| MeSH term | MeSH ID | Detail |
|---|---|---|
| Influenza, Human | D007251 | 11 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Mycobacterium Infections, Nontuberculous | D009165 | 8 associated lipids |
| Cardiomyopathies | D009202 | 10 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tanski W et al. | Sphingosine-1-phosphate induces G(alphai)-coupled, PI3K/ras-dependent smooth muscle cell migration. | 2002 | J. Surg. Res. | pmid:12443721 |
| Osada M et al. | Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12445827 |
| Grey A et al. | The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase. | 2002 | Endocrinology | pmid:12446603 |
| Ghelli A et al. | Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta. | 2002 | Biochem. J. | pmid:12014986 |
| Auge N et al. | Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12482824 |
| Nava VE et al. | Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. | 2002 | Exp. Cell Res. | pmid:12441135 |
| Benaud CM et al. | Deregulated activation of matriptase in breast cancer cells. | 2002 | Clin. Exp. Metastasis | pmid:12498394 |
| Maceyka M et al. | Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. | 2002 | Biochim. Biophys. Acta | pmid:12531554 |
| Chin TY et al. | Distinct effects of different calcium-mobilizing agents on cell death in NG108-15 neuroblastoma X glioma cells. | 2002 | Mol. Pharmacol. | pmid:11854428 |
| Weiner OD | Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. | 2002 | Curr. Opin. Cell Biol. | pmid:11891119 |
| Meacci E et al. | Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors. | 2002 | Biochem. J. | pmid:11853542 |
| Lee M and Han SS | Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras--phosphatidylinositol-3-kinase pathway. | 2002 | Cell. Signal. | pmid:11858945 |
| English D | Do platelet-released phospholipids play a role in cardiovascular malformations and heritable coangulopathies? | 2002 | Teratology | pmid:11877771 |
| Boguslawski G et al. | Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response. | 2002 | Exp. Cell Res. | pmid:11900487 |
| Hanafusa N et al. | Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. | 2002 | Nephrol. Dial. Transplant. | pmid:11917049 |
| Idzko M et al. | Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. | 2002 | FASEB J. | pmid:11919175 |
| Mandala S et al. | Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. | 2002 | Science | pmid:11923495 |
| Ancellin N et al. | Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. | 2002 | J. Biol. Chem. | pmid:11741921 |
| Benaud C et al. | Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. | 2002 | J. Biol. Chem. | pmid:11792696 |
| Wang J et al. | Receptor-mediated activation of a Cl(-) current by LPA and S1P in cultured corneal keratocytes. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12356825 |
| Van Brocklyn J et al. | Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. | 2002 | Cancer Lett. | pmid:12175535 |
| Birbes H et al. | Mitochondria and ceramide: intertwined roles in regulation of apoptosis. | 2002 | Adv. Enzyme Regul. | pmid:12123710 |
| Johnson KR et al. | PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). | 2002 | J. Biol. Chem. | pmid:12124383 |
| Thamilselvan V et al. | Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism. | 2002 | In Vitro Cell. Dev. Biol. Anim. | pmid:12197778 |
| Okajima F | [Distribution of sphingosine 1-phosphate in plasma lipoproteins and its role in the regulation of the vascular cell functions]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915346 |
| Yatomi Y et al. | [Sphingosine 1-phosphate and vascular endothelial cells]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915347 |
| Takuwa Y | [Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915348 |
| Tsukahara T et al. | [Molecular diversity of sphingosine kinase]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915350 |
| Kim DS et al. | Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. | 2002 | Cell. Signal. | pmid:12034359 |
| Rikitake Y et al. | Involvement of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:11788469 |
| Pyne S | Cellular signaling by sphingosine and sphingosine 1-phosphate. Their opposing roles in apoptosis. | 2002 | Subcell. Biochem. | pmid:12037985 |
| Graeler M et al. | Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate. | 2002 | J. Immunol. | pmid:12370333 |
| Takuwa Y et al. | The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities. | 2002 | J. Biochem. | pmid:12038970 |
| Meacci E et al. | A role for calcium in sphingosine 1-phosphate-induced phospholipase D activity in C2C12 myoblasts. | 2002 | FEBS Lett. | pmid:12067705 |
| Le Stunff H et al. | Sphingosine-1-phosphate and lipid phosphohydrolases. | 2002 | Biochim. Biophys. Acta | pmid:12069805 |
| Kluk MJ and Hla T | Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069812 |
| Siehler S and Manning DR | Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069815 |
| Takuwa Y | Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069818 |
| Pyne S and Pyne NJ | Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069819 |
| Okajima F | Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator? | 2002 | Biochim. Biophys. Acta | pmid:12069820 |
| Meyer zu Heringdorf D et al. | Sphingosylphosphorylcholine-biological functions and mechanisms of action. | 2002 | Biochim. Biophys. Acta | pmid:12069827 |
| Tanimoto T et al. | Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). | 2002 | J. Biol. Chem. | pmid:12226078 |
| Porcelli AM et al. | Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells. | 2002 | Cell. Signal. | pmid:11747992 |
| Baudhuin LM et al. | Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific. | 2002 | Mol. Pharmacol. | pmid:12181443 |
| Wang S et al. | Two forms of membrane-bound sphingosine kinase in Tetrahymena and activity changes during growth and the cell cycle. | 2002 Jul-Aug | J. Eukaryot. Microbiol. | pmid:12188220 |
| Young KW and Nahorski SR | Sphingosine 1-phosphate: a Ca2+ release mediator in the balance. | 2002 Nov-Dec | Cell Calcium | pmid:12543093 |
| Rábano M et al. | Sphingosine-1-phosphate stimulates cortisol secretion. | 2003 | FEBS Lett. | pmid:12560086 |
| Florio T et al. | Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis. | 2003 | Mol. Pharmacol. | pmid:12527801 |
| Cho H et al. | The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling. | 2003 | Biochem. J. | pmid:12564955 |
| Jin Y et al. | Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. | 2003 | Blood | pmid:12586615 |
| Dziak R et al. | Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591009 |
| Perry DK and Kolesnick RN | Ceramide and sphingosine 1-phosphate in anti-cancer therapies. | 2003 | Cancer Treat. Res. | pmid:12613204 |
| Johnson KR et al. | Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. | 2003 | J. Biol. Chem. | pmid:12815058 |
| Deroanne C et al. | EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. | 2003 | J. Cell. Sci. | pmid:12615978 |
| Fueller M et al. | Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate. | 2003 | Cell. Signal. | pmid:12618211 |
| Niedernberg A et al. | Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. | 2003 | Cell. Signal. | pmid:12618218 |
| Honig SM et al. | FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. | 2003 | J. Clin. Invest. | pmid:12618517 |
| Pacheco YM et al. | Sphingosine 1-phosphate signal survival and mitogenesis are mediated by lipid-stereospecific binding of triacylglycerol-rich lipoproteins. | 2003 | Cell. Mol. Life Sci. | pmid:14685698 |
| Kohno T and Igarashi Y | Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1/S1P1 receptor. | 2003 | J. Biochem. | pmid:14688232 |
| Jeng YJ et al. | Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids. | 2003 | Endocrinology | pmid:12488330 |
| Rosenfeldt HM et al. | Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. | 2003 | FASEB J. | pmid:14519658 |
| Deutschman DH et al. | Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate. | 2003 | Am. Heart J. | pmid:12851609 |
| Burnett C and Howard K | Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo. | 2003 | EMBO Rep. | pmid:12856002 |
| Laychock SG et al. | Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. | 2003 | Diabetes | pmid:12882914 |
| Sauer B et al. | Antiapoptotic action of 1alpha,25-dihydroxyvitamin D3 in primary human melanocytes. | 2003 | Melanoma Res. | pmid:12883359 |
| Pettus BJ et al. | The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. | 2003 | FASEB J. | pmid:12890694 |
| Gratzinger D et al. | Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. | 2003 | FASEB J. | pmid:12890700 |
| Muraki K and Imaizumi Y | A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. | 2003 | J. Pharmacol. Sci. | pmid:12890891 |
| Annabi B et al. | Matrix metalloproteinase regulation of sphingosine-1-phosphate-induced angiogenic properties of bone marrow stromal cells. | 2003 | Exp. Hematol. | pmid:12842709 |
| Djanani A et al. | Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes. | 2003 | Regul. Pept. | pmid:12972327 |
| Bencini C et al. | Effects of sphingosine 1-phosphate on excitation-contraction coupling in mammalian skeletal muscle. | 2003 | J. Muscle Res. Cell. Motil. | pmid:14870969 |
| Facchinetti MM et al. | Differential branching of the sphingolipid metabolic pathways with the stage of development. Involvement of sphingosine kinase. | 2003 | Biol. Neonate | pmid:14504448 |
| Clemens JJ et al. | Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14505636 |
| Shikata Y et al. | Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT. | 2003 | FASEB J. | pmid:14656986 |
| Niedernberg A et al. | Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. | 2003 | J Biomol Screen | pmid:14567777 |
| Rao TS et al. | Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. | 2003 | Brain Res. | pmid:14568343 |
| Sorensen SD et al. | Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. | 2003 | Mol. Pharmacol. | pmid:14573770 |
| Spiegel S and Milstien S | Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways. | 2003 | Biochem. Soc. Trans. | pmid:14641029 |
| Ignatov A et al. | Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14592418 |
| Kim DS et al. | Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis. | 2003 | Arch. Pharm. Res. | pmid:14560924 |
| Coussin F et al. | Sphingosine 1-phosphate induces CREB activation in rat cerebral artery via a protein kinase C-mediated inhibition of voltage-gated K+ channels. | 2003 | Biochem. Pharmacol. | pmid:14563496 |
| Banno Y et al. | Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells. | 2003 | Biochem. J. | pmid:12385647 |
| Högback S et al. | Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. | 2003 | Biochem. J. | pmid:12416995 |
| Watterson K et al. | Pleiotropic actions of sphingosine-1-phosphate. | 2003 | Prog. Lipid Res. | pmid:12790117 |
| Bolz SS et al. | Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway. | 2003 | Circulation | pmid:12796138 |
| Kim JI et al. | Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells. | 2003 | J. Biol. Chem. | pmid:12796504 |
| Thors B et al. | Inhibition of Akt phosphorylation by thrombin, histamine and lysophosphatidylcholine in endothelial cells. Differential role of protein kinase C. | 2003 | Atherosclerosis | pmid:12801607 |
| Yamaguchi H et al. | Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells. | 2003 | Biochem. J. | pmid:12803545 |
| Miura S et al. | Ras/Raf1-dependent signal in sphingosine-1-phosphate-induced tube formation in human coronary artery endothelial cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12821130 |
| Vogler R et al. | Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. | 2003 | J. Invest. Dermatol. | pmid:12648236 |
| Bollag WB | Paradoxical effects of sphingosine-1-phosphate. | 2003 | J. Invest. Dermatol. | pmid:12648243 |
| Uhlenbrock K et al. | Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. | 2003 | Cell. Physiol. Biochem. | pmid:12649592 |
| Gómez-Muñoz A et al. | Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages. | 2003 | FEBS Lett. | pmid:12650926 |
| Kimura T et al. | High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12775579 |
| Duan HF et al. | [Progress in the study of physiological function of sphingosine 1-phosphate]. | 2003 | Sheng Li Ke Xue Jin Zhan | pmid:12778803 |
| Salomone S et al. | S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate. | 2003 | Eur. J. Pharmacol. | pmid:12782194 |
| Graeler MH et al. | Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes. | 2003 | J. Biol. Chem. | pmid:12782628 |
| Van Brocklyn JR et al. | Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells. | 2003 | Cancer Lett. | pmid:12963123 |
| Olivera A et al. | Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. | 2003 | J. Biol. Chem. | pmid:12963721 |
| Rosen H and Liao J | Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. | 2003 | Curr Opin Chem Biol | pmid:12941420 |