Price MM et al. |
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. |
2013 |
J. Allergy Clin. Immunol. |
pmid:22939756
|
Garris CS et al. |
Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. |
2013 |
Nat. Immunol. |
pmid:24076635
|
Kimizuka K et al. |
Sphingosine 1-phosphate (S1P) induces S1P2 receptor-dependent tonic contraction in murine iliac lymph vessels. |
2013 |
Microcirculation |
pmid:22913344
|
Koch A et al. |
PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. |
2013 |
Biochim. Biophys. Acta |
pmid:23906789
|
Herzog BH et al. |
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. |
2013 |
Nature |
pmid:23995678
|
Donati C et al. |
New insights into the role of sphingosine 1-phosphate and lysophosphatidic acid in the regulation of skeletal muscle cell biology. |
2013 |
Biochim. Biophys. Acta |
pmid:22877992
|
Kotani T et al. |
Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor. |
2013 |
Biol. Reprod. |
pmid:23863409
|
Zhao CG et al. |
Sphingosine-1-phosphate is a possible fibrogenic factor in gluteal muscle fibrosis. |
2013 |
Physiol Res |
pmid:23869887
|
Knapp M et al. |
Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction. |
2013 |
Prostaglandins Other Lipid Mediat. |
pmid:24120760
|
Yuan S et al. |
Lipid receptor S1Pâ‚ activation scheme concluded from microsecond all-atom molecular dynamics simulations. |
2013 |
PLoS Comput. Biol. |
pmid:24098103
|
Wirotanseng LN et al. |
Gq rather than G11 preferentially mediates nociceptor sensitization. |
2013 |
Mol Pain |
pmid:24156378
|
Kurek K et al. |
[The role of sphingolipids in selected cardiovascular diseases]. |
2013 |
Postepy Hig Med Dosw (Online) |
pmid:24088546
|
Kowalski GM et al. |
Plasma sphingosine-1-phosphate is elevated in obesity. |
2013 |
PLoS ONE |
pmid:24039766
|
Ohotski J et al. |
Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer. |
2013 |
Int. J. Cancer |
pmid:22733311
|
Arce FT et al. |
Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. |
2013 |
Nanomedicine |
pmid:23523769
|
Chan H and Pitson SM |
Post-translational regulation of sphingosine kinases. |
2013 |
Biochim. Biophys. Acta |
pmid:22801036
|
Orr Gandy KA and Obeid LM |
Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors. |
2013 |
Biochim. Biophys. Acta |
pmid:22801037
|
Herr DR et al. |
Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. |
2013 |
J. Biol. Chem. |
pmid:24003216
|
Dave JM et al. |
Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). |
2013 |
J. Biol. Chem. |
pmid:24005669
|
Deng H et al. |
Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis. |
2013 |
ACS Med Chem Lett |
pmid:24900589
|
Zhang W et al. |
Sphingosine-1-phosphate receptor-2 mediated NFκB activation contributes to tumor necrosis factor-α induced VCAM-1 and ICAM-1 expression in endothelial cells. |
2013 |
Prostaglandins Other Lipid Mediat. |
pmid:23770055
|
Southern C et al. |
Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. |
2013 |
J Biomol Screen |
pmid:23396314
|
Selhub J et al. |
Dietary vitamin B6 intake modulates colonic inflammation in the IL10-/- model of inflammatory bowel disease. |
2013 |
J. Nutr. Biochem. |
pmid:24183308
|
Wang X et al. |
Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. |
2013 |
Biochem. Pharmacol. |
pmid:24134913
|
Brewer JW |
Phospholipids: "greasing the wheels" of humoral immunity. |
2013 |
Biochim. Biophys. Acta |
pmid:23051607
|
Ishii M and Kikuta J |
Sphingosine-1-phosphate signaling controlling osteoclasts and bone homeostasis. |
2013 |
Biochim. Biophys. Acta |
pmid:22691949
|
Ley S et al. |
The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages. |
2013 |
Oncogene |
pmid:22410777
|
Beckham TH et al. |
Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. |
2013 |
PLoS ONE |
pmid:24098536
|
Schwalm S et al. |
Sphingosine-1-phosphate: a Janus-faced mediator of fibrotic diseases. |
2013 |
Biochim. Biophys. Acta |
pmid:22889995
|
Xiong Y et al. |
Sphingosine kinases are not required for inflammatory responses in macrophages. |
2013 |
J. Biol. Chem. |
pmid:24081141
|
Zhang W et al. |
ETS-1-mediated transcriptional up-regulation of CD44 is required for sphingosine-1-phosphate receptor subtype 3-stimulated chemotaxis. |
2013 |
J. Biol. Chem. |
pmid:24064218
|
Babahosseini H et al. |
Bioactive sphingolipid metabolites modulate ovarian cancer cell structural mechanics. |
2013 |
Integr Biol (Camb) |
pmid:24056950
|
Zhang O et al. |
Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence. |
2013 |
Mol. Microbiol. |
pmid:23980754
|
Tran-Dinh A et al. |
HDL and endothelial protection. |
2013 |
Br. J. Pharmacol. |
pmid:23488589
|
Mudd JC et al. |
Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes. |
2013 |
Blood |
pmid:23422746
|
Olivera A et al. |
Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. |
2013 |
J. Leukoc. Biol. |
pmid:23904439
|
Camacho L et al. |
Acid ceramidase as a therapeutic target in metastatic prostate cancer. |
2013 |
J. Lipid Res. |
pmid:23423838
|
Sun X et al. |
Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. |
2013 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:23911438
|
Hardin C et al. |
Glassy dynamics, cell mechanics, and endothelial permeability. |
2013 |
J Phys Chem B |
pmid:23638866
|
Xiang SY et al. |
PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. |
2013 |
Sci Signal |
pmid:24345679
|
Kendig DM et al. |
Sphingosine-1-phosphate induced contraction of bladder smooth muscle. |
2013 |
Eur. J. Pharmacol. |
pmid:24120660
|
Liu Y et al. |
Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors. |
2013 |
J. Pathol. |
pmid:23839903
|
Riccitelli E et al. |
Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival. |
2013 |
PLoS ONE |
pmid:23826381
|
Wang Y et al. |
Epidermal growth factor receptor signaling-dependent calcium elevation in cumulus cells is required for NPR2 inhibition and meiotic resumption in mouse oocytes. |
2013 |
Endocrinology |
pmid:23787120
|
Wang Z et al. |
Molecular basis of sphingosine kinase 1 substrate recognition and catalysis. |
2013 |
Structure |
pmid:23602659
|
Salmanzadeh A et al. |
Sphingolipid metabolites modulate dielectric characteristics of cells in a mouse ovarian cancer progression model. |
2013 |
Integr Biol (Camb) |
pmid:23609351
|
Orr Gandy KA et al. |
Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. |
2013 |
FASEB J. |
pmid:23629860
|
Schneider G et al. |
Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy. |
2013 |
Mol. Cancer Res. |
pmid:23615526
|
Cinq-Frais C et al. |
A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. |
2013 |
Biochim. Biophys. Acta |
pmid:23651497
|
Christoffersen C and Nielsen LB |
Apolipoprotein M: bridging HDL and endothelial function. |
2013 |
Curr. Opin. Lipidol. |
pmid:23652568
|
Egom EE et al. |
HDL quality or cholesterol cargo: what really matters--spotlight on sphingosine-1-phosphate-rich HDL. |
2013 |
Curr. Opin. Lipidol. |
pmid:23652570
|
Lundblad C et al. |
Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat. |
2013 |
Acta Anaesthesiol Scand |
pmid:23683126
|
Kroetsch JT and Bolz SS |
The TNF-α/sphingosine-1-phosphate signaling axis drives myogenic responsiveness in heart failure. |
2013 |
J. Vasc. Res. |
pmid:23594703
|
Allende ML et al. |
Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis. |
2013 |
J. Biol. Chem. |
pmid:23637227
|
Schaper K et al. |
Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis. |
2013 |
J. Dermatol. Sci. |
pmid:23643308
|
Böhm A et al. |
Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells. |
2013 |
Cardiovasc. Res. |
pmid:23658376
|
Kurano M et al. |
Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M. |
2013 |
Atherosclerosis |
pmid:23664237
|
Stradner MH et al. |
Sphingosine 1-phosphate counteracts the effects of interleukin-1β in human chondrocytes. |
2013 |
Arthritis Rheum. |
pmid:23666803
|
Usatyuk PV et al. |
Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction. |
2013 |
PLoS ONE |
pmid:23667561
|
Kim YD et al. |
Effects of sphingosine-1-phosphate on pacemaker activity of interstitial cells of Cajal from mouse small intestine. |
2013 |
Mol. Cells |
pmid:23307289
|
Sharma N et al. |
Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells. |
2013 |
J. Leukoc. Biol. |
pmid:23345392
|
Salvemini D et al. |
Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain. |
2013 |
Trends Pharmacol. Sci. |
pmid:23318139
|
Tibolla G et al. |
Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis. |
2013 |
PLoS ONE |
pmid:23320105
|
Lee YJ et al. |
Sphingosine-1-phosphate protects against bisphosphonate‑induced HUVEC cell death via regulation of c-Jun‑N‑terminal kinase signaling. |
2013 |
Int. J. Mol. Med. |
pmid:23381659
|
Yangyuoru PM et al. |
Fluorescent lipids as probes for sphingosine kinase activity by capillary electrophoresis. |
2013 |
Methods Mol. Biol. |
pmid:23386355
|
Dillahunt SE et al. |
Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined. |
2013 |
J. Immunol. |
pmid:23359503
|
Tong X et al. |
High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate. |
2013 |
Cardiovasc Diabetol |
pmid:23360427
|
Finley A et al. |
Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. |
2013 |
PLoS ONE |
pmid:23372844
|
Gandy KA et al. |
Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. |
2013 |
Biochem. J. |
pmid:23106337
|
Pantoja M et al. |
Genetic elevation of sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila. |
2013 |
Development |
pmid:23154413
|
Carr JM et al. |
Sphingosine kinase 1 in viral infections. |
2013 |
Rev. Med. Virol. |
pmid:22639116
|
Di Menna L et al. |
Fingolimod protects cultured cortical neurons against excitotoxic death. |
2013 |
Pharmacol. Res. |
pmid:23073075
|
Zu Heringdorf DM et al. |
Pharmacology of the sphingosine-1-phosphate signalling system. |
2013 |
Handb Exp Pharmacol |
pmid:23579459
|
Matheu MP et al. |
Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. |
2013 |
PLoS ONE |
pmid:23533579
|
Sobel K et al. |
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. |
2013 |
J. Biol. Chem. |
pmid:23589284
|
Barth BM et al. |
Gaucher's disease and cancer: a sphingolipid perspective. |
2013 |
Crit Rev Oncog |
pmid:23510065
|
Bernhart E et al. |
Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro. |
2013 |
Exp. Cell Res. |
pmid:23562655
|
Selvam SP and Ogretmen B |
Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance. |
2013 |
Handb Exp Pharmacol |
pmid:23563649
|
Pyne S and Pyne NJ |
New perspectives on the role of sphingosine 1-phosphate in cancer. |
2013 |
Handb Exp Pharmacol |
pmid:23563651
|
Jiang XC and Liu J |
Sphingolipid metabolism and atherosclerosis. |
2013 |
Handb Exp Pharmacol |
pmid:23563655
|
Levkau B |
Cardiovascular effects of sphingosine-1-phosphate (S1P). |
2013 |
Handb Exp Pharmacol |
pmid:23563656
|
Abbasi T and Garcia JG |
Sphingolipids in lung endothelial biology and regulation of vascular integrity. |
2013 |
Handb Exp Pharmacol |
pmid:23563658
|
Gandy KA and Obeid LM |
Regulation of the sphingosine kinase/sphingosine 1-phosphate pathway. |
2013 |
Handb Exp Pharmacol |
pmid:23563662
|
Pyne NJ et al. |
Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis. |
2013 |
Biochim. Biophys. Acta |
pmid:22801038
|
Lukowski ZL et al. |
Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (Sonepcizumab) in a rabbit model. |
2013 |
J. Glaucoma |
pmid:21946553
|
O'Sullivan C and Dev KK |
The structure and function of the S1P1 receptor. |
2013 |
Trends Pharmacol. Sci. |
pmid:23763867
|
Chang CH et al. |
Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro. |
2013 |
Acta Pharmacol. Sin. |
pmid:23377549
|
Cuvillier O et al. |
Hypoxia, therapeutic resistance, and sphingosine 1-phosphate. |
2013 |
Adv. Cancer Res. |
pmid:23290779
|
Alshaker H et al. |
Therapeutic potential of targeting SK1 in human cancers. |
2013 |
Adv. Cancer Res. |
pmid:23290780
|
Ohkuni A et al. |
Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway. |
2013 |
Biochem. Biophys. Res. Commun. |
pmid:24269233
|
Heffernan-Stroud LA and Obeid LM |
Sphingosine kinase 1 in cancer. |
2013 |
Adv. Cancer Res. |
pmid:23290781
|
Zhang J et al. |
Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration. |
2013 |
Hum. Reprod. |
pmid:24001716
|
Kihara A |
[Complete metabolic pathway of sphingosine 1-phosphate and its importance as a metabolic intermediate]. |
2013 |
Seikagaku |
pmid:23980469
|
Knapp M et al. |
Dose-dependent effect of aspirin on the level of sphingolipids in human blood. |
2013 |
Adv Med Sci |
pmid:24101372
|
Weichand B et al. |
Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration. |
2013 |
Eur. J. Immunol. |
pmid:23934754
|
Morad SA et al. |
Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells. |
2013 |
Biochim. Biophys. Acta |
pmid:23939396
|
Banitalebi E et al. |
The effect of resistance training on plasma S1P level and gene expression of S1P1,2,3 receptors in male Wistar rats. |
2013 |
Minerva Endocrinol. |
pmid:24285107
|
Rokka J et al. |
19F/18F exchange synthesis for a novel [18F]S1P3-radiopharmaceutical. |
2013 |
J Labelled Comp Radiopharm |
pmid:24285478
|
Kajimoto T et al. |
Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes. |
2013 |
Nat Commun |
pmid:24231649
|
Ito S et al. |
Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes. |
2013 |
Coron. Artery Dis. |
pmid:24212262
|