Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

Cross Reference

Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Fibrosis D005355 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Pulmonary Edema D011654 23 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Endotoxemia D019446 27 associated lipids
Glioblastoma D005909 27 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Insulinoma D007340 28 associated lipids
Neuralgia D009437 28 associated lipids
Proteinuria D011507 30 associated lipids
Acute Lung Injury D055371 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Acne Vulgaris D000152 35 associated lipids
Anaphylaxis D000707 35 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Authors Title Published Journal PubMed Link
Price MM et al. A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. 2013 J. Allergy Clin. Immunol. pmid:22939756
Kimizuka K et al. Sphingosine 1-phosphate (S1P) induces S1P2 receptor-dependent tonic contraction in murine iliac lymph vessels. 2013 Microcirculation pmid:22913344
Koch A et al. PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. 2013 Biochim. Biophys. Acta pmid:23906789
Herzog BH et al. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. 2013 Nature pmid:23995678
Kotani T et al. Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor. 2013 Biol. Reprod. pmid:23863409
Zhao CG et al. Sphingosine-1-phosphate is a possible fibrogenic factor in gluteal muscle fibrosis. 2013 Physiol Res pmid:23869887
Knapp M et al. Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction. 2013 Prostaglandins Other Lipid Mediat. pmid:24120760
Yuan S et al. Lipid receptor S1P₁ activation scheme concluded from microsecond all-atom molecular dynamics simulations. 2013 PLoS Comput. Biol. pmid:24098103
Gaveglio VL et al. Phosphatidic acid metabolism in rat liver cell nuclei. 2013 FEBS Lett. pmid:23439070
Wirotanseng LN et al. Gq rather than G11 preferentially mediates nociceptor sensitization. 2013 Mol Pain pmid:24156378
Kurek K et al. [The role of sphingolipids in selected cardiovascular diseases]. 2013 Postepy Hig Med Dosw (Online) pmid:24088546
Kowalski GM et al. Plasma sphingosine-1-phosphate is elevated in obesity. 2013 PLoS ONE pmid:24039766
Ohotski J et al. Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer. 2013 Int. J. Cancer pmid:22733311
Chan H and Pitson SM Post-translational regulation of sphingosine kinases. 2013 Biochim. Biophys. Acta pmid:22801036
Orr Gandy KA and Obeid LM Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors. 2013 Biochim. Biophys. Acta pmid:22801037
Herr DR et al. Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. 2013 J. Biol. Chem. pmid:24003216
Dave JM et al. Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). 2013 J. Biol. Chem. pmid:24005669
Deng H et al. Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis. 2013 ACS Med Chem Lett pmid:24900589
Zhang W et al. Sphingosine-1-phosphate receptor-2 mediated NFκB activation contributes to tumor necrosis factor-α induced VCAM-1 and ICAM-1 expression in endothelial cells. 2013 Prostaglandins Other Lipid Mediat. pmid:23770055
Selhub J et al. Dietary vitamin B6 intake modulates colonic inflammation in the IL10-/- model of inflammatory bowel disease. 2013 J. Nutr. Biochem. pmid:24183308
Brewer JW Phospholipids: "greasing the wheels" of humoral immunity. 2013 Biochim. Biophys. Acta pmid:23051607
Ishii M and Kikuta J Sphingosine-1-phosphate signaling controlling osteoclasts and bone homeostasis. 2013 Biochim. Biophys. Acta pmid:22691949
Ley S et al. The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages. 2013 Oncogene pmid:22410777
Dziak R The role of sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) in regulation of osteoclastic and osteoblastic cells. 2013 Immunol. Invest. pmid:24004055
Schwalm S et al. Sphingosine-1-phosphate: a Janus-faced mediator of fibrotic diseases. 2013 Biochim. Biophys. Acta pmid:22889995
Xiong Y et al. Sphingosine kinases are not required for inflammatory responses in macrophages. 2013 J. Biol. Chem. pmid:24081141
Zhang W et al. ETS-1-mediated transcriptional up-regulation of CD44 is required for sphingosine-1-phosphate receptor subtype 3-stimulated chemotaxis. 2013 J. Biol. Chem. pmid:24064218
Babahosseini H et al. Bioactive sphingolipid metabolites modulate ovarian cancer cell structural mechanics. 2013 Integr Biol (Camb) pmid:24056950
Zhang O et al. Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence. 2013 Mol. Microbiol. pmid:23980754
Tran-Dinh A et al. HDL and endothelial protection. 2013 Br. J. Pharmacol. pmid:23488589
Mudd JC et al. Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes. 2013 Blood pmid:23422746
Olivera A et al. Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. 2013 J. Leukoc. Biol. pmid:23904439
Camacho L et al. Acid ceramidase as a therapeutic target in metastatic prostate cancer. 2013 J. Lipid Res. pmid:23423838
Sun X et al. Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. 2013 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:23911438
Hardin C et al. Glassy dynamics, cell mechanics, and endothelial permeability. 2013 J Phys Chem B pmid:23638866
Xiang SY et al. PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. 2013 Sci Signal pmid:24345679
Riccitelli E et al. Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival. 2013 PLoS ONE pmid:23826381
Wang Y et al. Epidermal growth factor receptor signaling-dependent calcium elevation in cumulus cells is required for NPR2 inhibition and meiotic resumption in mouse oocytes. 2013 Endocrinology pmid:23787120
Wang Z et al. Molecular basis of sphingosine kinase 1 substrate recognition and catalysis. 2013 Structure pmid:23602659
Salmanzadeh A et al. Sphingolipid metabolites modulate dielectric characteristics of cells in a mouse ovarian cancer progression model. 2013 Integr Biol (Camb) pmid:23609351
Orr Gandy KA et al. Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. 2013 FASEB J. pmid:23629860
Schneider G et al. Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy. 2013 Mol. Cancer Res. pmid:23615526
Goyal P et al. Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways. 2013 Mol. Hum. Reprod. pmid:23538947
Cinq-Frais C et al. A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. 2013 Biochim. Biophys. Acta pmid:23651497
Christoffersen C and Nielsen LB Apolipoprotein M: bridging HDL and endothelial function. 2013 Curr. Opin. Lipidol. pmid:23652568
Egom EE et al. HDL quality or cholesterol cargo: what really matters--spotlight on sphingosine-1-phosphate-rich HDL. 2013 Curr. Opin. Lipidol. pmid:23652570
Lundblad C et al. Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat. 2013 Acta Anaesthesiol Scand pmid:23683126
Kroetsch JT and Bolz SS The TNF-α/sphingosine-1-phosphate signaling axis drives myogenic responsiveness in heart failure. 2013 J. Vasc. Res. pmid:23594703
Allende ML et al. Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis. 2013 J. Biol. Chem. pmid:23637227
Schaper K et al. Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis. 2013 J. Dermatol. Sci. pmid:23643308
Böhm A et al. Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells. 2013 Cardiovasc. Res. pmid:23658376
Kurano M et al. Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M. 2013 Atherosclerosis pmid:23664237
Stradner MH et al. Sphingosine 1-phosphate counteracts the effects of interleukin-1β in human chondrocytes. 2013 Arthritis Rheum. pmid:23666803
Usatyuk PV et al. Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction. 2013 PLoS ONE pmid:23667561
Matsuzaki E et al. Sphingosine-1-phosphate promotes the nuclear translocation of β-catenin and thereby induces osteoprotegerin gene expression in osteoblast-like cell lines. 2013 Bone pmid:23612487
Sharma N et al. Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells. 2013 J. Leukoc. Biol. pmid:23345392
Salvemini D et al. Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain. 2013 Trends Pharmacol. Sci. pmid:23318139
Tibolla G et al. Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis. 2013 PLoS ONE pmid:23320105
Lee YJ et al. Sphingosine-1-phosphate protects against bisphosphonate‑induced HUVEC cell death via regulation of c-Jun‑N‑terminal kinase signaling. 2013 Int. J. Mol. Med. pmid:23381659
Yangyuoru PM et al. Fluorescent lipids as probes for sphingosine kinase activity by capillary electrophoresis. 2013 Methods Mol. Biol. pmid:23386355
Dillahunt SE et al. Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined. 2013 J. Immunol. pmid:23359503
Tong X et al. High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate. 2013 Cardiovasc Diabetol pmid:23360427
Finley A et al. Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. 2013 PLoS ONE pmid:23372844
Dusaban SS et al. Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23401561
Del Galdo S et al. The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis. 2013 Cell. Signal. pmid:23993968
Gandy KA et al. Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. 2013 Biochem. J. pmid:23106337
Pantoja M et al. Genetic elevation of sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila. 2013 Development pmid:23154413
Kalhori V et al. Sphingosine-1-Phosphate as a Regulator of Hypoxia-Induced Factor-1α in Thyroid Follicular Carcinoma Cells. 2013 PLoS ONE pmid:23824493
Guo H et al. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. 2013 J. Neurosci. pmid:23554499
Carr JM et al. Sphingosine kinase 1 in viral infections. 2013 Rev. Med. Virol. pmid:22639116
Di Menna L et al. Fingolimod protects cultured cortical neurons against excitotoxic death. 2013 Pharmacol. Res. pmid:23073075
Lotinun S et al. Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation. 2013 J. Clin. Invest. pmid:23321671
Zu Heringdorf DM et al. Pharmacology of the sphingosine-1-phosphate signalling system. 2013 Handb Exp Pharmacol pmid:23579459
Matheu MP et al. Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. 2013 PLoS ONE pmid:23533579
Sobel K et al. Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. 2013 J. Biol. Chem. pmid:23589284
Barth BM et al. Gaucher's disease and cancer: a sphingolipid perspective. 2013 Crit Rev Oncog pmid:23510065
Bernhart E et al. Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro. 2013 Exp. Cell Res. pmid:23562655
Selvam SP and Ogretmen B Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance. 2013 Handb Exp Pharmacol pmid:23563649
Pyne S and Pyne NJ New perspectives on the role of sphingosine 1-phosphate in cancer. 2013 Handb Exp Pharmacol pmid:23563651
Jiang XC and Liu J Sphingolipid metabolism and atherosclerosis. 2013 Handb Exp Pharmacol pmid:23563655
Levkau B Cardiovascular effects of sphingosine-1-phosphate (S1P). 2013 Handb Exp Pharmacol pmid:23563656
Abbasi T and Garcia JG Sphingolipids in lung endothelial biology and regulation of vascular integrity. 2013 Handb Exp Pharmacol pmid:23563658
Gandy KA and Obeid LM Regulation of the sphingosine kinase/sphingosine 1-phosphate pathway. 2013 Handb Exp Pharmacol pmid:23563662
Bruni P and Donati C Role of sphingosine 1-phosphate in skeletal muscle cell biology. 2013 Handb Exp Pharmacol pmid:23563671
Park K et al. Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production. 2013 J. Invest. Dermatol. pmid:23856934
Huang LS et al. Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis. 2013 FASEB J. pmid:23315259
Lukowski ZL et al. Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (Sonepcizumab) in a rabbit model. 2013 J. Glaucoma pmid:21946553
Chang CH et al. Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro. 2013 Acta Pharmacol. Sin. pmid:23377549
Cuvillier O et al. Hypoxia, therapeutic resistance, and sphingosine 1-phosphate. 2013 Adv. Cancer Res. pmid:23290779
Alshaker H et al. Therapeutic potential of targeting SK1 in human cancers. 2013 Adv. Cancer Res. pmid:23290780
Heffernan-Stroud LA and Obeid LM Sphingosine kinase 1 in cancer. 2013 Adv. Cancer Res. pmid:23290781
Zhang J et al. Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration. 2013 Hum. Reprod. pmid:24001716
Kihara A [Complete metabolic pathway of sphingosine 1-phosphate and its importance as a metabolic intermediate]. 2013 Seikagaku pmid:23980469
Knapp M et al. Dose-dependent effect of aspirin on the level of sphingolipids in human blood. 2013 Adv Med Sci pmid:24101372
Weichand B et al. Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration. 2013 Eur. J. Immunol. pmid:23934754
Morad SA et al. Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells. 2013 Biochim. Biophys. Acta pmid:23939396
Banitalebi E et al. The effect of resistance training on plasma S1P level and gene expression of S1P1,2,3 receptors in male Wistar rats. 2013 Minerva Endocrinol. pmid:24285107
Rokka J et al. 19F/18F exchange synthesis for a novel [18F]S1P3-radiopharmaceutical. 2013 J Labelled Comp Radiopharm pmid:24285478
Kajimoto T et al. Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes. 2013 Nat Commun pmid:24231649
Ito S et al. Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes. 2013 Coron. Artery Dis. pmid:24212262