MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Pennington LD et al. | Quinolinone-based agonists of S1Pâ‚: use of a N-scan SAR strategy to optimize in vitro and in vivo activity. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22104144 |
Yuan L et al. | [The study on protective effect of sphingosine-1-phosphate in cardiomyocytes]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:22097726 |
Meng H et al. | Loss of sphingosine kinase 1/S1P signaling impairs cell growth and survival of neurons and progenitor cells in the developing sensory ganglia. | 2011 | PLoS ONE | pmid:22096531 |
Park SW et al. | Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury. | 2012 | J. Am. Soc. Nephrol. | pmid:22095950 |
Ishimaru N et al. | CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy. | 2012 | Am. J. Pathol. | pmid:22067914 |
Eichner A and Sixt M | Setting the clock for recirculating lymphocytes. | 2011 | Sci Signal | pmid:22067458 |
Lépine S et al. | Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage. | 2011 | J. Biol. Chem. | pmid:22052905 |
Juarez JG et al. | Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. | 2012 | Blood | pmid:22049516 |
Sola A et al. | Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration. | 2011 | J. Pathol. | pmid:22025214 |
Castillo-Badillo JA et al. | Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions. | 2012 | Biochim. Biophys. Acta | pmid:22019450 |
El-Shewy HM et al. | Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. | 2011 | Mol. Endocrinol. | pmid:22016563 |
Callihan P et al. | Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. | 2012 | Neuropharmacology | pmid:22016110 |
Yester JW et al. | Extracellular and intracellular sphingosine-1-phosphate in cancer. | 2011 | Cancer Metastasis Rev. | pmid:22002715 |
Gomez L et al. | A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection. | 2011 | Basic Res. Cardiol. | pmid:22002221 |
Kang H et al. | Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices. | 2011 | J. Biol. Chem. | pmid:22002053 |
Gupta VK et al. | Focus on molecules: Sphingosine 1 Phosphate (S1P). | 2012 | Exp. Eye Res. | pmid:22001715 |
Maceyka M et al. | Sphingosine-1-phosphate signaling and its role in disease. | 2012 | Trends Cell Biol. | pmid:22001186 |
Lan T et al. | Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells. | 2011 | Mol. Endocrinol. | pmid:21998146 |
Härmä V et al. | Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models. | 2012 | Oncogene | pmid:21996742 |
Su G et al. | Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:21980034 |
Bradley ME et al. | The in vitro metabolism of sphingosine-1-phosphate: identification; inhibition and pharmacological implications. | 2011 | Eur. J. Pharmacol. | pmid:21970805 |
Morel S et al. | The natural cardioprotective particle HDL modulates connexin43 gap junction channels. | 2012 | Cardiovasc. Res. | pmid:21960685 |
Arnon TI et al. | GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. | 2011 | Science | pmid:21960637 |
Lukowski ZL et al. | Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (Sonepcizumab) in a rabbit model. | 2013 | J. Glaucoma | pmid:21946553 |
Karuna R et al. | Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism. | 2011 | Atherosclerosis | pmid:21944699 |
McGuire PG et al. | Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21940944 |
Pyne S et al. | Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules. | 2011 | Cancer Res. | pmid:21940750 |
Blaho VA and Hla T | Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. | 2011 | Chem. Rev. | pmid:21939239 |
Belvitch P and Dudek SM | Role of FAK in S1P-regulated endothelial permeability. | 2012 | Microvasc. Res. | pmid:21925517 |
Duru EA et al. | SRC regulates sphingosine-1-phosphate mediated smooth muscle cell migration. | 2012 | J. Surg. Res. | pmid:21920544 |
Serafimidis I et al. | G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis. | 2011 | Mol. Cell. Biol. | pmid:21911471 |
Hammad SM | Blood sphingolipids in homeostasis and pathobiology. | 2011 | Adv. Exp. Med. Biol. | pmid:21910082 |
Baranowski M and Górski J | Heart sphingolipids in health and disease. | 2011 | Adv. Exp. Med. Biol. | pmid:21910081 |
Edmonds Y et al. | Development of small-molecule inhibitors of sphingosine-1-phosphate signaling. | 2011 | Pharmacol. Ther. | pmid:21906625 |
Yang Y and Uhlig S | The role of sphingolipids in respiratory disease. | 2011 | Ther Adv Respir Dis | pmid:21900155 |
Kim BS et al. | The sphingosine-1-phosphate derivative NHOBTD inhibits angiogenesis both in vitro and in vivo. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21888894 |
Lucki NC and Sewer MB | Nuclear sphingolipid metabolism. | 2012 | Annu. Rev. Physiol. | pmid:21888508 |
Tencé M et al. | Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists. | 2012 | Cell. Signal. | pmid:21872657 |
Qadri SM et al. | Sphingosine but not sphingosine-1-phosphate stimulates suicidal erythrocyte death. | 2011 | Cell. Physiol. Biochem. | pmid:21865742 |
Adyshev DM et al. | Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement. | 2011 | Cell. Signal. | pmid:21864676 |
Lucki NC et al. | Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells. | 2012 | Mol. Cell. Endocrinol. | pmid:21864647 |
Siow D and Wattenberg B | The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism. | 2011 | Crit. Rev. Biochem. Mol. Biol. | pmid:21864225 |
Kharel Y et al. | Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. | 2011 | Biochem. J. | pmid:21848514 |
Huwiler A et al. | A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. | 2011 | PLoS ONE | pmid:21829623 |
Schulze T et al. | Sphingosine-1-phospate receptor 4 (S1Pâ‚„) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model. | 2011 | FASEB J. | pmid:21825036 |
GarcÃa-Sáinz JA et al. | Mechanisms involved in α1B-adrenoceptor desensitization. | 2011 | IUBMB Life | pmid:21815242 |
Obinata H and Hla T | Sphingosine 1-phosphate in coagulation and inflammation. | 2012 | Semin Immunopathol | pmid:21805322 |
Tanfin Z et al. | ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium. | 2011 | Cell. Signal. | pmid:21803151 |
Okamoto Y et al. | [Cardiovascular function of sphingosine 1-phosphate signaling]. | 2011 | Seikagaku | pmid:21800684 |
Gault CR and Obeid LM | Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy. | 2011 | Crit. Rev. Biochem. Mol. Biol. | pmid:21787121 |
Bautista-Pérez R et al. | Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats. | 2011 | Diabetes Res. Clin. Pract. | pmid:21775010 |
Yu Y and Qin SC | [An active lipid signaling molecule: sphingosine-1-phosphate and its biological characteristics]. | 2011 | Sheng Li Ke Xue Jin Zhan | pmid:21770269 |
Murakami M et al. | Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription. | 2011 | J. Cell. Biochem. | pmid:21769916 |
Kim CH et al. | Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors. | 2012 | Leukemia | pmid:21769103 |
Shi Y et al. | Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. | 2012 | J. Hepatol. | pmid:21756852 |
Kim DS et al. | Sphingosine-1-phosphate decreases melanin synthesis via microphthalmia-associated transcription factor phosphorylation through the S1P3 receptor subtype. | 2011 | J. Pharm. Pharmacol. | pmid:21749389 |
Selim S et al. | Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions. | 2011 | Clin. Sci. | pmid:21749329 |
AL-Shawaf E et al. | GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels. | 2011 | Cell Calcium | pmid:21742378 |
Kojima K and Inouye K | Activation of matriptase zymogen. | 2011 | J. Biochem. | pmid:21737400 |
Liu D et al. | Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21734188 |
Spiegel S et al. | Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy. | 2012 | Oncogene | pmid:21725353 |
Olivera A and Rivera J | An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease. | 2011 | Adv. Exp. Med. Biol. | pmid:21713655 |
Mathew B et al. | Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. | 2011 | FASEB J. | pmid:21712494 |
Bourquin F et al. | PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism. | 2011 | Protein Sci. | pmid:21710479 |
Stevenson CE et al. | Targeting sphingosine-1-phosphate in hematologic malignancies. | 2011 | Anticancer Agents Med Chem | pmid:21707492 |
Watters RJ et al. | Targeting sphingosine-1-phosphate receptors in cancer. | 2011 | Anticancer Agents Med Chem | pmid:21707490 |
Weigert A et al. | S1P regulation of macrophage functions in the context of cancer. | 2011 | Anticancer Agents Med Chem | pmid:21707489 |
Bedia C et al. | Regulation of autophagy by sphingolipids. | 2011 | Anticancer Agents Med Chem | pmid:21707487 |
Cuvillier O and Ader I | Hypoxia-inducible factors and sphingosine 1-phosphate signaling. | 2011 | Anticancer Agents Med Chem | pmid:21707486 |
Burns TA and Luberto C | Sphingolipid metabolism and leukemia: a potential for novel therapeutic approaches. | 2011 | Anticancer Agents Med Chem | pmid:21707485 |
Kawahara A | [Genetic dissection of cardiac morphogenesis in zebrafish]. | 2011 | Seikagaku | pmid:21706872 |
Yangyuoru PM et al. | Determination of sphingosine kinase 2 activity using fluorescent sphingosine by capillary electrophoresis. | 2011 | Electrophoresis | pmid:21706498 |
Egom EE et al. | Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21705677 |
Delogu G et al. | Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection. | 2011 | Cell. Immunol. | pmid:21703599 |
Costello RW et al. | Mechanism of sphingosine 1-phosphate- and lysophosphatidic acid-induced up-regulation of adhesion molecules and eosinophil chemoattractant in nerve cells. | 2011 | Int J Mol Sci | pmid:21686182 |
Vessey DA et al. | P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X₇ channels. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21685263 |
Kanno T and Nishizaki T | Endogenous sphingosine 1-phosphate regulates spontaneous glutamate release from mossy fiber terminals via S1P(3) receptors. | 2011 | Life Sci. | pmid:21683714 |
Alden KP et al. | Sphingolipid long chain base phosphates can regulate apoptotic-like programmed cell death in plants. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21683064 |
Varo-Sánchez GM et al. | [Pharmacological targets in multiple sclerosis]. | 2011 | Rev Neurol | pmid:21678322 |
Goetzl EJ et al. | Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia. | 2011 | J. Clin. Immunol. | pmid:21671128 |
Poulsen RR et al. | The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development. | 2011 | BMC Dev. Biol. | pmid:21668976 |
Walzer T and Vivier E | G-protein-coupled receptors in control of natural killer cell migration. | 2011 | Trends Immunol. | pmid:21664184 |
Liu X et al. | Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation. | 2011 | J. Cell. Physiol. | pmid:21660960 |
Kim ES et al. | Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Gαq coupling. | 2011 | J. Cell. Sci. | pmid:21652634 |
Zhao Z et al. | Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions. | 2011 | J. Biomed. Sci. | pmid:21645412 |
Lee YS et al. | Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G(2) /M phase arrest. | 2011 | Cell Prolif. | pmid:21645154 |
Donati C et al. | Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6. | 2011 | PLoS ONE | pmid:21629665 |
Beech DJ | Integration of transient receptor potential canonical channels with lipids. | 2012 | Acta Physiol (Oxf) | pmid:21624095 |
Lim KG et al. | (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. | 2011 | Cell. Signal. | pmid:21620961 |
Christoffersen C et al. | Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21606363 |
Doyle T et al. | Sphingosine-1-phosphate acting via the S1Pâ‚ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia. | 2011 | Neurosci. Lett. | pmid:21605625 |
Chiba Y et al. | Sphingosine-1-phosphate augments agonist-mediated contraction in the bronchial smooth muscles of mice. | 2011 | Pharmacol Rep | pmid:21602610 |
Bréart B et al. | Lipid phosphate phosphatase 3 enables efficient thymic egress. | 2011 | J. Exp. Med. | pmid:21576386 |
Li MH et al. | Sphingolipid modulation of angiogenic factor expression in neuroblastoma. | 2011 | Cancer Prev Res (Phila) | pmid:21576349 |
Wu LY et al. | Metabolite modulation of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiol. | 2011 | Biochim. Biophys. Acta | pmid:21571040 |
Fenger M et al. | Genetics of the ceramide/sphingosine-1-phosphate rheostat in blood pressure regulation and hypertension. | 2011 | BMC Genet. | pmid:21569466 |
Soleimani R et al. | Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. | 2011 | PLoS ONE | pmid:21559342 |
Finney CA et al. | S1P is associated with protection in human and experimental cerebral malaria. | 2011 | Mol. Med. | pmid:21556483 |
Oo ML et al. | Engagement of S1Pâ‚-degradative mechanisms leads to vascular leak in mice. | 2011 | J. Clin. Invest. | pmid:21555855 |
Gu Y et al. | Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway. | 2011 | J. Cell Biol. | pmid:21555463 |