| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pregnancy, Ectopic | D011271 | 5 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Cardiomyopathies | D009202 | 10 associated lipids |
| Mycobacterium Infections, Nontuberculous | D009165 | 8 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Osawa Y et al. | TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. | 2001 | J. Immunol. | pmid:11418646 |
| Boujaoude LC et al. | Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. | 2001 | J. Biol. Chem. | pmid:11443135 |
| Paik JH et al. | Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. | 2001 | J. Biol. Chem. | pmid:11150298 |
| Meyer zu Heringdorf D et al. | Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. | 2001 | Eur. J. Pharmacol. | pmid:11239914 |
| Young KW and Nahorski SR | Intracellular sphingosine 1-phosphate production: a novel pathway for Ca2+ release. | 2001 | Semin. Cell Dev. Biol. | pmid:11162743 |
| Karliner JS et al. | The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes. | 2001 | J. Mol. Cell. Cardiol. | pmid:11549349 |
| Rosenfeldt HM et al. | EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration. | 2001 | FASEB J. | pmid:11726541 |
| Lampasso JD et al. | Sphingosine-1-phosphate effects on PKC isoform expression in human osteoblastic cells. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728164 |
| Hla T et al. | Lysophospholipids--receptor revelations. | 2001 | Science | pmid:11729304 |
| Muraki K and Imaizumi Y | A novel function of sphingosine-1-phosphate to activate a non-selective cation channel in human endothelial cells. | 2001 | J. Physiol. (Lond.) | pmid:11731576 |
| Lee MJ et al. | Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. | 2001 | Mol. Cell | pmid:11583630 |
| Li G et al. | Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. | 2001 | Development | pmid:11566853 |
| Bischoff A et al. | Nifedipine inhibits sphinogosine-1-phosphate-induced renovascular contraction in vitro and in vivo. | 2001 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:11534858 |
| Robert P et al. | EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. | 2001 | J. Mol. Cell. Cardiol. | pmid:11549339 |
| Marletta MA | Another activation switch for endothelial nitric oxide synthase: why does it have to be so complicated? | 2001 | Trends Biochem. Sci. | pmid:11551775 |
| Erl W and Siess W | Sphingosine-1-phosphate and the leading Edg-1 of vascular smooth muscle cells. | 2001 | Circ. Res. | pmid:11557732 |
| Kluk MJ and Hla T | Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. | 2001 | Circ. Res. | pmid:11557736 |
| Meacci E et al. | Dual regulation of sphingosine 1-phosphate-induced phospholipase D activity through RhoA and protein kinase C-alpha in C2C12 myoblasts. | 2001 | Cell. Signal. | pmid:11483412 |
| Pébay A et al. | Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. | 2001 | Eur. J. Neurosci. | pmid:11467306 |
| Brownlee C | Intracellular signalling: sphingosine-1-phosphate branches out. | 2001 | Curr. Biol. | pmid:11470429 |
| Igarashi J and Michel T | Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways. | 2001 | J. Biol. Chem. | pmid:11470796 |
| Garcia JG et al. | Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. | 2001 | J. Clin. Invest. | pmid:11544274 |
| Nadal A et al. | Glial cell responses to lipids bound to albumin in serum and plasma. | 2001 | Prog. Brain Res. | pmid:11545003 |
| Tamama K et al. | Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells. | 2001 | Biochem. J. | pmid:11115407 |
| Ohanian J and Ohanian V | Sphingolipids in mammalian cell signalling. | 2001 | Cell. Mol. Life Sci. | pmid:11814056 |
| Wang DA et al. | A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors. | 2001 | J. Biol. Chem. | pmid:11604399 |
| Andor A et al. | YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells. | 2001 | Cell. Microbiol. | pmid:11298653 |
| Ammit AJ et al. | Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. | 2001 | FASEB J. | pmid:11344091 |
| Yatomi Y et al. | Sphingosine 1-phosphate: synthesis and release. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324700 |
| Goetzl EJ | Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324701 |
| Olivera A and Spiegel S | Sphingosine kinase: a mediator of vital cellular functions. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324702 |
| Hla T | Sphingosine 1-phosphate receptors. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324703 |
| Mandala SM | Sphingosine-1-phosphate phosphatases. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324704 |
| Lynch KR and Macdonald TL | Structure activity relationships of lysophospholipid mediators. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324706 |
| Panetti TS et al. | Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324710 |
| Alderton F et al. | G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells. | 2001 | J. Biol. Chem. | pmid:11278307 |
| Igarashi J et al. | Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. | 2001 | J. Biol. Chem. | pmid:11278407 |
| Morales-Ruiz M et al. | Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. | 2001 | J. Biol. Chem. | pmid:11278592 |
| Birchwood CJ et al. | Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation. | 2001 | J. Biol. Chem. | pmid:11278643 |
| Ng CK et al. | Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. | 2001 | Nature | pmid:11279499 |
| Kranenburg O and Moolenaar WH | Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. | 2001 | Oncogene | pmid:11313900 |
| Osawa Y et al. | Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11520048 |
| Takuwa Y et al. | Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator. | 2001 | Mol. Cell. Endocrinol. | pmid:11377814 |
| Banno Y et al. | Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3. | 2001 | J. Biol. Chem. | pmid:11468290 |
| Blaukat A and Dikic I | Activation of sphingosine kinase by the bradykinin B2 receptor and its implication in regulation of the ERK/MAP kinase pathway. | 2001 | Biol. Chem. | pmid:11258664 |
| Alemany R et al. | Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. | 2001 | FEBS Lett. | pmid:11741596 |
| Yun JK and Kester M | Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. | 2002 | Arch. Biochem. Biophys. | pmid:12485605 |
| Weiner OD | Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. | 2002 | Curr. Opin. Cell Biol. | pmid:11891119 |
| Jin ZQ et al. | Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12003800 |
| Lampasso JD et al. | Role of protein kinase C alpha in primary human osteoblast proliferation. | 2002 | J. Bone Miner. Res. | pmid:12412804 |