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Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function. |
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Eur. J. Pharmacol. |
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Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium. |
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J. Biol. Chem. |
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Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells. |
2016 |
Respir. Res. |
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Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice. |
2016 |
Stroke |
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Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells. |
2016 |
Cell Calcium |
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Sphingosylphosphorylcholine regulates the Hippo signaling pathway in a dual manner. |
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Cell. Signal. |
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Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei. |
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Mol. Microbiol. |
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Targeting sphingosine-1-phosphate signaling in lung diseases. |
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Pharmacol. Ther. |
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Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis. |
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Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection. |
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Pathog Dis |
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Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis. |
2016 |
Sci Signal |
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Tumor microenvironment on the move and the Aselli connection. |
2016 |
Sci Signal |
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Harijith A et al. |
Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium. |
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Am. J. Physiol. Lung Cell Mol. Physiol. |
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Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation. |
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Gen. Comp. Endocrinol. |
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Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease. |
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Curr Alzheimer Res |
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Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation. |
2016 |
Drugs |
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Sphingosine Kinases: Emerging Structure-Function Insights. |
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Trends Biochem. Sci. |
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Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion. |
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Inflamm. Res. |
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Potential serum biomarkers from a metabolomics study of autism. |
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J Psychiatry Neurosci |
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Sphingosine 1-phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons. |
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Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances. |
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Prog. Lipid Res. |
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Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential. |
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Mediators Inflamm. |
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Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection. |
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Arterioscler. Thromb. Vasc. Biol. |
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S1P prophylaxis mitigates acute hypobaric hypoxia-induced molecular, biochemical, and metabolic disturbances: A preclinical report. |
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IUBMB Life |
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Sphingosine 1-phospate differentially modulates maturation and function of human Langerhans-like cells. |
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J. Dermatol. Sci. |
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The influence of metal-based biomaterials functionalized with sphingosine-1-phosphate on the cellular response and osteogenic differentaion potenial of human adipose derived mesenchymal stem cells in vitro. |
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J Biomater Appl |
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Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720. |
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Novel biological markers of bone: from bone metabolism to bone physiology. |
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Rheumatology (Oxford) |
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Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages. |
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PLoS ONE |
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S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells. |
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Integrated sphingosine-1 phosphate signaling in the central nervous system: From physiological equilibrium to pathological damage. |
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Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43. |
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Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION. |
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Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling. |
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Mol. Cell. Biol. |
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Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling. |
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Cell. Signal. |
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Ratajczak MZ and Suszynska M |
Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells. |
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Stem Cell Rev |
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Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cells. |
2016 |
Exp. Biol. Med. (Maywood) |
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Setoguchi R |
IL-15 boosts the function and migration of human terminally differentiated CD8+ T cells by inducing a unique gene signature. |
2016 |
Int. Immunol. |
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The effect of sphingosine-1-phosphate on bone metabolism in humans depends on its plasma/bone marrow gradient. |
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J. Endocrinol. Invest. |
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Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function. |
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Cardiovasc. Res. |
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Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation. |
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Biochim. Biophys. Acta |
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Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival. |
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Cell. Signal. |
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Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension. |
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Cardiovasc. Res. |
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Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. |
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Neurology |
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The role of sphingolipid signalling in diabetes‑associated pathologies (Review). |
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Int. J. Mol. Med. |
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Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. |
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Nature |
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Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking. |
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Sphingosine-1-Phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche. |
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Stem Cells |
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Selective coupling of the S1P receptor subtype to S1P-mediated RhoA activation and cardioprotection. |
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J. Mol. Cell. Cardiol. |
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Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. |
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Annu. Rev. Physiol. |
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Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720. |
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Acta Haematol. |
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Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells. |
2017 |
Biofactors |
pmid:27801960
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Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei. |
2017 |
J. Lipid Res. |
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Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. |
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Gastroenterology |
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Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer. |
2017 |
J. Surg. Res. |
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"Dicing and Splicing" Sphingosine Kinase and Relevance to Cancer. |
2017 |
Int J Mol Sci |
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Effects of apolipoprotein M in uremic atherosclerosis. |
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Atherosclerosis |
pmid:28866363
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Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation. |
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Mediators Inflamm. |
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Determination of Sphingosine-1-Phosphate in Human Plasma Using Liquid Chromatography Coupled with Q-Tof Mass Spectrometry. |
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Int J Mol Sci |
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An engineered S1P chaperone attenuates hypertension and ischemic injury. |
2017 |
Sci Signal |
pmid:28811382
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S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1 or Lipocalin-2. |
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Mediators Inflamm. |
pmid:28804221
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Acid ceramidase confers radioresistance to glioblastoma cells. |
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Oncol. Rep. |
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Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies. |
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J. Recept. Signal Transduct. Res. |
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Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. |
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J. Mol. Cell. Cardiol. |
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Pleiotropic effects of sphingosine-1-phosphate signaling to control human chorionic mesenchymal stem cell physiology. |
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Cell Death Dis |
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Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. |
2017 |
Bone |
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Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. |
2017 |
Mol Oncol |
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Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. |
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Front Immunol |
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Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. |
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Mol. Pharmacol. |
pmid:28031332
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Sphingosine-1-phosphate activates the AKT pathway to inhibit chemotherapy induced human granulosa cell apoptosis. |
2017 |
Gynecol. Endocrinol. |
pmid:28277139
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Garnero P |
The Utility of Biomarkers in Osteoporosis Management. |
2017 |
Mol Diagn Ther |
pmid:28271451
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Endothelial glycocalyx as a critical signalling platform integrating the extracellular haemodynamic forces and chemical signalling. |
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J. Cell. Mol. Med. |
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Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis. |
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Nephrol. Dial. Transplant. |
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Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications. |
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Hum. Mutat. |
pmid:28181337
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Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania. |
2017 |
Clin. Chim. Acta |
pmid:28159438
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Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? |
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Shock |
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Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. |
2017 |
Front Biosci (Landmark Ed) |
pmid:27814635
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The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. |
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Clin. Cancer Res. |
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High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. |
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Atherosclerosis |
pmid:28038379
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Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices. |
2017 |
PLoS ONE |
pmid:29136008
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Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. |
2017 |
PLoS ONE |
pmid:29112690
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Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication. |
2017 |
PLoS ONE |
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Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. |
2017 |
Exp. Mol. Pathol. |
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Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. |
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J. Endocrinol. |
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Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway. |
2017 |
Cell. Physiol. Biochem. |
pmid:28934733
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Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. |
2017 |
Mol. Immunol. |
pmid:28846923
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Nicholas SE et al. |
Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. |
2017 |
PLoS ONE |
pmid:28806736
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Lee SY et al. |
Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. |
2017 |
Diabetes |
pmid:28698261
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Turner VM and Mabbott NA |
Ageing adversely affects the migration and function of marginal zone B cells. |
2017 |
Immunology |
pmid:28369800
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Müller J et al. |
Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration. |
2017 |
Biomed Res Int |
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Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. |
2017 |
Gastroenterology |
pmid:28363640
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Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease. |
2017 |
Int J Mol Sci |
pmid:28362332
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Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Without Diabetes Mellitus to Activate eNOS: Correction by S1P Enrichment. |
2017 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:28360087
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Gusman DH and Shoemake C |
Evaluation and Optimization of designed Sphingosine-1-Phosphate (S1P) Receptor Subtype 1 Modulators for the Management of Multiple Sclerosis. |
2017 |
Yale J Biol Med |
pmid:28356890
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Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. |
2017 |
Sci Signal |
pmid:28351953
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Becker S et al. |
Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. |
2017 |
PLoS ONE |
pmid:28334008
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Karunakaran I and van Echten-Deckert G |
Sphingosine 1-phosphate - A double edged sword in the brain. |
2017 |
Biochim. Biophys. Acta |
pmid:28315304
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A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. |
2017 |
J Pharm Biomed Anal |
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Sphingosine-1-phosphate induces Ca signaling and CXCL1 release via TRPC6 channel in astrocytes. |
2017 |
Glia |
pmid:28300348
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Dyckman AJ |
Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P) Agonists and Future Perspectives. |
2017 |
J. Med. Chem. |
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