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Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. |
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Blood |
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Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis. |
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Diverse effects of sphingosine on calcium mobilization and influx in differentiated HL-60 cells. |
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Cell. Mol. Life Sci. |
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Protecting the female germ line from cancer therapy. |
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Nat. Med. |
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Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. |
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Mol. Pharmacol. |
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Developmental biology. Bringing two hearts together. |
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Nature |
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A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development. |
2000 |
Nature |
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Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Receptor-activated phospholipase D is present in caveolin-3-enriched light membranes of C2C12 myotubes. |
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FEBS Lett. |
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Sphingosine 1-phosphate amplifies phosphoinositide hydrolysis stimulated by prostaglandin f2 alpha in osteoblasts: involvement of p38MAP kinase. |
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Prostaglandins Leukot. Essent. Fatty Acids |
pmid:10913228
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Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. |
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Arch. Biochem. Biophys. |
pmid:10683250
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Selective stimulation by ceramide of the expression of the alpha isoform of retinoic acid and retinoid X receptors in osteoblastic cells. A role of sphingosine 1-phosphate-mediated AP-1 in the ligand-dependent transcriptional activity of these receptors. |
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J. Biol. Chem. |
pmid:10915783
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