| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pregnancy, Ectopic | D011271 | 5 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Cardiomyopathies | D009202 | 10 associated lipids |
| Mycobacterium Infections, Nontuberculous | D009165 | 8 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cuvillier O | Sphingosine in apoptosis signaling. | 2002 | Biochim. Biophys. Acta | pmid:12531549 |
| Ghelli A et al. | Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta. | 2002 | Biochem. J. | pmid:12014986 |
| Auge N et al. | Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12482824 |
| Nava VE et al. | Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. | 2002 | Exp. Cell Res. | pmid:12441135 |
| Benaud CM et al. | Deregulated activation of matriptase in breast cancer cells. | 2002 | Clin. Exp. Metastasis | pmid:12498394 |
| Maceyka M et al. | Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. | 2002 | Biochim. Biophys. Acta | pmid:12531554 |
| Chin TY et al. | Distinct effects of different calcium-mobilizing agents on cell death in NG108-15 neuroblastoma X glioma cells. | 2002 | Mol. Pharmacol. | pmid:11854428 |
| Gennero I et al. | Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density. | 2002 | J. Biol. Chem. | pmid:11821388 |
| Baumruker T and Prieschl EE | Sphingolipids and the regulation of the immune response. | 2002 | Semin. Immunol. | pmid:11884231 |
| Weiner OD | Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. | 2002 | Curr. Opin. Cell Biol. | pmid:11891119 |
| Meacci E et al. | Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors. | 2002 | Biochem. J. | pmid:11853542 |
| Lee M and Han SS | Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras--phosphatidylinositol-3-kinase pathway. | 2002 | Cell. Signal. | pmid:11858945 |
| English D | Do platelet-released phospholipids play a role in cardiovascular malformations and heritable coangulopathies? | 2002 | Teratology | pmid:11877771 |
| Boguslawski G et al. | Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response. | 2002 | Exp. Cell Res. | pmid:11900487 |
| Hanafusa N et al. | Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. | 2002 | Nephrol. Dial. Transplant. | pmid:11917049 |
| Idzko M et al. | Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. | 2002 | FASEB J. | pmid:11919175 |
| Ancellin N et al. | Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. | 2002 | J. Biol. Chem. | pmid:11741921 |
| Benaud C et al. | Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. | 2002 | J. Biol. Chem. | pmid:11792696 |
| Wang J et al. | Receptor-mediated activation of a Cl(-) current by LPA and S1P in cultured corneal keratocytes. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12356825 |
| Van Brocklyn J et al. | Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. | 2002 | Cancer Lett. | pmid:12175535 |
| Birbes H et al. | Mitochondria and ceramide: intertwined roles in regulation of apoptosis. | 2002 | Adv. Enzyme Regul. | pmid:12123710 |
| Johnson KR et al. | PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). | 2002 | J. Biol. Chem. | pmid:12124383 |
| Thamilselvan V et al. | Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism. | 2002 | In Vitro Cell. Dev. Biol. Anim. | pmid:12197778 |
| Coussin F et al. | Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction. | 2002 | Circ. Res. | pmid:12142348 |
| Wang L et al. | Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells. | 2002 | Biochem. J. | pmid:12149127 |
| Kveberg L et al. | Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases. | 2002 | Eur. J. Immunol. | pmid:12115604 |
| Spiegel S and Kolesnick R | Sphingosine 1-phosphate as a therapeutic agent. | 2002 | Leukemia | pmid:12200669 |
| Paris F et al. | Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. | 2002 | Nat. Med. | pmid:12205432 |
| Davaille J et al. | Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts. | 2002 | J. Biol. Chem. | pmid:12138095 |
| Okazaki T and Ito M | [Signal transduction of ceramide]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915339 |
| Igarashi Y | [Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915345 |
| Okajima F | [Distribution of sphingosine 1-phosphate in plasma lipoproteins and its role in the regulation of the vascular cell functions]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915346 |
| Yatomi Y et al. | [Sphingosine 1-phosphate and vascular endothelial cells]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915347 |
| Takuwa Y | [Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915348 |
| Tsukahara T et al. | [Molecular diversity of sphingosine kinase]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915350 |
| Rikitake Y et al. | Involvement of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:11788469 |
| Graeler M et al. | Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate. | 2002 | J. Immunol. | pmid:12370333 |
| Kluk MJ and Hla T | Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069812 |
| Siehler S and Manning DR | Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069815 |
| Takuwa Y | Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069818 |
| Pyne S and Pyne NJ | Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069819 |
| Okajima F | Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator? | 2002 | Biochim. Biophys. Acta | pmid:12069820 |
| Meyer zu Heringdorf D et al. | Sphingosylphosphorylcholine-biological functions and mechanisms of action. | 2002 | Biochim. Biophys. Acta | pmid:12069827 |
| Panetti TS | Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells. | 2002 | Biochim. Biophys. Acta | pmid:12069828 |
| Siess W | Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate. | 2002 | Biochim. Biophys. Acta | pmid:12069830 |
| Karliner JS | Lysophospholipids and the cardiovascular system. | 2002 | Biochim. Biophys. Acta | pmid:12069831 |
| English D et al. | Lipid mediators of angiogenesis and the signalling pathways they initiate. | 2002 | Biochim. Biophys. Acta | pmid:12069833 |
| Spiegel S et al. | Sphingosine 1-phosphate signaling: providing cells with a sense of direction. | 2002 | Trends Cell Biol. | pmid:12062172 |
| Kohno T et al. | N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. | 2002 | FASEB J. | pmid:12087059 |
| Baudhuin LM et al. | Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific. | 2002 | Mol. Pharmacol. | pmid:12181443 |