| MeSH term | MeSH ID | Detail |
|---|---|---|
| Influenza, Human | D007251 | 11 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Mycobacterium Infections, Nontuberculous | D009165 | 8 associated lipids |
| Cardiomyopathies | D009202 | 10 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li Y et al. | Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling. | 2004 | Exp. Cell Res. | pmid:15242766 |
| Takeya H | ['Vegetable wasps and plant worms' and G-protein-coupled receptors]. | 2004 | J. UOEH | pmid:15244075 |
| Maupas-Schwalm F et al. | The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator. | 2004 | FASEB J. | pmid:15231724 |
| Fujita T et al. | Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1. | 2004 | Biochem. J. | pmid:15193146 |
| Harada J et al. | Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells. | 2004 | J. Neurochem. | pmid:14756825 |
| Matloubian M et al. | Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. | 2004 | Nature | pmid:14737169 |
| Monick MM et al. | Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:14742298 |
| Kim DS et al. | Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. | 2004 | Cell. Signal. | pmid:14607279 |
| Usui S et al. | Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. | 2004 | J. Biol. Chem. | pmid:14711826 |
| Levkau B et al. | High-density lipoprotein stimulates myocardial perfusion in vivo. | 2004 | Circulation | pmid:15545521 |
| Hale JJ et al. | A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. | 2004 | J. Med. Chem. | pmid:15615513 |
| Lee C et al. | Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition. | 2004 | J Trauma | pmid:15580017 |
| Ochi S et al. | Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes. | 2004 | J. Biol. Chem. | pmid:14702348 |
| Tanimoto T et al. | Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. | 2004 | Circ. Res. | pmid:15044318 |
| Lockman K et al. | Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors. | 2004 | J. Biol. Chem. | pmid:15292266 |
| Nosi D et al. | Effects of S1P on myoblastic cell contraction: possible involvement of Ca-independent mechanisms. | 2004 | Cells Tissues Organs (Print) | pmid:15655330 |
| Yu N et al. | Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes. | 2004 | Glia | pmid:14648542 |
| Formigli L et al. | Sphingosine 1-phosphate induces cell contraction via calcium-independent/Rho-dependent pathways in undifferentiated skeletal muscle cells. | 2004 | J. Cell. Physiol. | pmid:14584038 |
| Argraves KM et al. | Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis. | 2004 | J. Biol. Chem. | pmid:15377653 |
| Grey A et al. | Osteoblastic cells express phospholipid receptors and phosphatases and proliferate in response to sphingosine-1-phosphate. | 2004 | Calcif. Tissue Int. | pmid:15354862 |
| Clemens JJ et al. | Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15341948 |
| Melendez AJ and Ibrahim FB | Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis. | 2004 | J. Immunol. | pmid:15265887 |
| Ikeda H et al. | Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15240112 |
| Misasi R et al. | Prosaposin: a new player in cell death prevention of U937 monocytic cells. | 2004 | Exp. Cell Res. | pmid:15242760 |
| Waeber C et al. | Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors. | 2004 Jul-Aug | Drug News Perspect. | pmid:15334188 |
| Perez GI et al. | A central role for ceramide in the age-related acceleration of apoptosis in the female germline. | 2005 | FASEB J. | pmid:15728664 |
| Damirin A et al. | Sphingosine 1-phosphate receptors mediate the lipid-induced cAMP accumulation through cyclooxygenase-2/prostaglandin I2 pathway in human coronary artery smooth muscle cells. | 2005 | Mol. Pharmacol. | pmid:15625281 |
| Vessey DA et al. | A rapid radioassay for sphingosine kinase. | 2005 | Anal. Biochem. | pmid:15649386 |
| van Meeteren LA et al. | Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. | 2005 | J. Biol. Chem. | pmid:15769751 |
| Huang WR et al. | [Effects of sphingosine 1-phosphate on functions of T cell - review]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:16129068 |
| Saini HS et al. | Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. | 2005 | J. Neurochem. | pmid:16313513 |
| Armulik A et al. | Endothelial/pericyte interactions. | 2005 | Circ. Res. | pmid:16166562 |
| Pchejetski D et al. | Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models. | 2005 | Cancer Res. | pmid:16357178 |
| Mehta D et al. | Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells. | 2005 | J. Biol. Chem. | pmid:15728185 |
| Formigli L et al. | Sphingosine 1-phosphate induces cytoskeletal reorganization in C2C12 myoblasts: physiological relevance for stress fibres in the modulation of ion current through stretch-activated channels. | 2005 | J. Cell. Sci. | pmid:15728255 |
| Minnear FL et al. | Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15778280 |
| Inagaki Y et al. | Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors. | 2005 | Biochem. J. | pmid:15733055 |
| Ohmori T et al. | The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca2+ mobilization in platelets. | 2005 | Thromb. Res. | pmid:15733975 |
| Murakami T et al. | Synthesis and biological properties of novel sphingosine derivatives. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15686924 |
| Edsbagge J et al. | Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. | 2005 | Development | pmid:15689381 |
| Budnik LT and Brunswig-Spickenheier B | Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor. | 2005 | J. Lipid Res. | pmid:15716590 |
| Duan HF et al. | [Establishment of a method for determining the sphingosine kinase activity and its initial application]. | 2005 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21180179 |
| Yin Z and Watsky MA | Chloride channel activity in human lung fibroblasts and myofibroblasts. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15681397 |
| Radeke HH et al. | Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52. | 2005 | J. Immunol. | pmid:15728487 |
| Segura BJ et al. | Sphingosine-1-phosphate induces early response gene expression in C6 glioma cells. | 2005 | Brain Res. Mol. Brain Res. | pmid:15710251 |
| Osawa Y et al. | Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. | 2005 | J. Biol. Chem. | pmid:15946935 |
| Clemens JJ et al. | Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15982878 |
| Zaslavsky A et al. | Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells. | 2005 | FEBS Lett. | pmid:15987639 |
| Chae SS and Hla T | Inhibition of gene expression in vivo using multiplex siRNA. | 2005 | Methods Mol. Biol. | pmid:15990401 |
| Berdyshev EV et al. | Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15766719 |