Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

Cross Reference

Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Influenza, Human D007251 11 associated lipids
Insulin Resistance D007333 99 associated lipids
Insulinoma D007340 28 associated lipids
Leukemia D007938 74 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Lung Neoplasms D008175 171 associated lipids
Melanoma D008545 69 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Cardiomyopathies D009202 10 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Nerve Degeneration D009410 53 associated lipids
Neuralgia D009437 28 associated lipids
Neuroblastoma D009447 66 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Ovarian Diseases D010049 5 associated lipids
Pain D010146 64 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Per page 10 20 50 100 | Total 2896
Authors Title Published Journal PubMed Link
Radi ZA and Vogel MW Gastric parietal cell atrophy and depletion after administration of a sphingosine-1-phosphate 1 inhibitor. 2014 Toxicol Pathol pmid:24178572
Che W et al. Corticosteroids inhibit sphingosine 1-phosphate-induced interleukin-6 secretion from human airway smooth muscle via mitogen-activated protein kinase phosphatase 1-mediated repression of mitogen and stress-activated protein kinase 1. 2014 Am. J. Respir. Cell Mol. Biol. pmid:24032470
Chang N et al. Sphingosine 1-phosphate receptors negatively regulate collagen type I/III expression in human bone marrow-derived mesenchymal stem cell. 2014 J. Cell. Biochem. pmid:24038457
Völzke A et al. Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. 2014 Biochim. Biophys. Acta pmid:24064301
Pyne NJ et al. The role of sphingosine 1-phosphate in inflammation and cancer. 2014 Adv Biol Regul pmid:24070975
Zhang Y et al. Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. 2014 J. Clin. Invest. pmid:24837436
Kurano M et al. Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate. 2014 Biochim. Biophys. Acta pmid:24814049
Arya D et al. Sphingosine-1-phosphate promotes the differentiation of adipose-derived stem cells into endothelial nitric oxide synthase (eNOS) expressing endothelial-like cells. 2014 J. Biomed. Sci. pmid:24898615
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Nagata Y et al. Sphingosine-1-phosphate mediates epidermal growth factor-induced muscle satellite cell activation. 2014 Exp. Cell Res. pmid:24960577
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Moxon JV et al. Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease. 2014 Circ Cardiovasc Genet pmid:24448739
Gorlino CV et al. Neutrophils exhibit differential requirements for homing molecules in their lymphatic and blood trafficking into draining lymph nodes. 2014 J. Immunol. pmid:25015824
Uhlig S et al. Differential regulation of lung endothelial permeability in vitro and in situ. 2014 Cell. Physiol. Biochem. pmid:24977477
Anderson G and Maes M Reconceptualizing adult neurogenesis: role for sphingosine-1-phosphate and fibroblast growth factor-1 in co-ordinating astrocyte-neuronal precursor interactions. 2014 CNS Neurol Disord Drug Targets pmid:24040808
Nagamatsu T et al. Emerging roles for lysophospholipid mediators in pregnancy. 2014 Am. J. Reprod. Immunol. pmid:24689547
Shimizu Y et al. Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin. 2014 Am. J. Pathol. pmid:24641902
Takeo T et al. Investigations of motility and fertilization potential in thawed cryopreserved mouse sperm from cold-stored epididymides. 2014 Cryobiology pmid:24201107
de Assuncao TM et al. New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. 2014 J. Biol. Chem. pmid:24759103
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Huang K et al. AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose. 2014 Cell. Signal. pmid:24342046
Slattum G et al. Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P. 2014 Curr. Biol. pmid:24361067
Miller DS Sphingolipid signaling reduces basal P-glycoprotein activity in renal proximal tubule. 2014 J. Pharmacol. Exp. Ther. pmid:24385389
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Ito K et al. Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24516133
Nakajima C et al. The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. 2014 Development pmid:25377550
Takeshita E et al. Diacylglycerol kinase γ is a novel anionic phospholipid binding protein with a selective binding preference. 2014 Biochem. Biophys. Res. Commun. pmid:24486543
Barnes J and Dweik RA Is pulmonary hypertension a metabolic disease? 2014 Am. J. Respir. Crit. Care Med. pmid:25360726
Kamiya T et al. Role of Ca2+ -dependent and Ca2+ -sensitive mechanisms in sphingosine 1-phosphate-induced constriction of isolated porcine retinal arterioles in vitro. 2014 Exp. Eye Res. pmid:24486793
Chen J et al. Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. 2014 PLoS Genet. pmid:25356849
Plano D et al. Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors. 2014 J. Med. Chem. pmid:24471412
Degagné E et al. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. 2014 J. Clin. Invest. pmid:25347472
Wang F and Ye P Improving heart function by modulating myocardiocyte autophagy: a possible novel mechanism for cardiovascular protection of high-density lipoprotein. 2014 Lipids Health Dis pmid:25339382
Keller J et al. Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts. 2014 Nat Commun pmid:25333900
Lepletier A et al. Early double-negative thymocyte export in Trypanosoma cruzi infection is restricted by sphingosine receptors and associated with human chagas disease. 2014 PLoS Negl Trop Dis pmid:25330249
Bradley E et al. Critical role of Spns2, a sphingosine-1-phosphate transporter, in lung cancer cell survival and migration. 2014 PLoS ONE pmid:25330231
Xu H et al. Sphingosine-1-phosphate receptor agonist, FTY720, restores coronary flow reserve in diabetic rats. 2014 Circ. J. pmid:25319164
Fukui H et al. S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. 2014 Dev. Cell pmid:25313964
Sutter I et al. Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate. 2014 J. Lipid Res. pmid:24950692
Hanson MA and Peach R Structural biology of the S1P1 receptor. 2014 Curr. Top. Microbiol. Immunol. pmid:24728592
Cahalan SM Chemical and genetic tools to explore S1P biology. 2014 Curr. Top. Microbiol. Immunol. pmid:24728593
Arnon TI and Cyster JG Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen. 2014 Curr. Top. Microbiol. Immunol. pmid:24728595
Oldstone MB and Rosen H Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule. 2014 Curr. Top. Microbiol. Immunol. pmid:24728596
Martin R and Sospedra M Sphingosine-1 phosphate and central nervous system. 2014 Curr. Top. Microbiol. Immunol. pmid:24728597
Kong Y et al. Sphingosine-1-phosphate/S1P receptors signaling modulates cell migration in human bone marrow-derived mesenchymal stem cells. 2014 Mediators Inflamm. pmid:25147438
Shayegi N et al. CXCR4 blockade and sphingosine-1-phosphate activation facilitate engraftment of haematopoietic stem and progenitor cells in a non-myeloablative transplant model. 2014 Br. J. Haematol. pmid:24180707
Nagahashi M et al. Sphingosine-1-phosphate transporters as targets for cancer therapy. 2014 Biomed Res Int pmid:25133174
Nguyen AV et al. STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. 2014 World J. Gastroenterol. pmid:25132744
Kim ES et al. Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression. 2014 Oncogene pmid:23955082
Deng Y et al. Sphingosine Kinase-1/sphingosine 1-phosphate pathway in diabetic nephropathy. 2014 Chin. Med. J. pmid:25131242
Ogle ME et al. Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. 2014 Acta Biomater pmid:25128750
St John AL et al. S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection. 2014 Immunity pmid:25238098
Davis KM and Isberg RR Plague's partners in crime. 2014 Immunity pmid:25238090
Bi Y et al. Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth. 2014 Am. J. Pathol. pmid:25111230
Ishitsuka A et al. FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression. 2014 Int. J. Mol. Med. pmid:25109763
Xiong H et al. SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling. 2014 Oncol. Rep. pmid:25109605
Rolin J and Maghazachi AA Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis. 2014 J. Leukoc. Biol. pmid:24493826
Zhao X et al. Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. 2014 J. Mol. Cell. Cardiol. pmid:25106095
Schwalm S et al. Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. 2014 Basic Clin. Pharmacol. Toxicol. pmid:23789924
Tsai YC et al. Antiapoptotic agent sphingosine-1-phosphate protects vitrified murine ovarian grafts. 2014 Reprod Sci pmid:23793475
Rauch BH Sphingosine 1-phosphate as a link between blood coagulation and inflammation. 2014 Cell. Physiol. Biochem. pmid:24977491
Sattler K et al. HDL-bound sphingosine 1-phosphate (S1P) predicts the severity of coronary artery atherosclerosis. 2014 Cell. Physiol. Biochem. pmid:24977490
Thuy AV et al. Sphingosine 1-phosphate in blood: function, metabolism, and fate. 2014 Cell. Physiol. Biochem. pmid:24977489
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Fayyaz S et al. Divergent role of sphingosine 1-phosphate on insulin resistance. 2014 Cell. Physiol. Biochem. pmid:24977487
Rahman MM et al. Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids. 2014 PLoS ONE pmid:24647471
Halmer R et al. Sphingolipids: important players in multiple sclerosis. 2014 Cell. Physiol. Biochem. pmid:24977485
Park SM et al. Sphingosine-1-phosphate lyase is expressed by CD68+ cells on the parenchymal side of marginal reticular cells in human lymph nodes. 2014 Eur. J. Immunol. pmid:24825162
Arlt O et al. Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo. 2014 Cell. Physiol. Biochem. pmid:24977479
Simmons S and Ishii M Sphingosine-1-phosphate: a master regulator of lymphocyte egress and immunity. 2014 Arch. Immunol. Ther. Exp. (Warsz.) pmid:24276789
Don AS et al. Re-configuration of sphingolipid metabolism by oncogenic transformation. 2014 Biomolecules pmid:24970218
Snelder N et al. Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation. 2014 Drug Metab. Dispos. pmid:24965813
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Potì F et al. Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P). 2014 Cardiovasc. Res. pmid:24891400
Chawla S et al. Exogenous sphingosine-1-phosphate boosts acclimatization in rats exposed to acute hypobaric hypoxia: assessment of haematological and metabolic effects. 2014 PLoS ONE pmid:24887065
Shin KO et al. Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. 2014 Arch. Pharm. Res. pmid:24687256
Yu H et al. Sphingosine kinase 1 improves cutaneous wound healing in diabetic rats. 2014 Injury pmid:24685054
Smyth SS et al. Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis. 2014 Arterioscler. Thromb. Vasc. Biol. pmid:24482375
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Zhang J and Song J Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. 2014 Acta Biomater pmid:24631657
Priceman SJ et al. S1PR1 is crucial for accumulation of regulatory T cells in tumors via STAT3. 2014 Cell Rep pmid:24630990
Oizumi A et al. Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate. 2014 PLoS ONE pmid:24586752
Guan Z et al. Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculature. 2014 J. Am. Soc. Nephrol. pmid:24578134
Takabe K and Spiegel S Export of sphingosine-1-phosphate and cancer progression. 2014 J. Lipid Res. pmid:24474820
Ishizawa S et al. Sphingosine-1-phosphate induces differentiation of cultured renal tubular epithelial cells under Rho kinase activation via the S1P2 receptor. 2014 Clin. Exp. Nephrol. pmid:24463961
Couttas TA et al. Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis. 2014 Acta Neuropathol Commun pmid:24456642
Gassowska M et al. Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells. 2014 Neurochem. Res. pmid:24452756
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Abu El-Asrar AM et al. Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy. 2014 Lipids Health Dis pmid:25496321
Jensen T et al. The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. 2014 Bioorg. Med. Chem. Lett. pmid:25442311
Ye C et al. Identification of a novel small-molecule agonist for human G protein-coupled receptor 3. 2014 J. Pharmacol. Exp. Ther. pmid:24633425
Pyszko J and Strosznajder JB Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells. 2014 Mol. Neurobiol. pmid:24399507
Fincher J et al. G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate. 2014 Dev. Neurosci. pmid:25138637
Cencetti F et al. Lysophosphatidic acid stimulates cell migration of satellite cells. A role for the sphingosine kinase/sphingosine 1-phosphate axis. 2014 FEBS J. pmid:25131845
Neuber C et al. Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. 2014 Anal. Chem. pmid:25137547
Ratajczak MZ et al. The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and cancer cells. 2014 Expert Opin. Ther. Targets pmid:24188167
Chawla S et al. Exogenous sphingosine 1-phosphate protects murine splenocytes against hypoxia-induced injury. 2014 Lipids pmid:24190514