phosphatases and proliferate in response to sphingosine-1-phosphate. |
2004 |
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Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. |
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Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. |
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Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism. |
2004 |
Am. J. Physiol., Cell Physiol. |
pmid:15294853
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Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. |
2004 |
Biol. Reprod. |
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Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats. |
2004 |
Br. J. Pharmacol. |
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Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. |
2004 |
Am. J. Respir. Crit. Care Med. |
pmid:15282202
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Biologically active sphingolipids in cancer pathogenesis and treatment. |
2004 |
Nat. Rev. Cancer |
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